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Results for "

secretory activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (2) Adrenergic Receptor (1) Apoptosis (13) Autophagy (10) Bacterial (8) Bombesin Receptor (1) Cholecystokinin Receptor (1) Drug Metabolite (1) DYRK (1) Endogenous Metabolite (1) ERK (1) GSK-3 (1) HDAC (2) Histamine Receptor (1) Isotope-Labeled Compounds (6) Neuropeptide Y Receptor (1) NF-κB (1) P2X Receptor (1) p38 MAPK (1) Phospholipase (12) Proton Pump (12) Reference Standards (9) Sec61 (1) Trk Receptor (1)
By Research Areas:	Cancer (16) Endocrinology (2) Inflammation/Immunology (30) Metabolic Disease (6) Neurological Disease (5)
Oligonucleotides:	Nucleotide Analogs (1) Adenine Nucleotide (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13402

Varespladib Maximum Cited Publications 9 Publications Verification LY315920	Phospholipase	Inflammation/Immunology
Varespladib (LY315920) is a potent and selective *group IIA, secretory* phospholipase A₂ (sPLA₂) inhibitor with an IC₅₀ of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2** activity in serum from various species including rat, rabbit, guinea pig and human with IC₅₀s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

HY-17507

Pantoprazole 4 Publications Verification BY1023; SKF96022	Proton Pump Autophagy Apoptosis Bacterial	Inflammation/Immunology Cancer
Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H ⁺/K ⁺-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-136177

Tris(2,4-di-tert-butylphenyl)phosphate	Phospholipase	Inflammation/Immunology
Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A₂ (sPLA₂) through molecular docking .

HY-N7036

Rhamnetin 1 Publications Verification	Phospholipase HDAC Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2 and histone deacetylase 2 (HDAC2). Rhamnetin exhibits antitumor, antioxidant and anti-inflammatory activity .

HY-N8211

Gypenoside L 4 Publications Verification	p38 MAPK ERK NF-κB	Inflammation/Immunology Cancer
Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L increases the SA-β-galactosidase activity, promotes the production of senescence-associated secretory cytokines. Gypenoside L also can activate p38 and ERK MAPK pathways and NF-κB pathway to induce senescence. Gypenoside L exhibits anti-tumor and anti-inflammatory activities .

HY-17507B

Pantoprazole sodium hydrate 4 Publications Verification BY1023 sodium hydrate; SKF96022 sodium hydrate	Proton Pump Autophagy Apoptosis Bacterial	Inflammation/Immunology Cancer
Pantoprazole sodium hydrate (BY10232 sodium hydrate) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole sodium hydrate, a substituted benzimidazole, is a potent H ⁺/K ⁺-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole sodium hydrate improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium hydrate significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-17507A

Pantoprazole sodium 4 Publications Verification BY1023 sodium; SKF96022 sodium	Proton Pump Autophagy Apoptosis Bacterial	Inflammation/Immunology Cancer
Pantoprazole sodium (BY10232 sodium) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole sodium, a substituted benzimidazole, is a potent H ⁺/K ⁺-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole sodium improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-113273A

Diadenosine pentaphosphate pentasodium	P2X Receptor	Neurological Disease
Diadenosine pentaphosphate pentasodium is an agonist and negative modulator of the P2X1 receptor, an endogenous vasoactive purine dinucleotide that can be isolated from platelets. Diadenosine pentaphosphate pentasodium mediates negative regulation of dendrite growth and number by activating homologous and heterologous P2X1 receptors, which triggers a transient and moderate increase in intracellular calcium levels within dendritic growth cones. Diadenosine pentaphosphate pentasodium is widely present in secretory vesicles such as platelets, chromaffin cells and brain synaptosomes, and exhibits selective activity on dendrite growth of cultured hippocampal neurons, inhibiting only dendrite growth without affecting axon growth. Diadenosine pentaphosphate pentasodium has a weaker ability to compete with RcCHAD for binding to polyP than short-chain polyPs .

