3 Results for "

osteosarcoma Saos-2 cells

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "osteosarcoma Saos-2 cells" in MCE Product Catalog:

Cat. No.: HY-N2896
CAS No.: 465-00-9
Arjunolic acid is an orally active, multifunctional bioactive compound. Arjunolic acid exhibits free radical scavenging activity, as well as fungal and bacterial activities. Arjunolic acid induces apoptosis (Apoptosis) in various cancer cells. Arjunolic acid protects hepatocytes against induced oxidative stress and apoptosis by reducing reactive oxygen species and inhibiting NF-κB activation. Arjunolic acid regulates pancreatic dysfunction in type 2 diabetic rats by blocking the activation of the TLR-4/MyD88 and canonical Wnt pathways. Arjunolic acid inhibits neuroinflammation and ameliorates depressive behaviors via the SIRT1/AMPK/Notch1 signaling pathway in microglia. Arjunolic acid improves Crohn's disease-like colitis by restoring gut microbiota composition and inhibiting TLR4 signaling. Arjunolic acid suppresses osteosarcoma progression by inhibiting Wnt3a-mediated M2 polarization of macrophages. Arjunolic acid ameliorates diabetic retinopathy via the autophagy pathway regulated by AMPK/mTOR/HO-1. Arjunolic acid is applicable to research related to type 2 diabetes, organ toxicity, depression, Crohn's disease, osteosarcoma, diabetic retinopathy, and testicular dysfunction .
loading...
    loading...
Cat. No.: HY-174240
Target:  

Drug Derivative

Research Areas:  

Cancer

Anticancer agent 274 (Compound 1) is a Sorafenib (HY-10201) analog. Anticancer agent 274 can inhibit the growth of tumor cells, with IC50 values of 0.034 μM and 0.042 μM against SaOS-2 and MNNG-HOS cells, respectively. Anticancer agent 274 has relatively low toxicity to normal cells and can be used in the research of tumors such as osteosarcoma .
loading...
    loading...
Cat. No.: HY-182550
CAS No.: 2763081-61-2
Research Areas:  

Cancer

Indoluidin D is a selective dihydroorotate dehydrogenase (DHODH) inhibitor with a human DHODH IC50 of 210 nM. Indoluidin D selectively inhibits human DHODH activity, with induced effects rescuable by orotic acid. Indoluidin D promotes myeloid differentiation and inhibits cancer cell proliferation. Indoluidin D can be used for the research of acute promyelocytic leukemia .
loading...
    loading...