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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
migraine pain
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "migraine pain" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-N0745
CAS No.: 94596-28-8
Category:
Natural Products Dicerothamnus rhinocerotis Plants Umbelliferae Disease Research Fields Inflammation/Immunology
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1
1 Cited Publications
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JNJ-17203212 is a selective, potent and competitive TRPV1 antagonist. JNJ-17203212 is developed for researching pain management, such as migraine .
Cat. No.: HY-172182
CAS No.: 2230296-66-7
Synonyms: VU6011887
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ONO-2920632 is an orally active and central nervous system (CNS)-penetrant TREK activator, with EC50 values of 0.3 µM and 2.8 μM for TREK-1 and TREK-2, respectively. ONO-2920632 exhibits selectivity for other K2P channels (>91-fold selective versus TASK1, TASK2, TASK3, TRAAK, and TWIK2; 31-fold selective versus TRESK). ONO-2920632 possesses analgesic effects and can be used in research on pain, migraine, and neurological disorders.
Cat. No.: HY-19876
CAS No.: 935481-06-4
Synonyms: Debio-0827
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PL37 (Debio-0827) is an orally active, blood-brain barrier permeable dual enkephalinase inhibitor. PL37 inhibits aminopeptidase N, neprilysin, and metalloproteases, thereby blocking the degradation of endogenous enkephalins, elevating enkephalin levels, and activating peripheral μ- and δ-opioid receptors. PL37 induces mitochondrial dysfunction, mitophagy, and apoptosis, inhibits endothelial cell proliferation, migration, invasion, and tube formation, and suppresses hemangioma tumor growth and angiogenesis. PL37 can be used in research related to peripheral neuropathic pain, osteosarcoma-induced hyperalgesia, painful diabetic neuropathy, migraine, bone cancer pain, neuroinflammatory pain, and infantile hemangioma .
Cat. No.: HY-124277
CAS No.: 1644134-60-0
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ADM 12 is a highly selective transient receptor potential ankyrin 1 (TRPA1) channel antagonist. ADM 12 blocks nitroglycerin (NTG)-induced trigeminal hyperalgesia in animal models, reducing expression of pain-related genes (c-Fos, TRPA1) and neuropeptides (CGRP, SP). ADM_12 is promising for research of migraine and neuropathic pain .
Cat. No.: HY-176297
CAS No.: 620113-98-6
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Tezampanel etibutil is an orally active AMPA/GluR antagonist. Tezampanel etibutil can be used in the research of pain, migraine, and neurological disorders .
Cat. No.: HY-119121
CAS No.: 951135-00-5
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JNJ-38893777 is an orally active and highly selective transient receptor potential vanilloid type 1 (TRPV1) channel antagonist. JNJ-38893777 inhibits neuronal hyperactivation and reduces inflammatory hyperalgesia. JNJ-38893777 is promising for research of migraine headaches, neuropathic and inflammatory pain .
Cat. No.: HY-137090
CAS No.: 139191-80-3
Synonyms: BP 2.94
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BP 2-94 (BP 2.94) is an orally active and highly selective prodrug targeting the histamine H3 receptor. BP 2-94 exerts anti-inflammatory, analgesic and antinociceptive effects by inhibiting histamine release and modulating neurogenic inflammation. BP 2-94 is promising for research of asthma, migraines, and inflammatory pain-related disorders .
Cat. No.: HY-W005637
CAS No.: 536-25-4
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Orthocaine is a local analgesic and local anesthetic. Orthocaine can be used for research on superficial painful injuries and various types of pain .
Cat. No.: HY-172583
CAS No.: 2757093-41-5
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Neuroprotective agent 9 (compound 7) is a neuroprotective agent. Neuroprotective agent 9 is promising for research of neuron injury such as cerebral apoplexy, cerebral injury, and neuropathic pain .
Cat. No.: HY-P2428
CAS No.: 95034-26-7
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Cat. No.: HY-178698
CAS No.: 342882-77-3
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O-1812 is a selective CB1 ligand. O-1812 is also a very weak AMT inhibitor. O-1812 can be used in the research of chronic pain, migraines, and inflammation .
Cat. No.: HY-184963
CAS No.: 913087-59-9
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Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
Anticonvulsant agent 12 is a naphthalene-containing azole compound with anticonvulsant activity. Anticonvulsant agent 12 can be used in the research of central nervous system diseases including anxiety, depression, convulsion, epilepsy, migraine, bipolar disorder, substance abuse, smoking, ADHD, obesity, sleep disorders, stroke, neuropathic pain, cognitive impairment, neurodegenerative diseases and muscle spasms .
Cat. No.: HY-184055
CAS No.: 2643356-08-3
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NMDA receptor antagonist-12 (Example 17) is an antagonist of NMDA receptors containing the NR2B subunit. NMDA receptor antagonist-12 exerts antagonistic effects on NMDA receptors containing the NR2B subunit and blocks the intracellular Ca 2+ influx mediated by these receptors. NMDA receptor antagonist-12 can be used in research related to diseases such as depression, bipolar disorder, migraine, and pain .
Cat. No.: HY-182466
CAS No.: 2776175-74-5
Synonyms: BHV-2100
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Ponometrep (BHV-2100) is a transient receptor potential melastatin 3 (TRPM3) antagonist with IC50 values of 1-10 nM. Ponometrep shows analgesic activity and can be used for the research of neurological diseases .
Cat. No.: HY-103127
CAS No.: 1539266-32-4
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25CN-NBOH hydrochloride exhibits agonist activity at the 5-HT2a receptor, shows 90- to 100-fold selectivity over the 5-HT2c receptor, and possesses blood-brain barrier permeability . 25CN-NBOH hydrochloride acts as an interoceptive agent with partial agonist-like properties . 25CN-NBOH hydrochloride serves as a pharmacological tool for 5-HT2A receptor research, and its tritiated form functions as a selective agonist radioligand . 25CN-NBOH hydrochloride can be used to investigate diseases characterized by cognitive rigidity, schizophrenia, obsessive-compulsive disorder, depression, pain, inflammation, migraine, and cluster headache .
Cat. No.: HY-179684
CAS No.: 2921670-99-5
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PCC0105005 is a dual-target CGRP Receptor antagonist (IC50 = 1.01 nM) and a partial agonist of 5-HT1F Receptor (EC50 = 77.91 nM). PCC0105005 shows significant efficacy in the rat model of migraine. PCC0105005 significantly reduces the expression of CGRP and c-Fos proteins, and inhibits the phosphorylation levels of ERK and CREB. PCC0105005 can be used for research on migraine .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