HY-11059

KH064	Phospholipase	Inflammation/Immunology
KH064, a D-tyrosine derivative, is an orally active, potent secretory phospholipase A₂ (sPLA₂) inhibitor with an IC₅₀ of 29 nM for human nonpancreatic secretory PLA₂ isoform IIa (hnpsPLA₂-IIa). KH064 has anti-inflammatory activity .

HY-107572

PD 128042 CI 976	Acyltransferase	Metabolic Disease
PD 128042 (CI 976) is a potent, orally active, and selective inhibitor of ACAT (acyl coenzyme A:cholesterol acyltransferase) with an IC₅₀s of 73 nM. PD 128042 is also a potent LPAT (lysophospholipid acyltransferase) inhibitor. PD 128042 inhibits Golgi-associated LPAT activity (IC₅₀=15 μM). PD 128042 inhibits multiple membrane trafficking steps, including ones found in the endocytic and secretory pathway .

HY-P4060

Pancreatic polypeptide	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
Pancreatic polypeptide is a peptide secreted by the endocrine PP cells of the pancreas that regulates pancreatic secretory activity and also affects hepatic glycogen stores and gastrointestinal secretion .

HY-13402A

Varespladib sodium Maximum Cited Publications 9 Publications Verification LY315920 sodium	Phospholipase	Inflammation/Immunology
Varespladib sodium (LY315920 sodium) is a potent and selective *group IIA, secretory* phospholipase A₂ (sPLA₂) inhibitor with an IC₅₀ of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on sPLA2** activity in serum from various species including rat, rabbit, guinea pig and human with IC₅₀s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

HY-N7031

(±)-Vasicine (±)-Peganine	Proton Pump	Inflammation/Immunology
(±)-Vasicine is the racemate of Vasicine. Vasicine (Peganine) significantly inhibits H ⁺-K ⁺-ATPase activity in vitro with an IC₅₀ of 73.47 μg/mL. Anti-ulcer activity. Vasicine shows significant anti-secretory, antioxidant and cytoprotective effect .

HY-17507AR

Pantoprazole sodium (Standard) BY1023 sodium (Standard); SKF96022 sodium (Standard)	Reference Standards Proton Pump Autophagy Apoptosis Bacterial	Inflammation/Immunology Cancer
Pantoprazole (sodium) (Standard) is the analytical standard of Pantoprazole (sodium). This product is intended for research and analytical applications. Pantoprazole sodium (BY10232 sodium) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole sodium, a substituted benzimidazole, is a potent H ⁺/K ⁺-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole sodium improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-17507S

Pantoprazole-d6 BY1023-d₆; SKF96022-d₆	Isotope-Labeled Compounds Proton Pump Autophagy Apoptosis	Inflammation/Immunology Cancer
Pantoprazole-d₆ is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-136177R

Tris(2,4-di-tert-butylphenyl)phosphate (Standard)	Reference Standards Phospholipase	Inflammation/Immunology
Tris(2,4-di-tert-butylphenyl)phosphate (Standard) is the analytical standard of Tris(2,4-di-tert-butylphenyl)phosphate. This product is intended for research and analytical applications. Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A2 (sPLA2) through molecular docking .

HY-17507R

Pantoprazole (Standard) BY1023 (Standard); SKF96022 (Standard)	Reference Standards Proton Pump Autophagy Apoptosis Bacterial	Inflammation/Immunology Cancer
Pantoprazole (Standard) is the analytical standard of Pantoprazole. This product is intended for research and analytical applications. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H ⁺/K ⁺-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-17507BR

