902779-59-3
902779-59-3
Chemical Structure
FPA-124
- CAS No.: 902779-59-3
- Formula:C11H9Cl2CuN3O2S
- Molecular Weight:381.73
SMILES: O=C1C2=CC=CC=C2OC=C1/C=[N]3[Cu]([Cl-])([S]=C(N)N\3)[Cl-]
Biological Activity: FPA-124, a cell-permeable copper complex, is a selective Akt inhibitor with an IC50 of 0.1 μM. FPA-124 interacts with both the pleckstrin homology (PH) and the kinase domains of Akt. FPA-124 induces apoptosis[1][2].
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FPA-124 | 95.0% | FPA-124, a cell-permeable copper complex, is a selective Akt inhibitor with an IC50 of 0.1 μM. FPA-124 interacts with both the pleckstrin homology (PH) and the kinase domains of Akt. FPA-124 induces apoptosis. | ||||||||||||||||||||
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References
- [1]. Barve V, et al. Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells. J Med Chem. 2006 Jun 29;49(13):3800-8. [Content Brief]
- [2]. Biscetti F, et al. Pioglitazone enhances collateral blood flow in ischemic hindlimb of diabetic mice through an Akt-dependent VEGF-mediated mechanism, regardless of PPARgamma stimulation. Cardiovasc Diabetol. 2009 Sep 8;8:49. [Content Brief]
Keywords
