1614225-93-2
1614225-93-2
Chemical Structure
PHT-7.3
- CAS No.: 1614225-93-2
- Formula:C24H23N3O3S
- Molecular Weight:433.52
IUPAC Name: 4-((1,3-dioxan-2-yl)methyl)-2-((4-(p-tolyl)thiazol-2-yl)methyl)phthalazin-1(2H)-one
InChIKey: AFPMVLVIYVAFSP-UHFFFAOYSA-N
SMILES: O=C1C2=C(C=CC=C2)C(CC3OCCCO3)=NN1CC4=NC(C5=CC=C(C)C=C5)=CS4
Biological Activity: PHT-7.3 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain (Kd=4.7 μM). PHT-7.3 inhibits mut-KRas, but not wild-type KRas cancer cell and tumor growth and signaling. PHT-7.3 has antitumor activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PHT-7.3 | 99.29% | PHT-7.3 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain (Kd=4.7 μM). PHT-7.3 inhibits mut-KRas, but not wild-type KRas cancer cell and tumor growth and signaling. PHT-7.3 has antitumor activity. | ||||||||||||||||||||
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Structural Analogs
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Similarity Score 0.54
HY-19687Zopolrestat -
Similarity Score 0.49
HY-106697Ponalrestat -
Similarity Score 0.47
HY-163124HBV-IN-43 -
Similarity Score 0.46
HY-B0462B(S)-Azelastine hydrochloride -
Similarity Score 0.46
HY-B0462C(R)-Azelastine hydrochloride -
Similarity Score 0.46
HY-B0462RAzelastine hydrochloride (Standard) -
Similarity Score 0.46
HY-129586Govorestat -
Similarity Score 0.46
HY-147705PPARγ phosphorylation inhibitor 1 -
Similarity Score 0.46
HY-B0462D(S)-Azelastine -
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