Pantoprazole sodium hydrate (Standard) BY1023 sodium hydrate (Standard); SKF96022 sodium hydrate (Standard)	Reference Standards Proton Pump Autophagy Apoptosis Bacterial	Inflammation/Immunology Cancer
Pantoprazole (sodium hydrate) (Standard) is the analytical standard of Pantoprazole (sodium hydrate). This product is intended for research and analytical applications. Pantoprazole sodium hydrate (BY10232 sodium hydrate) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole sodium hydrate, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole sodium hydrate improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium hydrate significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-N17272

Cholic acid 3-sulfate	Drug Metabolite	Metabolic Disease
Cholic acid 3-sulfate is the sulfated metabolite of Cholic acid (HY-N0324), produced by liver enzyme sulfotransferase-2A1. Cholic acid 3-sulfate is less toxic than the parent compound, thus serving as a detoxification pathway for bile acids. Cholic acid 3-sulfate does not have the effect of stimulating intestinal secretion .

HY-13402S

Varespladib-d7 LY315920-d₇	Isotope-Labeled Compounds Phospholipase	Inflammation/Immunology
Varespladib-d₇ (LY315920-d₇) is a deuterated labeled Varespladib (HY-13402). Varespladib is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC₅₀ of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC₅₀s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

HY-N10763

N-Methylcorydaldine	Others	Endocrinology
N-Methylcorydaldine, an alkaloid, shows promising anti-secretory activity .

HY-108132

Ro 23-9358	Phospholipase	Inflammation/Immunology
Ro 23-9358 is a potent secretory phospholipase A2 inhibitor with anti-inflammatory activity .

HY-121406

(Z)-Lafutidine (Z)-FRG-8813	Histamine Receptor	Inflammation/Immunology
(Z)-Lafutidine ((Z)-FRG-8813) is a potent histamine H2 receptor antagonist. (Z)-Lafutidine shows anti-secretory and gastroprotective activities .

HY-N7031R

(±)-Vasicine (Standard) (±)-Peganine (Standard)	Reference Standards Proton Pump	Inflammation/Immunology
(±)-Vasicine (Standard) is the analytical standard of (±)-Vasicine (HY-N7031). This product is intended for research and analytical applications. (±)-Vasicine is the racemate of Vasicine. Vasicine (Peganine) significantly inhibits H+-K+-ATPase activity in vitro with an IC₅₀ of 73.47 μg/mL. Anti-ulcer activity. Vasicine shows significant anti-secretory, antioxidant and cytoprotective effect .

HY-N7036R

Rhamnetin (Standard)	Reference Standards Phospholipase HDAC Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Rhamnetin (Standard) is the analytical standard of Rhamnetin. This product is intended for research and analytical applications. Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2 and histone deacetylase 2 (HDAC2). Rhamnetin exhibits antitumor, antioxidant and anti-inflammatory activity .

HY-120381

PD 136450 CAM 1189	Cholecystokinin Receptor	Neurological Disease Inflammation/Immunology
PD 136450 (CAM 1189) is an antagonist for cholecystokinin 2 (CCK2). PD 136450 exhibits anti-secretory, anxiolytic and anti-ulcer activities, inhibits gastric acid secretion (IC₅₀=1 mg/kg), and ameliorates the haemorrhagic lesions (IC₅₀=4.7 mg/kg) in rats .

HY-17507S1

Pantoprazole-d3 BY1023-d₃; SKF96022-d₃	Isotope-Labeled Compounds Proton Pump Autophagy Apoptosis	Inflammation/Immunology Cancer
Pantoprazole-d₃ is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-13402R

Varespladib (Standard) LY315920 (Standard)	Phospholipase Reference Standards	Inflammation/Immunology
Varespladib (Standard) is the analytical standard of Varespladib. This product is intended for research and analytical applications. Varespladib (LY315920) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

HY-13402AR

Varespladib sodium (Standard) LY315920 sodium (Standard)	Phospholipase Reference Standards	Inflammation/Immunology
Varespladib (sodium) (Standard) is the analytical standard of Varespladib (sodium). This product is intended for research and analytical applications. Varespladib sodium (LY315920 sodium) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

