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male guinea pigs

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Natural
Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0487
    Ethisterone

    Pregneninolone; 17α-Ethynyltestosterone

    		 Estrogen Receptor/ERR Metabolic Disease
    Ethisterone (Pregneninolone; 17α-Ethynyltestosterone) is a synthetic steroidal estrogen, is an orally active steroidal contraceptive agent. Ethisterone has almost no effect on the phagocytic activity of the reticuloendothelial system in male guinea pigs, while in utero exposure can induce abnormalities in the urogenital system of offspring .
    Ethisterone
  • HY-B1849
    Hexazinone

    		Environmental Pollutants Herbicide Others
    Hexazinone is a triazinone herbicide with high mobility and persistence in soil. Hexazinone is mainly degraded by soil microorganisms, and its degradation and mineralization processes are significantly affected by soil texture (faster in clay loam) and application method (mixed application can improve its bioavailability and mineralization rate). Hexazinone exhibits mild to moderate acute oral toxicity and has significant eye irritation .
    Hexazinone
  • HY-118834
    Teleocidin A1

    Lyngbyatoxin A

    		 PKC Inflammation/Immunology Cancer
    Teleocidin A1 (Lyngbyatoxin A) is a PKC activator with a Ki value of 0.11 nM for binding to the PKCδ-C1B peptide. Teleocidin A1 exhibits anticancer activity against cervical cancer and leukemia. Teleocidin A1 can induce seaweed dermatitis, food poisoning and local skin toxicity. Teleocidin A1 can be used in studies related to cervical cancer, seaweed dermatitis and food poisoning .
    Teleocidin A1
  • HY-B0487R
    Ethisterone (Standard)

    Pregneninolone (Standard); 17α-Ethynyltestosterone (Standard)

    		 Reference Standards Estrogen Receptor/ERR Metabolic Disease
    Ethisterone (Pregneninolone; 17α-Ethynyltestosterone) (Standard) is the analytical standard of Ethisterone (HY-B0487). This product is intended for research and analytical applications. Ethisterone is a synthetic steroidal estrogen, is an orally active steroidal contraceptive agent. Ethisterone has almost no effect on the phagocytic activity of the reticuloendothelial system in male guinea pigs, while in utero exposure can induce abnormalities in the urogenital system of offspring .
    Ethisterone (Standard)
  • HY-W766130
    Ethisterone-13C2

    Pregneninolone-13C2; 17α-Ethynyltestosterone-13C2

    		 Isotope-Labeled Compounds Estrogen Receptor/ERR Metabolic Disease
    Ethisterone- 13C2 (Pregneninolone- 13C2) is the 13C-labeled Ethisterone (HY-B0487). Ethisterone (Pregneninolone; 17α-Ethynyltestosterone) is a synthetic steroidal estrogen, is an orally active steroidal contraceptive agent. Ethisterone has almost no effect on the phagocytic activity of the reticuloendothelial system in male guinea pigs, while in utero exposure can induce abnormalities in the urogenital system of offspring.
    Ethisterone-13C2
  • HY-180411
    SM-15178

    		Leukotriene Receptor Inflammation/Immunology
    SM-15178 is a potent, orally active and selective leukotriene B4 (LTB4) receptor antagonist with an IC50 of 0.30 μM. SM-15178 attenuates LTB4 (HY-107608)-induced neutrophil accumulation in mouse skin and bronchoconstriction in guinea pigs. SM-15178 emonstrates significant anti-inflammatory efficacy across multiple animal models of inflammation. SM-15178 can be used for the research of chronic inflammatory diseases such as inflammatory bowel disease, psoriasis, and asthma .
    SM-15178
  • HY-181770
    PDE4B-IN-7

    		Phosphodiesterase (PDE) Bacterial Infection Inflammation/Immunology
    PDE4B-IN-7 is a PDE-4B inhibitor with an IC50 of 160 nM. PDE4B-IN-7 can form a firm and stable binding with the active site of PDE-4B. PDE4B-IN-7 inhibits acetylcholine-induced bronchospasm in guinea pigs. PDE4B-IN-7 exerts activity against susceptible Gram-positive and Gram-negative bacterial strains. PDE4B-IN-7 can be used for the researches of asthma and bacterial agent .
    PDE4B-IN-7
  • HY-18060B
    Bradanicline tosylate

    TC-5619 tosylate

    		 nAChR Inflammation/Immunology
    Bradanicline (TC-5619) tosylate is an orally active agonist of α7 nAChR with moderate blood-brain barrier penetration. Bradanicline tosylate exhibits high affinity and subtype selectivity for human α7 nAChR. Bradanicline tosylate possesses antitussive activity that depends on sustained receptor binding and activation. Bradanicline tosylate requires systemic administration to dose-dependently inhibit cough induced by citric acid, bradykinin and inhaled nicotine. Bradanicline tosylate is well tolerated in preclinical studies and is widely used in research related to chronic refractory cough .
    Bradanicline tosylate

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