139958-16-0
Chemical Structure
ME3221
- CAS No.: 139958-16-0
- Formula:C22H21N5O2
- Molecular Weight:387.43
IUPAC Name: 4-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methoxy)-3-methoxy-2,6-dimethylpyridine
InChIKey: FTDRSCZZEUAAIP-UHFFFAOYSA-N
SMILES: COC1=C(C=C(C)N=C1C)OCC2=CC=C(C=C2)C3=C(C=CC=C3)C4=NN=NN4
Biological Activity: ME3221 is an angiotensin AT1 receptor antagonist that effectively antagonizes the pressor response to angiotensin II in rats and marmosets without affecting the hypotensive response to bradykinin. It demonstrates potent antihypertensive effects in renal hypertensive rats and spontaneously hypertensive rats (SHR). ME3221's repeated administration in SHR results in sustained and stable hypotensive effects without affecting heart rate, indicating its potential for studying both renal and essential hypertension[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
ME3221 | ME3221 is an angiotensin AT1 receptor antagonist that effectively antagonizes the pressor response to angiotensin II in rats and marmosets without affecting the hypotensive response to bradykinin. It demonstrates potent antihypertensive effects in renal hypertensive rats and spontaneously hypertensive rats (SHR). ME3221's repeated administration in SHR results in sustained and stable hypotensive effects without affecting heart rate, indicating its potential for studying both renal and essential hypertension. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