HY-P10267

Neuromedin (B-30)	Bombesin Receptor	Neurological Disease Inflammation/Immunology
Neuromedin B-30 is the neuropeptide, which is orignally isolated from porcine brain and spinal cord. , and may exhibit activity in stimulating smooth-muscle. Neuromedin B causes local vasodilation, increases vascular permeability and local hyperalgesia, thereby participating in neurogenic inflammation. Neuromedin B regulates appetite, body temperature, and behavioral responses to stress. Neuromedin B is also involved in regulating smooth muscle contraction and secretory function in the gastrointestinal tract .

HY-W739793

Pantoprazole-d8 sodium BY1023-d8 sodium; SKF96022-d8 sodium	Isotope-Labeled Compounds Proton Pump Autophagy Apoptosis Bacterial	Inflammation/Immunology Cancer
Pantoprazole-d₈ (BY1023-d₈) sodium is a deuterium labeled Pantoprazole (HY-17507). Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H ⁺/K ⁺-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-17507S4

Pantoprazole-d4 BY1023-d₄; SKF96022-d₄	Isotope-Labeled Compounds	Inflammation/Immunology Cancer
Pantoprazole-d₄ (BY1023-d₄) is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H ⁺/K ⁺-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-17507S2

Pantoprazole-d8 BY1023-d₈; SKF96022-d₈	Isotope-Labeled Compounds Bacterial Autophagy Apoptosis Proton Pump	Inflammation/Immunology Cancer
Pantoprazole-d₈ (BY1023-d₈) is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H ⁺/K ⁺-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-107572R

PD 128042 (Standard) CI 976 (Standard)	Acyltransferase Reference Standards	Metabolic Disease
PD 128042 (Standard) is the analytical standard of PD 128042. This product is intended for research and analytical applications. PD 128042 (CI 976) is a potent, orally active, and selective inhibitor of ACAT (acyl coenzyme A:cholesterol acyltransferase) with an IC50s of 73 nM. PD 128042 is also a potent LPAT (lysophospholipid acyltransferase) inhibitor. PD 128042 inhibits Golgi-associated LPAT activity (IC50=15 μM). PD 128042 inhibits multiple membrane trafficking steps, including ones found in the endocytic and secretory pathway .

HY-118935

NGD9002 free base	Adrenergic Receptor	Inflammation/Immunology
NGD9002 free base is a new generation of selective corticotropin-releasing factor-1 (CRF-1) receptor antagonist with inhibitory activity on CRF-induced colonic function stimulation. NGD9002 free base can reduce CRF-induced fecal output response and show an inhibitory IC50 value of 4.3 mg/kg. NGD9002 free base can effectively block CRF-induced colonic secretory motility stimulation at the highest dose and reduce acute water avoidance-induced defecation. NGD9002 free base can also prevent the occurrence of pain hypersensitivity reactions to repeated colonic distension .

HY-133233

Thioetheramide-PC 1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine	Endogenous Metabolite Phospholipase	Metabolic Disease
Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) is a structurally modified phospholipid that acts as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2). Thioetheramide-PC has an IC₅₀ value of 2 μM at a substrate concentration of 0.5 mM. In addition to binding to the catalytic site of sPLA2, Thioetheramide-PC also binds to the activation site of the enzyme. Thioetheramide-PC binds more tightly to the activation site than to the catalytic site. As a result of this dual interaction, at low concentrations, Thioetheramide-PC may activate phospholipase activity rather than inhibit it.

