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Cat. No.: HY-187022

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AMG 1541

AMG 1541 is a degradable ionizable lipid. AMG 1541 mediates the delivery of polynucleotides including mRNA. AMG 1541 exerts potent neutralizing effects on pseudotyped lentiviruses carrying the B.1.617.2 spike protein. As a component of influenza vaccines, AMG 1541 enables robust immune activation and reduces vaccine dosage. AMG 1541 is applicable to research related to SARS-CoV-2 infection.

For research use only. We do not sell to patients.

CAS No.: 3092408-38-0
Formula: C₁₀₂H₁₈₆N₆O₁₈
Molecular Weight:1784.63

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

AMG 1541 Chemical Structure

CAS No.: 3092408-38-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Viral InfectionOthers

Viral Infection

AMG 1541 potently neutralizes B.1.617.2 spike protein pseudovirus in 293T-ACE2 cells^[1].

Others

AMG 1541 (40 ng/well) mediates luciferase reporter gene expression in C2C12 cells, producing a detectable luminescent signal at a dose of 40 ng/well^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Adaptive ImmunityOthersLipid Metabolism

Adaptive Immunity

AMG 1541 (0.01-1 µg; intramuscular injection; administered twice on day 0 and day 21) induces significant humoral and cell-mediated immune responses in mice, with hemagglutination inhibition titers increasing in a dose-dependent manner^[1].

Others

AMG 1541 (intravenous injection) effectively delivers mRNA to the liver of mice, achieving a total hepatic flux of approximately 1.1×10¹⁰ p/s^[1].
AMG 1541 (0.25-1 mg/kg; intravenous injection) effectively delivers hEPO mRNA in mice, inducing a dose-dependent increase in serum hEPO levels, with an average level of 1200-1300 IU/mL (upper limit of approximately 1500 IU/mL) at the 1 mg/kg dose^[1].

Lipid Metabolism

AMG 1541 (0.5-3 mg/kg; intravenous administration) mediates dose-dependent PCSK9 gene editing in mouse livers, achieves approximately 31% indels at the dose of 3 mg/kg, and reduces serum PCSK9 levels to approximately 5% of the baseline value^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice^[1]
Dosage:

0.01 µg; 0.1 µg; 1 µg
Administration:

i.m.; 2 doses on day 0 and day 21
Result:

Achieved a mean log[Endpoint Titer] of approximately 6.7 in male mice and approximately 7.1 in female mice.
Induced significantly higher log[Endpoint Titer] (mean ~6.8) compared to SM-102 (mean ~5.9).
Induced a mean of ~2000 SFU/5×10⁵ cells (range ~1000-2600) for MHC-I responses.
Induced a mean of ~500 SFU/5×10⁵ cells (range ~0-700) for MHC-II responses.
Induced log[HAI Titer] values of ~2.5 at 0.01 µg, ~2.2 at 0.1 µg, and ~3.2 at 1 µg.

Related Protocols :

Chemical Information

CAS No. 3092408-38-0
Molecular Weight 1784.63
Formula C₁₀₂H₁₈₆N₆O₁₈
SMILES

C(C(COC(CCC/C=C\CCCCCC)=O)O)N1CCN(CC(COC(CCC/C=C\CCCCCC)=O)O)CCN(CC(COC(CCC/C=C\CCCCCC)=O)O)CCN(CC(COC(CCC/C=C\CCCCCC)=O)O)CCN(CC(COC(CCC/C=C\CCCCCC)=O)O)CCN(CC(COC(CCC/C=C\CCCCCC)=O)O)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Daniel Griffith Anderson, et al. Biodegradable lipids and formulations for delivery of mrna. US20250205158A1.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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