20897-92-1
20897-92-1
Chemical Structure
15-epi Prostaglandin A1
Synonym(s): 15-epi PGA1
- CAS. Nr.: 20897-92-1
- Formula:C20H32O4
- Molecular Weight:336.47
IUPAC Name: 7-((1R,2S)-2-((R,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopent-3-en-1-yl)heptanoic acid
InChIKey: BGKHCLZFGPIKKU-AHUSATQRSA-N
SMILES: CCCCC[C@H](/C=C/[C@@H](C=CC1=O)[C@H]1CCCCCCC(O)=O)O
Biological Activity: 15-epi Prostaglandin A1 (15-epi PGA1) is the 15(R) stereoisomer of PGA1. PGA1 causes renal vasodilation, increased urine sodium excretion, and decreased arterial pressure in hypertensive models[1][2].
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15-epi Prostaglandin A1 | 15-epi Prostaglandin A1 (15-epi PGA1) is the 15(R) stereoisomer of PGA1. PGA1 causes renal vasodilation, increased urine sodium excretion, and decreased arterial pressure in hypertensive models. | |||||||||||||||||||||
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References
- [1]. Murakami A, et al. Conformational analysis of prastaglandins. III. Study on active sites and conformation-action relationship. Chem Pharm Bull (Tokyo). 1977 Dec;25(12):3155-62. [Content Brief]
- [2]. Krakoff LR, et al. Differential effect of prostaglandin A1 in hypertensive patients with low, normal and high renin. Clin Sci Mol Med Suppl. 1975 Jun;2:311s-313s. [Content Brief]