HY-175302

TRK-IN-32	Trk Receptor Apoptosis	Cancer
TRK-IN-32 is a potent TRK inhibitor. TRK-IN-32 potently inhibits TRK ^WT, TRK ^G595R and TRK ^G667C with IC₅₀ values of 0.08 nM, 2.14 nM and 0.68 nM, respectively. TRK-IN-32 also demonstrates antiproliferative activity against a panel of Ba/F3 cell lines transformed with wild type, xDFG, solvent-front as well as gatekeeper mutant TRK fusion proteins. TRK-IN-32 induces apoptosis of Ba/F3-TRKA ^WT and Ba/F3-TRKA ^G667C cells.TRK-IN-32 can be used for the study of various cancers (such as thyroid cancer, secretory breast carcinoma) .

HY-158792

GK241	Others	Others
GK241 (compound 31a-c) is a 2-oxoamide-based compound that has inhibitory activity against human and mouse group IIA secretory phospholipase A2 (GIIA sPLA2) (IC₅₀ of 143 nM and 68 nM, respectively), and its inhibitory mechanism was studied by molecular dynamics simulation.

HY-P3987A

Cotransin TFA	Sec61	Cancer
Cotransin TFA is a cyclic ester peptide and a Sec61 translocator binder with signal sequence-selective activity to inhibit co-translational protein translocation. Cotransin TFA inhibits the biogenesis of a subset of secretory and membrane proteins in a signal peptide-dependent manner. Cotransin TFA is applicable for cancer-related research .

HY-183955

GNF7156	DYRK GSK-3	Metabolic Disease Inflammation/Immunology
GNF7156 is a DYRK1A/GSK3B inhibitor, IC₅₀ values of 100 nM for DYRK1A and 40 nM for GSK3B. GNF7156 inhibits DYRK1A and GSK3B kinase activity and induces NFAT nuclear retention. GNF7156 stimulates beta-cell cycle entry and division and maintains insulin secretory capacity. GNF7156 can be used for the research of type 1 diabetes, and type 2 diabetes .

Cat. No.	Product Name	Target	Research Area

HY-P4060

Pancreatic polypeptide	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
Pancreatic polypeptide is a peptide secreted by the endocrine PP cells of the pancreas that regulates pancreatic secretory activity and also affects hepatic glycogen stores and gastrointestinal secretion .

HY-P10267

Neuromedin (B-30)	Bombesin Receptor	Neurological Disease Inflammation/Immunology
Neuromedin B-30 is the neuropeptide, which is orignally isolated from porcine brain and spinal cord. , and may exhibit activity in stimulating smooth-muscle. Neuromedin B causes local vasodilation, increases vascular permeability and local hyperalgesia, thereby participating in neurogenic inflammation. Neuromedin B regulates appetite, body temperature, and behavioral responses to stress. Neuromedin B is also involved in regulating smooth muscle contraction and secretory function in the gastrointestinal tract .

HY-P3987A

Cotransin TFA	Sec61	Cancer
Cotransin TFA is a cyclic ester peptide and a Sec61 translocator binder with signal sequence-selective activity to inhibit co-translational protein translocation. Cotransin TFA inhibits the biogenesis of a subset of secretory and membrane proteins in a signal peptide-dependent manner. Cotransin TFA is applicable for cancer-related research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-136177

Tris(2,4-di-tert-butylphenyl)phosphate	Natural Products Verbenaceae Plants Inflammation/Immunology Disease Research Fields Source Classification Vitex negundo Linn.	Phospholipase
Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A₂ (sPLA₂) through molecular docking .

HY-N7036

Rhamnetin 1 Publications Verification	Flavonols Flavonoids Classification of Application Fields Phenols Polyphenols Amberboa moschata (L.) DC. Umbelliferae Plants Inflammation/Immunology Disease Research Fields Source Classification	Phospholipase HDAC Apoptosis
Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2 and histone deacetylase 2 (HDAC2). Rhamnetin exhibits antitumor, antioxidant and anti-inflammatory activity .

HY-N8211

Gypenoside L 4 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino Inflammation/Immunology Disease Research Fields Source Classification	p38 MAPK ERK NF-κB
Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L increases the SA-β-galactosidase activity, promotes the production of senescence-associated secretory cytokines. Gypenoside L also can activate p38 and ERK MAPK pathways and NF-κB pathway to induce senescence. Gypenoside L exhibits anti-tumor and anti-inflammatory activities .

