NSC45586

Cat. No.: HY-19820: FAQs
Data Sheet Handling Instructions

Molarity Calculator

NSC45586 is an inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP). NSC45586 targets the PP2C phosphatase domain in PHLPP1 and PHLPP2. NSC45586 can activate AKT in neurons.

For research use only. We do not sell to patients.

NSC45586 Chemical Structure

CAS No. : 739301-85-0

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100 mg		Get quote
250 mg		Get quote
Other size		Get quote

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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of NSC45586:

NSC45586 sodium

Other Forms of NSC45586:

NSC45586 sodium In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

PHLPP1/2, Akt^[1]

Molecular Weight

390.40

Formula

C₂₀H₁₈N₆O₃

CAS No.

739301-85-0

SMILES

O=C(O)C1=CC(/N=N/C2=CC=C(/N=N/C3=CC(C)=C(N)C=C3N)C=C2)=CC=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 20.83 mg/mL (53.36 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5615 mL	12.8074 mL	25.6148 mL
5 mM	0.5123 mL	2.5615 mL	5.1230 mL
10 mM	0.2561 mL	1.2807 mL	2.5615 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jackson TC, et, al. Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytes. J Pharmacol Exp Ther. 2013 Nov;347(2):516-28. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5615 mL	12.8074 mL	25.6148 mL	64.0369 mL
	5 mM	0.5123 mL	2.5615 mL	5.1230 mL	12.8074 mL
	10 mM	0.2561 mL	1.2807 mL	2.5615 mL	6.4037 mL
	15 mM	0.1708 mL	0.8538 mL	1.7077 mL	4.2691 mL
	20 mM	0.1281 mL	0.6404 mL	1.2807 mL	3.2018 mL
	25 mM	0.1025 mL	0.5123 mL	1.0246 mL	2.5615 mL
	30 mM	0.0854 mL	0.4269 mL	0.8538 mL	2.1346 mL
	40 mM	0.0640 mL	0.3202 mL	0.6404 mL	1.6009 mL
	50 mM	0.0512 mL	0.2561 mL	0.5123 mL	1.2807 mL

NSC45586 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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