Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
renal hypertensive
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "renal hypertensive" in MCE Product Catalog:
8
Target:
Research Areas:
Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .
Cat. No.: HY-110183
CAS No.: 51833-76-2
Target:
Research Areas:
Cat. No.: HY-19732
CAS No.: 133085-33-3
Target:
Research Areas:
BIBS 39 is a non-peptide angiotensin II receptor antagonist with antihypertensive activity, with higher affinity for the AT1 receptor than for the AT2 receptor. BIBS 39 competitively blocks AT1-mediated vasoconstriction and pressor responses, and effectively inhibits the activity of the renin-angiotensin-aldosterone system. BIBS 39 reduces diastolic blood pressure and induces mild, transient reflex tachycardia, with no off-target functional activity on the norepinephrine, K +/Cl − or vasopressin pathways. BIBS 39 can be used in research related to hypertension and renal hypertension [1][2 ][3].
Target:
Research Areas:
Guancydine (Guancidine) is an orally active antihypertensive agent and vasodilator. Guancydine antagonizes the pressor effects of Angiotensin and Norepinephrine (HY-13715). Guancydine induces vasodilation in renal, mesenteric and cranial vascular beds, reduces peripheral resistance, increases cardiac output and lowers arterial blood pressure. Guancydine increases renal and forearm blood flow, reduces renal and forearm vascular resistance, alters cardiac systolic time, and reverses myocardial hypertrophy in hypertensive rats. Guancydine is applicable for research related to hypertension .
Cat. No.: HY-B0202A
CAS No.: 329055-23-4
Synonyms: SR-47436 hydrochloride; BMS-186295 hydrochloride
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .
Cat. No.: HY-19155A
CAS No.: 135015-84-8
Synonyms: ZD-8731
Target:
Research Areas:
ICI-D 8731 (compound 5g) is a angiotensin II receptor antagonist with the IC50 of 0.031 μM. ICI-D 8731 shows a rapid and sustained lowering of blood pressure in a renal hypertensive rat model .
Cat. No.: HY-121550
CAS No.: 139958-16-0
Research Areas:
ME3221 is an angiotensin AT1 receptor antagonist that effectively antagonizes the pressor response to angiotensin II in rats and marmosets without affecting the hypotensive response to bradykinin. It demonstrates potent antihypertensive effects in renal hypertensive rats and spontaneously hypertensive rats (SHR). ME3221's repeated administration in SHR results in sustained and stable hypotensive effects without affecting heart rate, indicating its potential for studying both renal and essential hypertension .
Cat. No.: HY-123226
CAS No.: 190602-72-3
Target:
Research Areas:
TA-606 is a potent and orally active angiotensin II-receptor antagonist. TA-606 shows antihypertensive efficacy. TA-606 can be used for hypertension research .
Cat. No.: HY-114961
CAS No.: 20897-92-1
Synonyms: 15-epi PGA1
Target:
Research Areas:
15-epi Prostaglandin A1 (15-epi PGA1) is the 15(R) stereoisomer of PGA1. PGA1 causes renal vasodilation, increased urine sodium excretion, and decreased arterial pressure in hypertensive models .
Cat. No.: HY-19145
CAS No.: 135704-06-2
Synonyms: CI-992
PD-134672 (CI-992) is a renin inhibitor containing a 2-amino-4-thiazolyl substituent. PD-134672 potently inhibits monkey renin in vitro and only weakly inhibits the related aspartic protease bovine feline hepsin D. The compound exhibits oral hypotensive activity in hyperreninemic normotensive monkeys. Based on its superior efficacy and long-lasting effects in vitro and in the normotensive macaque model, PD-134672 was selected for further evaluation in renal hypertensive monkeys.
Cat. No.: HY-162584
CAS No.: 3047956-65-7
Target:
Research Areas:
TRPC5-IN-6 (Compound 12) is an orally effective transient receptor potential (TRPC5) inhibitor with a IC50 value of 81 nM. TRPC5-IN-6 has good biosafety and low liver and kidney toxicity, and is expected to play an important role in the treatment of chronic kidney disease (CKD) .
