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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
pleckstrin homology
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "pleckstrin homology" in MCE Product Catalog:
2
2 Cited Publications
PHT-247 is an inhibitor of the pleckstrin homology (PH) domain of Akt, and it is also an inhibitor of PDPK1 with Kis of 2.7 µM and 5.2 µM and for Akt and PDPK1, respectively.
1
1 Cited Publications
PHT-7.3 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain (Kd=4.7 μM). PHT-7.3 inhibits mut-KRas, but not wild-type KRas cancer cell and tumor growth and signaling. PHT-7.3 has antitumor activity .
FPA-124, a cell-permeable copper complex, is a selective Akt inhibitor with an IC50 of 0.1 μM. FPA-124 interacts with both the pleckstrin homology (PH) and the kinase domains of Akt. FPA-124 induces apoptosis .
Cat. No.: HY-19820
CAS No.: 739301-85-0
Target:
Research Areas:
NSC45586 is an inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP). NSC45586 targets the PP2C phosphatase domain in PHLPP1 and PHLPP2. NSC45586 can activate AKT in neurons .
Category:
Target:
Cat. No.: HY-W719359
Cat. No.: HY-115739
CAS No.: 1009376-10-6
Target:
Research Areas:
RTIL 13 is a potent inhibitor of dynamin GTPase, with an IC50 of 2.3 μM for dynamin I GTPase. RTIL 13 also targets pleckstrin homology lipid binding domain. RTIL 13 can inhibit receptor-mediated and synaptic vesicle endocytosis, with IC50s of 9.3 μM and 7.1 μM, respectively .
Cat. No.: HY-180884
BTK-IN-46 (compound 24) is a reversible covalent BTK inhibitor. BTK-IN-46 covalently labels a lysine in the inositol phosphate (PIP3) binding site, thereby blocking Pleckstrin homology (PH) domain-mediated membrane recruitment and activation of BTK .
Cat. No.: HY-P811949
Synonyms: PLEKHQ1, PP9099, PLEKHO2, pleckstrin homology domain-containing family O member 2, PH domain-containing family O member 2, pleckstrin homology domain-containing family Q member 1, PH domain-containing family Q member 1
Cat. No.: HY-P811949A
Synonyms: PLEKHQ1, PP9099, PLEKHO2, pleckstrin homology domain-containing family O member 2, PH domain-containing family O member 2, pleckstrin homology domain-containing family Q member 1, PH domain-containing family Q member 1
Cat. No.: HY-P703262
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CYTH2; pleckstrin homology, Sec7 And Coiled/Coil Domains 2 (Cytohesin-2); Prev. PSCD2; ARF Nucleotide-Binding Site Opener; Prev. PSCD2L; ARF Exchange Factor; Cytohesin-2; pleckstrin homology, Sec7 And Coiled-Coil Domains 2 (Cytohesin-2), Isoform CRA_c; AR
Species:
Human
Source:
E. coli
Cat. No.: HY-P705685
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: FERMT2; Kindlin-2; Prev. PLEKHC1; pleckstrin homology Domain Containing, Family C Member 1; KIND2; pleckstrin homology Domain-Containing Family C Member 1; UNC112B; Fermitin Family Homolog 2 (Drosophila); Mig-2; Mitogen Inducible Gene 2 Protein; Pleckstri
Species:
Human
Source:
E. coli
Cat. No.: HY-P812010
Synonyms: PLEKHF2; pleckstrin homology And FYVE Domain Containing 2; ZFYVE18; PHAFIN2; Endoplasmic Reticulum-Associated Apoptosis-Involved Protein Containing PH And FYVE Domains; pleckstrin homology Domain Containing, Family F (With FYVE Domain) Member 2; pleckstrin homology Domain-Containing Family F Member 2; Zinc Finger FYVE Domain-Containing Protein 18; PH And FYVE Domain-Containing Protein 2; PH Domain-Containing Family F Member 2; FLJ13187; EAPF; Phafin-2; Phafin2
Cat. No.: HY-P812010A
Synonyms: PLEKHF2; pleckstrin homology And FYVE Domain Containing 2; ZFYVE18; PHAFIN2; Endoplasmic Reticulum-Associated Apoptosis-Involved Protein Containing PH And FYVE Domains; pleckstrin homology Domain Containing, Family F (With FYVE Domain) Member 2; pleckstrin homology Domain-Containing Family F Member 2; Zinc Finger FYVE Domain-Containing Protein 18; PH And FYVE Domain-Containing Protein 2; PH Domain-Containing Family F Member 2; FLJ13187; EAPF; Phafin-2; Phafin2
Cat. No.: HY-P71202
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PHLDA2; Imprinted In Placenta And Liver Protein; Prev. TSSC3; P17-BWR1C; BWR1C; Tumor Suppressing Subchromosomal Transferable Fragment CDNA 3; HLDA2; pleckstrin homology-Like Domain, Family A, Member 2; IPL; Tumor-Suppressing STF CDNA 3 Protein; Tumor-Sup
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