HY-N7031

(±)-Vasicine (±)-Peganine	Alkaloids Classification of Application Fields Other Alkaloids Zygophyllaceae Peganum harmala Linn. Plants Inflammation/Immunology Disease Research Fields Source Classification	Proton Pump
(±)-Vasicine is the racemate of Vasicine. Vasicine (Peganine) significantly inhibits H ⁺-K ⁺-ATPase activity in vitro with an IC₅₀ of 73.47 μg/mL. Anti-ulcer activity. Vasicine shows significant anti-secretory, antioxidant and cytoprotective effect .

HY-136177R

Tris(2,4-di-tert-butylphenyl)phosphate (Standard)	Natural Products Verbenaceae Plants Source Classification Vitex negundo Linn.	Reference Standards Phospholipase
Tris(2,4-di-tert-butylphenyl)phosphate (Standard) is the analytical standard of Tris(2,4-di-tert-butylphenyl)phosphate. This product is intended for research and analytical applications. Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A2 (sPLA2) through molecular docking .

HY-N17272

Cholic acid 3-sulfate	Structural Classification Endogenous metabolite Steroids Source Classification	Drug Metabolite
Cholic acid 3-sulfate is the sulfated metabolite of Cholic acid (HY-N0324), produced by liver enzyme sulfotransferase-2A1. Cholic acid 3-sulfate is less toxic than the parent compound, thus serving as a detoxification pathway for bile acids. Cholic acid 3-sulfate does not have the effect of stimulating intestinal secretion .

HY-N10763

N-Methylcorydaldine	Michelia figo (Lour.) Spreng. Magnoliaceae Plants Source Classification	Others
N-Methylcorydaldine, an alkaloid, shows promising anti-secretory activity .

HY-N7031R

(±)-Vasicine (Standard) (±)-Peganine (Standard)	Alkaloids Structural Classification Other Alkaloids Zygophyllaceae Peganum harmala Linn. Plants Source Classification	Reference Standards Proton Pump
(±)-Vasicine (Standard) is the analytical standard of (±)-Vasicine (HY-N7031). This product is intended for research and analytical applications. (±)-Vasicine is the racemate of Vasicine. Vasicine (Peganine) significantly inhibits H+-K+-ATPase activity in vitro with an IC₅₀ of 73.47 μg/mL. Anti-ulcer activity. Vasicine shows significant anti-secretory, antioxidant and cytoprotective effect .

HY-N7036R

Rhamnetin (Standard)	Flavonols Structural Classification Flavonoids Phenols Polyphenols Amberboa moschata (L.) DC. Umbelliferae Plants Source Classification	Reference Standards Phospholipase HDAC Apoptosis
Rhamnetin (Standard) is the analytical standard of Rhamnetin. This product is intended for research and analytical applications. Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2 and histone deacetylase 2 (HDAC2). Rhamnetin exhibits antitumor, antioxidant and anti-inflammatory activity .

Cat. No.	Product Name	Chemical Structure

HY-17507S

Pantoprazole-d6

Pantoprazole-d₆ is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-13402S

Varespladib-d7

Varespladib-d₇ (LY315920-d₇) is a deuterated labeled Varespladib (HY-13402). Varespladib is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC₅₀ of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC₅₀s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

HY-17507S1

Pantoprazole-d3

Pantoprazole-d₃ is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-W739793

Pantoprazole-d8 sodium

Pantoprazole-d₈ (BY1023-d₈) sodium is a deuterium labeled Pantoprazole (HY-17507). Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H ⁺/K ⁺-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-17507S4

Pantoprazole-d4

Pantoprazole-d₄ (BY1023-d₄) is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H ⁺/K ⁺-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-17507S2

