951135-00-5
Chemical Structure
JNJ-38893777
- CAS. Nr.: 951135-00-5
- Formula:C26H26F6N6
- Molecular Weight:536.52
IUPAC Name: 2-(piperidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepin-4-amine
InChIKey: MRHHSXHMRZMNIM-UHFFFAOYSA-N
SMILES: FC(C1=CC=CN=C1N2CCC3=NC(N4CCCCC4)=NC(NC5=CC=C(C(F)(F)F)C=C5)=C3CC2)(F)F
Biological Activity: JNJ-38893777 is an orally active and highly selective transient receptor potential vanilloid type 1 (TRPV1) channel antagonist. JNJ-38893777 inhibits neuronal hyperactivation and reduces inflammatory hyperalgesia. JNJ-38893777 is promising for research of migraine headaches, neuropathic and inflammatory pain[1].
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JNJ-38893777 | JNJ-38893777 is an orally active and highly selective transient receptor potential vanilloid type 1 (TRPV1) channel antagonist. JNJ-38893777 inhibits neuronal hyperactivation and reduces inflammatory hyperalgesia. JNJ-38893777 is promising for research of migraine headaches, neuropathic and inflammatory pain. | |||||||||||||||||||||
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References
- [1]. Manitpisitkul P, et al. Safety, Tolerability and Pharmacokinetic and Pharmacodynamic Learnings from a Double-Blind, Randomized, Placebo-Controlled, Sequential Group First-in-Human Study of the TRPV1 Antagonist, JNJ-38893777, in Healthy Men. Clin Drug Investig. 2015 Jun;35(6):353-63. [Content Brief]
