AMG 1541
AMG 1541 is a degradable ionizable lipid. AMG 1541 mediates the delivery of polynucleotides including mRNA. AMG 1541 exerts potent neutralizing effects on pseudotyped lentiviruses carrying the B.1.617.2 spike protein. As a component of influenza vaccines, AMG 1541 enables robust immune activation and reduces vaccine dosage. AMG 1541 is applicable to research related to SARS-CoV-2 infection.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3092408-38-0
- 分子式: C102H186N6O18
- 分子量:1784.63
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
AMG 1541 potently neutralizes B.1.617.2 spike protein pseudovirus in 293T-ACE2 cells[1].
AMG 1541 (40 ng/well) mediates luciferase reporter gene expression in C2C12 cells, producing a detectable luminescent signal at a dose of 40 ng/well[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
AMG 1541 (intravenous injection) effectively delivers mRNA to the liver of mice, achieving a total hepatic flux of approximately 1.1×1010 p/s[1].
AMG 1541 (0.25-1 mg/kg; intravenous injection) effectively delivers hEPO mRNA in mice, inducing a dose-dependent increase in serum hEPO levels, with an average level of 1200-1300 IU/mL (upper limit of approximately 1500 IU/mL) at the 1 mg/kg dose[1].
AMG 1541 (0.5-3 mg/kg; intravenous administration) mediates dose-dependent PCSK9 gene editing in mouse livers, achieves approximately 31% indels at the dose of 3 mg/kg, and reduces serum PCSK9 levels to approximately 5% of the baseline value[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice[1]
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Dosage:0.01 µg; 0.1 µg; 1 µg
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Administration:i.m.; 2 doses on day 0 and day 21
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Result:Achieved a mean log[Endpoint Titer] of approximately 6.7 in male mice and approximately 7.1 in female mice.
Induced significantly higher log[Endpoint Titer] (mean ~6.8) compared to SM-102 (mean ~5.9).
Induced a mean of ~2000 SFU/5×105 cells (range ~1000-2600) for MHC-I responses.
Induced a mean of ~500 SFU/5×105 cells (range ~0-700) for MHC-II responses.
Induced log[HAI Titer] values of ~2.5 at 0.01 µg, ~2.2 at 0.1 µg, and ~3.2 at 1 µg.
化学情報
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CAS 番号 3092408-38-0
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分子量 1784.63
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分子式 C102H186N6O18
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SMILES
C(C(COC(CCC/C=C\CCCCCC)=O)O)N1CCN(CC(COC(CCC/C=C\CCCCCC)=O)O)CCN(CC(COC(CCC/C=C\CCCCCC)=O)O)CCN(CC(COC(CCC/C=C\CCCCCC)=O)O)CCN(CC(COC(CCC/C=C\CCCCCC)=O)O)CCN(CC(COC(CCC/C=C\CCCCCC)=O)O)CC1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AMG 1541 関連分類
HY-187022 関連分類
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