Pantoprazole-d8

Pantoprazole-d₈ (BY1023-d₈) is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H ⁺/K ⁺-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

Host:	Mouse (1) Rabbit (1)
Reactivity:	Human (2) Rat (1) Mouse (1)
Application:	IHC-P (1) ICC/IF (1) WB (2)
Isotype:	IgG (1) IgG1 (1)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

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HY-P86829

	CXCL1/GRO alpha Antibody (YA6522) C-X-C motif chemokine 1 antibody; Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) antibody; chemokine (C-X-C motif) ligand 1 antibody; CINC-1 antibody; CXCL1 antibody; Cytokine-induced neutrophil chemoattractant 1 antibody; Fibroblast secretory protein antibody; Fsp antibody; Gro 1 antibody; Gro A antibody; C-X-C motif chemokine 1 antibody; Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) antibody; chemokine (C-X-C motif) ligand 1 antibody; CINC-1 antibody; CXCL1 antibody; Cytokine-induced neutrophil chemoattractant 1 antibody; Fibroblast secretory protein antibody; Fsp antibody; Gro 1 antibody; Gro A antibody; Gro antibody; GRO protein, alpha antibody; GRO-alpha(1-73) antibody; GRO-alpha(6-73) antibody; Gro1 antibody; GRO1 oncogene (melanoma growth stimulating activity, alpha) antibody; GRO1 oncogene (melanoma growth-stimulating activity) antibody; Gro1 oncogene antibody; GROa antibody; GROA_HUMAN antibody; Growth-regulated alpha protein antibody; KC antibody; KC chemokine, mouse, homolog of antibody; melanoma growth stimulatory activity alpha antibody; Melanoma growth stimulatory activity antibody; Melanoma growth stimulatory activity, alpha antibody; MGSA alpha antibody; MGSA antibody; MGSA-a antibody; N51 antibody; NAP-3 antibody; NAP3 antibody; Neutrophil-activating protein 3 antibody; Platelet-derived growth factor-inducible protein KC antibody; Scyb 1 antibody; Scyb1 antibody; secretory protein N51 antibody; Small inducible cytokine subfamily B, member 1 antibody;	WB	Human
	CXCL1/GRO alpha Antibody (YA6522) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CXCL1/GRO alpha.

HY-P86889

	GNAS Antibody (YA6582) Adenylate cyclase stimulating G alpha protein antibody; AHO antibody; Alternative gene product encoded by XL exon antibody; C20orf45 antibody; dJ309F20.1.1 antibody; dJ806M20.3.3 antibody; Extra large alphas protein antibody; GNAS antibody; GNAS complex locus antibody; GNAS1 antibody; Adenylate cyclase stimulating G alpha protein antibody; AHO antibody; Alternative gene product encoded by XL exon antibody; C20orf45 antibody; dJ309F20.1.1 antibody; dJ806M20.3.3 antibody; Extra large alphas protein antibody; GNAS antibody; GNAS complex locus antibody; GNAS1 antibody; GPSA antibody; Gs alpha subunit antibody; GSA antibody; GSP antibody; Guanine nucleotide binding protein (G protein) alpha stimulating activity polypeptide 1 antibody; Guanine nucleotide binding protein alpha stimulating activity polypeptide 1 antibody; Guanine nucleotide binding protein G(s) subunit alpha isoforms short antibody; Guanine nucleotide binding protein G(s) subunit alpha isoforms XLas antibody; Guanine nucleotide regulatory protein antibody; MGC33735 antibody; NESP antibody; NESP55 antibody; Neuroendocrine secretory protein antibody; PHP1A antibody; PHP1B antibody; PHP1C antibody; POH antibody; Protein ALEX antibody; Protein GNAS antibody; Protein NESP55 antibody; SCG6 antibody; Secretogranin VI antibody; XLalphas antibody; XLas antibody;	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	GNAS Antibody (YA6582) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GNAS.

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