Cat. No.: HY-B0202AS
Synonyms: SR-47436-d7 hydrochloride; BMS-186295-d7 hydrochloride
Cat. No.: HY-B0202S3
Synonyms: SR-47436-d7; BMS-186295-d7
Target:
Research Areas:
Pelanserin (Compound 1) is an orally active antihypertensive agent. Pelanserin is a potent 5-HT2 receptor antagonist. Pelanserin has the ability to block the activity of α-adrenergic receptor, with its ED50 being 0.03 μg/mL. Pelanserin has vasodilatory activity, with its ED100 being 5 μg. Pelanserin exhibits antihypertensive activity in hypertensive rats and renal hypertensive dog breeds. Pelanserin can be used for research on hypertension .
Cat. No.: HY-180322
CAS No.: 1592640-75-9
Target:
Research Areas:
TG2-IN-3h (Compound 3h) is a transglutaminase (TG2) inhibitor (hTG2: IC50 = 6nM). TG2-IN-3h inhibits endothelial cell migration and angiogenesis. TG2-IN-3h alleviates renal fibrosis in a mouse model of hypertensive nephropathy. TG2-IN-3h can be used in research on metabolic diseases such as hypertensive nephropathy and cardiovascular and cerebrovascular diseases such as pathological angiogenesis .
Cat. No.: HY-P2225
CAS No.: 35115-62-9
Research Areas:
Cat. No.: HY-180354
CAS No.: 86703-02-8
Synonyms: MDL-899
Target:
Research Areas:
Mopidralazine hydrochloride (MDL-899) (Compound 30) is an orally active antihypertensive agent. Mopidralazine hydrochloride significantly reduces systolic blood pressure (ED50 = 1.94 mg/kg) in spontaneously hypertensive rats models. Mopidralazine hydrochloride has a slower onset of action but a longer duration of action and has a significantly smaller effect on increasing heart rate in canine model of renal hypertension. Mopidralazine hydrochloride can be used for the research of hypertension .
Cat. No.: HY-187710
CAS No.: 80876-01-3
Synonyms: CI-907
Research Areas:
Indolapril (CI-907) is an orally active angiotensin-converting enzyme (ACE) inhibitor with an IC50 value of 80 nM. Indolapril exerts a highly specific functional inhibitory effect on Ang I-mediated pressor/contractile responses, and its antihypertensive effect correlates with ACE inhibition in vascular tissues. Indolapril reduces blood pressure in multiple rodent and canine models of hypertension. Indolapril exists as a monoester prodrug and an active diacid form, and no side effects are observed in tested conscious animals. Indolapril is applicable to hypertension-related research .
Cat. No.: HY-L145
930 compounds
The majority of hypertensive patients have primary (or essential) hypertension, that is, hypertension in which secondary causes are not present. Management aims to control arterial pressure, prevent end-organ damage (cerebrovascular, cardiovascular, and renal), and reduce the risk of premature death.
Antihypertensive drugs may be divided into two broad groups, the first group being those which directly or indirectly block the renin–angiotensin system (RAS), for example, ACEIs, angiotensin receptor antagonists (ARAs), direct renin inhibitors (DRIs), and to a lesser extent β-blockers. The second group of drugs works by increasing water and sodium excretion, thereby reducing intravascular volume, or by causing vasodilatation through non-RAS pathways, for example, diuretics and calcium channel blockers (CCBs).
MCE offers a unique collection of 930 compounds with identified and potential antihypertensive activity. MCE Antihypertensive Compound Library is critical for antihypertensive drug discovery and development.
Cat. No.: HY-117876
CAS No.: 119256-78-9
Synonyms: CV 2961
Target:
Research Areas:
S 8308 (CV 2961) is a non-peptide angiotensin II (Angiotensin II receptor) receptor antagonist with transient oral activity and short-acting intravenous activity, and exhibits an IC50 of 15 μM in rats. S 8308 competitively blocks the binding of angiotensin II to its receptor, thereby inhibiting vasoconstriction and pressor responses. S 8308 can be used in the research of hypertension and renal hypertension .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
