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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
neurite differentiation
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "neurite differentiation" in MCE Product Catalog:
2
2 Cited Publications
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Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite Disease Research Fields Inflammation/Immunology
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PD 174265 is a highly selective, reversible EGFR/ErbB2 tyrosine kinase inhibitor (IC50=0.45 nM) and cell differentiation inducer. By blocking receptor autophosphorylation and the downstream ERK signaling pathway (with an IC50 of 0.45 μM for full-length ERK), PD 174265 effectively inhibits tumor growth and exhibits antitumor activity without obvious toxicity in in vivo models. PD 174265 drives oligodendrocyte precursor cells to switch from a proliferative state to a differentiated state, significantly upregulates the expression of myelin proteins such as CNP, PLP and MBP, and induces neurite branching. PD 174265 shows no inhibitory effect on other kinases including insulin, PDGF and basic FGF receptors, and serves as a crucial tool molecule for investigating the treatment of human epidermoid carcinoma and the mechanism of myelin repair in multiple sclerosis .
Cat. No.: HY-N8303
CAS No.: 21187-73-5
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Flavonoids Flavones Rutaceae Plants Citrus reticulata Blanco
Cat. No.: HY-E70043
CAS No.: 2170331-76-5
Synonyms: Sialidase isoenzyme S; AuSialidase S
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Ganglioside sialidase (AuSialidase S) is an endogenous metabolite. Ganglioside sialidases have been implicated in neuronal differentiation processes, including neurite outgrowth .
Cat. No.: HY-113357R
CAS No.: 588-30-7
Cat. No.: HY-165616
CAS No.: 309711-72-6
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NS 1231 is a neurotrophic-like compound with neuroprotective effect. NS 1231 can rescue nerve growth factor (NGF)-differentiated PC12 cells from death induced by withdrawal of trophic factors. NS 1231 can stimulate NGF-induced neurite outgrowth of undifferentiated PC12 cells. NS 1231 can be used for the research of neurological disease, such as stroke .
Cat. No.: HY-11055
CAS No.: 393856-87-6
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KP 544 is a potent neurotrophic protein enhancer that amplifies nerve growth factor (NGF)-induced neurite outgrowth of PC12 cells and SH-SY5Y neuroblastoma cells. KP544 also enhances choline acetyltransferase activity. KP 544 selectively interact in the differentiation pathway downstream of MAPK in a manner that amplifies nerve growth factor and cyclic AMP effects and is also neuroprotective .
Cat. No.: HY-113253AR
CAS No.: 34450-15-2
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Cat. No.: HY-D3423
Synonyms: FM 2-10FX
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AM2-10 (FM 2-10FX) is a Fluorescent dye used for liquid-phase endocytosis imaging. AM2-10 stains cell membranes to observe neurite length during NGF-induced cell differentiation .
Cat. No.: HY-183059
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TNIK-IN-11 is a TNIK inhibitor with a human TNIK pIC50 of 7.80. TNIK-IN-11 inhibits TNIK kinase activity and promotes neurite outgrowth. TNIK-IN-11 activates AKT signaling via increased phosphorylated AKT levels, and induces gene expression changes including upregulation of neuronal differentiation and morphological remodeling genes. TNIK-IN-11 can be used for the research of dup15q syndrome .
Cat. No.: HY-P11777
CAS No.: 170655-66-0
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Cat. No.: HY-183405
CAS No.: 143984-56-9
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CD2019 is a selective retinoic acid receptor β (RARβ) agonist, with a Kd value of 26 nM for RARβ and an AC50 value of 3.8 nM for human RARβ. CD2019 regulates downstream biological effects via the PI3K signaling pathway. CD2019 suppresses squamous metaplasia, inhibits squamous differentiation markers, maintains pseudostratified epithelial structure, induces neurite and axon growth, and promotes functional recovery; it exhibits cytotoxicity at higher concentrations and reduces endogenous retinol levels. CD2019 can be used in studies related to squamous metaplasia, spinal cord injury and embryonic malformations .
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Sigma-1 receptor modulator-1 is a sigma-1 receptor modulator and acetylcholinesterase (AChE) inhibitor. Sigma-1 receptor modulator-1 binds to sigma-1 receptors in guinea pigs with a Ki of 1.8 nM. Sigma-1 receptor modulator-1 modulates chaperone proteins, restores calcium homeostasis, and controls ROS production. Sigma-1 receptor modulator-1 inhibits AChE activity and scavenges free radicals. Sigma-1 receptor modulator-1 can be used for research on neurodegenerative diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
