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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
polynucleotide
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "polynucleotide" in MCE Product Catalog:
14
14 Cited Publications
Cat. No.: HY-D0178
CAS No.: 25952-53-8
Target:
Research Areas:
BCH001, a quinoline derivative, is a specific PAPD5 inhibitor. BCH001 restores telomerase activity and telomere length in dyskeratosis congenita (DC) induced pluripotent stem cells. BCH001 shows no inhibition of poly(A)-specific ribonuclease (PARN) or several other canonical and non-canonical polynucleotide polymerases. BCH001 is used to regulate aging .
Cat. No.: HY-131920A
CAS No.: 28086-43-3
Synonyms: Polyuridylic acid potassium
Target:
Research Areas:
A12B4C3 is a potent human polynucleotide kinase/phosphatase (hPNKP) inhibitor with an IC50 value of 0.06 μM. A12B4C3 has antiproliferative activity against cancer cells. A12B4C3 can also enhance the radiosensitivity of certain cancer cells .
Cat. No.: HY-W250124
CAS No.: 63231-63-0
Synonyms: RNA (yeast)
Cat. No.: HY-W010854
CAS No.: 72003-83-9
Synonyms: dADP disodium
Cat. No.: HY-W008550
CAS No.: 1123-54-2
Target:
Research Areas:
8-Azaadenine is an inhibitor of Xanthine Oxidase with an IC50 of 0.54 μM and a Ki of 0.66 μM. 8-Azaadenine can be produced via the metabolism of 8-Azaadenosine (HY-115686) and incorporated into polynucleotide chains together with 8-Azaguanine (HY-B1468) to affect purine metabolism. 8-Azaadenine can be used in the study of cancer .
Cat. No.: HY-P2844
CAS No.: 37211-65-7
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Research Areas:
Polynucleotide Kinase is a DNA repair enzyme. Polynucleotide Kinase possesses both a 5’-kinase activity that catalyzes the transfer of phosphate from ATP to a 5’-hydroxyl (OH) terminus and also a 3’-phosphatase activity that converts 3’-phosphate termini to 3’-OH termini .
Cat. No.: HY-W541025
CAS No.: 9007-49-2
Synonyms: 304O13
Tri-N-tridecyl 3-(ethyl(methyl)amino)propanoate is a biodegradable lipid prepared by the conjugate addition of alkylamines to acrylates. Tri-N-tridecyl 3-(ethyl(methyl)amino)propanoate can be used in various drug delivery systems to deliver polynucleotides, siRNA for example .
RCB-02-4-8 is an ionizable cationic lipid that is used to form lipid nanoparticles (LNPs) to deliver mRNA. RCB-02-4-8 can improve the efficiency of lung transfection in mice .
Cat. No.: HY-148363
CAS No.: 2714482-26-3
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Heptadecan-9-yl 8-((6-(decyloxy)-6-oxohexyl)(2-hydroxyethyl) amino) octanoate is an ionizable lipid that can be used in liposome delivery systems for the delivery of mRNA vaccines .
Cat. No.: HY-151510
CAS No.: 2412492-19-2
A2-Iso5-4DC19 is a lipidoid compound. A2-Iso5-4DC19 is an effective carrier for the delivery of an agent such as a polynucleotide to a cell .
Cat. No.: HY-146646
CAS No.: 41432-97-7
Target:
Bleomycin A2 is an antitumor Antibiotic and also an aspartate/asparagine-β-hydroxylase (AspH) inhibitor with an IC50 of 1.47 μM. Bleomycin A2 inhibits the polynucleotide ligase reaction in E. coli B infected by T4 phage. Bleomycin A2 promotes DNA degradation, induces DNA strand breaks and regulates DNA polymerase activity. Bleomycin A2 can be used in research related to leukemia, head and neck cancer, and Ehrlich carcinoma .
Cat. No.: HY-114582
CAS No.: 110124-49-7
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Lexitropsin is a netropsin derivative which is determined the binding and specificity properties in interaction with DNA and synthetic polynucleotides .
Cat. No.: HY-W552525
CAS No.: 402491-35-4
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Deoxyadenosine diphosphate sodium is a nucleoside diphosphate, in which the nucleoside is deoxyadenosine. Deoxyadenosine diphosphate sodium participates in DNA synthesis and repair. Deoxyadenosine diphosphate sodium acts as the inhibitor of polynucleotide phosphorylase, interfers with the polymerization of ADP and CDP .
Cat. No.: HY-187022
CAS No.: 3092408-38-0
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AMG 1541 is a degradable ionizable lipid. AMG 1541 mediates the delivery of polynucleotides including mRNA. AMG 1541 exerts potent neutralizing effects on pseudotyped lentiviruses carrying the B.1.617.2 spike protein. As a component of influenza vaccines, AMG 1541 enables robust immune activation and reduces vaccine dosage. AMG 1541 is applicable to research related to SARS-CoV-2 infection .
Cat. No.: HY-P71620
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PNKP; Homo Sapiens polynucleotide Kinase 3'-Phosphatase (PNKP); polynucleotide Kinase 3'-Phosphatase; EIEE10; Bifunctional polynucleotide Phosphatase/Kinase; CMT2B2; DNA 5'-Kinase/3'-Phosphatase; MCSZ; PNK; AOA4; polynucleotide Kinase-3'-Phosphatase
Species:
Human
Source:
E. coli
Cat. No.: HY-P86815
Synonyms: ATP/GTP binding protein antibody; Cleavage and polyadenylation factor I subunit 1 antibody; CLP 1 antibody; clp1 antibody; CLP1 cleavage and polyadenylation factor I subunit homolog antibody; CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae) antibody; CLP1, yeast, homolog of antibody; CLP1_HUMAN antibody; hClp1 antibody; Homolog of yeast CFIA subunit Clp1p antibody; ATP/GTP binding protein antibody; Cleavage and polyadenylation factor I subunit 1 antibody; CLP 1 antibody; clp1 antibody; CLP1 cleavage and polyadenylation factor I subunit homolog antibody; CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae) antibody; CLP1, yeast, homolog of antibody; CLP1_HUMAN antibody; hClp1 antibody; Homolog of yeast CFIA subunit Clp1p antibody; Polyadenylation factor Clp1 antibody; polynucleotide kinase Clp1 antibody; Polyribonucleotide 5' hydroxyl kinase Clp1 antibody; Polyribonucleotide 5''-hydroxyl-kinase Clp1 antibody; Pre mRNA cleavage complex II protein Clp1 antibody; Pre-mRNA cleavage complex II protein Clp1 antibody;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
