1113-10-6
Chemical Structure
Guancydine
Synonym(s): Guancidine
- CAS No.: 1113-10-6
- Formula:C7H14N4
- Molecular Weight:154.21
InChIKey: VZVGEDRCVUKSEL-UHFFFAOYSA-N
SMILES: N=C(NC(C)(C)CC)NC#N
Biological Activity: Guancydine (Guancidine) is an orally active antihypertensive agent and vasodilator. Guancydine antagonizes the pressor effects of Angiotensin and Norepinephrine (HY-13715). Guancydine induces vasodilation in renal, mesenteric and cranial vascular beds, reduces peripheral resistance, increases cardiac output and lowers arterial blood pressure. Guancydine increases renal and forearm blood flow, reduces renal and forearm vascular resistance, alters cardiac systolic time, and reverses myocardial hypertrophy in hypertensive rats. Guancydine is applicable for research related to hypertension[1][2][3][4].
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Guancydine | 98.0% | Guancydine (Guancidine) is an orally active antihypertensive agent and vasodilator. Guancydine antagonizes the pressor effects of Angiotensin and Norepinephrine (HY-13715). Guancydine induces vasodilation in renal, mesenteric and cranial vascular beds, reduces peripheral resistance, increases cardiac output and lowers arterial blood pressure. Guancydine increases renal and forearm blood flow, reduces renal and forearm vascular resistance, alters cardiac systolic time, and reverses myocardial hypertrophy in hypertensive rats. Guancydine is applicable for research related to hypertension. | ||||||||||||||||||||
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- [1]. Hammer J, et al. Hemodynamic and therapeutic effects of guancydine in hypertension. Clin Pharmacol Ther. 1971 Jan-Feb;12(1):78-90. [Content Brief]
- [2]. Cummings JR, et al. Cardiovascular actions of guancydine in normotensive and hypertensive animals. J Pharmacol Exp Ther. 1968 May;161(1):88-97. PMID: 4296847. [Content Brief]
- [3]. Cummings JR, et al. Angiotensin blocking actions of guancydine. J Pharmacol Exp Ther. 1969 Dec;170(2):334-46.
- [4]. Pettinger W, Sheppard H, Palkoski Z, Renyi E. Angiotensin antagonism and antihypertensive activity of phosphodiesterase inhibiting agents. Life Sci I. 1973 Jan 15;12(2):49-62. doi: 10.1016/0024-3205(73)90061-1. PMID: 4348855. [Content Brief]
Keywords
