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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
senescence-associated β-galactosidase
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "senescence-associated β-galactosidase" in MCE Product Catalog:
4
4 Cited Publications
Cat. No.: HY-N8211
CAS No.: 94987-09-4
Cat. No.: HY-165424
CAS No.: 3036456-18-2
Target:
Cat. No.: HY-182898
CAS No.: 3051812-84-8
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Gal-dMor-Gem is a selective senescent cell scavenger, Apoptosis inducer, and a prodrug of Gemcitabine (HY-17026). Gal-dMor-Gem releases Gemcitabine upon activation by Esterases and β-gal. Gal-dMor-Gem reduces SA-β-gal, preferentially induces apoptosis in senescent cells, regulates apoptosis-related proteins, accumulates in senescent tissues, and ameliorates senescence-related organ phenotypes. Gal-dMor-Gem is applicable to research on chemotherapy-induced senescence .
Cat. No.: HY-188142
CAS No.: 259684-23-6
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Gal-PAB is a galactose-linker conjugate that can be used for the synthesis of the galactose-modified PROTAC prodrug Gal-ARV-771 (HY-158331). Gal-PAB is applicable to lung cancer research .
Cat. No.: HY-187365
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Research Areas:
UCM-17017 is a tetrasubstituted cyclohexene inhibitor that inhibits the activity of senescent cell SA-β-gal with an IC50 of 0.4 μM. UCM-17017 selectively reduces the viability of senescent cancer cells, and this effect is stronger than its impact on proliferating cells. UCM-17017 binds to human serum albumin with a KD of 230 μM. UCM-17017 reduces collagen deposition and decreases the expression of the inflammatory marker Ccl2 in a mouse model of pulmonary fibrosis. UCM-17017 can be used in studies related to senescence and pulmonary fibrosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
