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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
mutp53
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "mutp53" in MCE Product Catalog:
SLMP53-2 is a mutant p53 reactivator. SLMP53-2 restores wild-type-like conformation and DNA-binding ability of mutp53-Y220C by enhancing its interaction with the Hsp70, leading to the reestablishment of p53 transcriptional activity. SLMP53-2 can induce cell cycle arrest, apoptosis and endoplasmic reticulum (ER) stress. SLMP53-2 exhibits antitumor activity .
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Anticancer agent 168 (compound d16) is a inhibitor of DNA2. Anticancer agent 168 induces apoptosis and cell-cycle arrest mainly at S-phase, and exhibits anticancer activities and overcomes chemotherapy resistance in mutp53-bearing cancers .
Cat. No.: HY-189209
CAS No.: 850824-74-7
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TopBP1-IN-3 is an inhibitor of the TopBP1 BRCT7/8 domain. TopBP1-IN-3 disrupts the BRCT7/8-dependent interactions between TopBP1 and E2F1, mutp53, MIZ1, PLK1, and CIP2A, without affecting its protein binding mediated by other BRCT domains. TopBP1-IN-3 can be used for the research of ovarian cancer and breast cancer .
Cat. No.: HY-W320366
CAS No.: 896074-75-2
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TopBP1-IN-5 is a TopBP1-BRCT7/8 inhibitor (IC50=2.47-3.8 nM). TopBP1-IN-5 selectively disrupts the interaction of TopBP1-BRCT7/8 with E2F1, mutp53, MIZ1, PLK1, CIP2A, and Top2A, without affecting BRCT1/2- and BRCT5-mediated interactions. TopBP1-IN-5 activates caspase-3/7 and caspase-8 to induce prometaphase arrest, mitotic catastrophe, and apoptosis, while inhibiting the MYC transcriptional program and enhancing the binding of MIZ1 to the p21Cip1 promoter. TopBP1-IN-5 exhibits broad-spectrum anticancer activity in triple-negative breast cancer, ovarian cancer, lung cancer, and acute myeloid leukemia models, and can be used for research on related cancers .
Cat. No.: HY-189208
CAS No.: 902332-77-8
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TopBP1-IN-2 is an inhibitor of the TopBP1 BRCT7/8 domain, with a pS1159 phosphopeptide competition IC50 of 6 nM. TopBP1-IN-2 also blocks the direct interaction between TopBP1-BRCT7/8 and the DNA-binding domain of mutp53R273H, exhibiting an IC50 of 25 nM. TopBP1-IN-2 selectively induces cancer cell apoptosis and inhibits their clonogenic formation, with no significant effects on normal cells. TopBP1-IN-2 is applicable in research related to breast cancer and ovarian cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
