69 Results for "

steroidal saponin

" in MedChemExpress (MCE) Product Catalog:
Products (69)

69 Results for "steroidal saponin" in MCE Product Catalog:

11
Diosgenin
Diosgenin
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11 Publications Verification
Cat. No.: HY-N0177
CAS No.: 512-04-9
Category:  

Human Gut Microbiota Metabolites other families Metabolic Disease Plants Endogenous metabolite Disease Research Fields Steroids

Target:  

STAT MicroRNA

Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway . Diosgenin is an exogenous activator of Pdia3/ERp57 . Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression .
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11
Dioscin
Dioscin
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11 Publications Verification
Cat. No.: HY-N0124
CAS No.: 19057-60-4
Synonyms: Collettiside III; CCRIS 4123
Category:  

other families Plants Disease Research Fields Cancer Steroids

Target:  

Autophagy Apoptosis

Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .
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5
Paris saponin VII
Paris saponin VII
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5 Cited Publications
Cat. No.: HY-N3584
CAS No.: 68124-04-9
Synonyms: Chonglou saponin VII
Category:  

Liliaceae  Trillium tschonoskii Maxim. Plants Disease Research Fields Cancer Steroids

Target:  

Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis

Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .
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2
Gracillin
Gracillin
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2 Cited Publications
Cat. No.: HY-N0706
CAS No.: 19083-00-2
Category:  

other families Plants Disease Research Fields Cancer Steroids

Target:  

Apoptosis Autophagy

Gracillin is a steroidal saponin that can be extracted from the roots of the plant and has anti-tumor properties. Gracillin can induce cancer cell apoptosis and autophagy .
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2
Timosaponin BII
Timosaponin BII
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2 Cited Publications
Cat. No.: HY-N0812
CAS No.: 136656-07-0
Synonyms: Prototimosaponin A III
Category:  

Liliaceae Neurological Disease Anemarrhena asphodeloides Bunge Plants Disease Research Fields Inflammation/Immunology Steroids

Target:  

Amyloid-β

Timosaponin BII (Prototimosaponin A III) is a steroid saponin found in the rhizomes of Anemarrhena asphodeloides. Timosaponin BII has neuronal protective, anti-inflammatory and antioxidant activities .
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1
Hecogenin
Hecogenin
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1 Cited Publications
Cat. No.: HY-N1422
CAS No.: 467-55-0
Category:  

Agavaceae Plants Agave sisalana Perr. ex Engelm. Disease Research Fields Inflammation/Immunology Steroids

Target:  

Fungal

Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects .
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1
Liriopesides B
Liriopesides B
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1 Cited Publications
Cat. No.: HY-N5135
CAS No.: 87425-34-1
Synonyms: Nolinospiroside F
Category:  

Liliaceae Anti-aging Other Diseases Liriope spicata (Thunb.) Lour. Plants Disease Research Fields Steroids

Target:  

Others

Liriopesides B (Nolinospiroside F) is a steroidal saponin isolated from Ophiopogon japonicas. Liriopesides B has anti-oxidative and anti-aging effects .
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1
Deltonin
Deltonin
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1 Cited Publications
Cat. No.: HY-N2283
CAS No.: 55659-75-1
Category:  

Dioscorea Zingiberensis C.H.Wright Plants Endogenous metabolite Disease Research Fields Cancer Dioscoreaceae Steroids

Target:  

ERK Akt Endogenous Metabolite

Deltonin, a steroidal saponin, isolated from Dioscorea zingiberensis, has antitumor activity; Deltonin inhibits ERK1/2 and AKT activation.
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1
Polyphyllin H
Polyphyllin H
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1 Cited Publications
Cat. No.: HY-N2382
CAS No.: 81917-50-2
Category:  

other families Plants Steroids

Target:  

Cytochrome P450 P-glycoprotein

Polyphyllin H is a steroidal saponin. Polyphyllin H is isolated from Paris polyphylla. Polyphyllin H potently inhibits the activities of CYP1A2 (IC50 = 6.44 μM, competitive), CYP2D6 (IC50 = 13.88 μM, competitive) and CYP3A4 (IC50 = 4.52 μM, non-competitive, time-dependent). Polyphyllin H downregulates the expression of ABCB1 and ABCC3. Polyphyllin H binds to membrane cholesterol and disrupts lipid raft structures. Polyphyllin H restores the sensitivity of paclitaxel-resistant breast cancer cells to paclitaxel .
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1
Anemarrhenasaponin A2
Anemarrhenasaponin A2
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1 Cited Publications
Cat. No.: HY-N7614
CAS No.: 117210-12-5
Synonyms: Schidigerasaponin F2; Timosaponin AII
Category:  

Cardiovascular Disease Liliaceae Anemarrhena asphodeloides Bunge Plants Disease Research Fields Steroids

Target:  

Others

Anemarrhenasaponin A2 (Schidigerasaponin F2) is a steroidal saponin isolated from the rhizomes of Anemarrhena asphodeloides. Anemarrhenasaponin A2 inhibits ADP-induced platelet aggregation .
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Protodioscin
Protodioscin
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Cat. No.: HY-N0799
CAS No.: 55056-80-9
Category:  

Leguminosae Plants Endogenous metabolite Disease Research Fields Trigonella foenum-graecum Linn. Cancer Steroids

Target:  

Endogenous Metabolite

Protodioscin, a major steroidal saponin in Trigonella foenum-graecum Linn., has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties.
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Shatavarin IV
Shatavarin IV
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Cat. No.: HY-N8804
CAS No.: 84633-34-1
Synonyms: Asparanin B
Category:  

Plants Asparagaceae Juss. Steroids

Target:  

Reactive Oxygen Species (ROS)

Shatavarin IV is a steroidal saponin, that can be isolated from the roots of Asparagus racemosus (Liliaceae). Shatavarin IV shows anticancer activity. Shatavarin IV elicits lifespan extension and alleviates Parkinsonism in Caenorhabditis elegans .
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Yamogenin
Yamogenin
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Cat. No.: HY-N2078
CAS No.: 512-06-1
Synonyms: Neodiosgenin
Category:  

other families Metabolic Disease Plants Disease Research Fields Steroids

Target:  

LXR Reactive Oxygen Species (ROS) Apoptosis Fatty Acid Synthase (FASN)

Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes. Yamogenin is a steroidal saponin that can be obtained from plant species with in vitro cytotoxicity, antioxidant, and antimicrobial properties. Yamogenin induces cell death via the extrinsic and intrinsic way of apoptosis. Yamogenin inhibits protein denaturation with an IC50 of 1421.92 μg/mL. Yamogenin can be studied in research on gastric cancer .
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Methyl protodioscin
Methyl protodioscin
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Cat. No.: HY-N0863
CAS No.: 54522-52-0
Synonyms: NSC-698790; Smilax saponin B
Category:  

other families Plants Disease Research Fields Cancer Steroids

Target:  

Bcl-2 Family Apoptosis Akt c-Myc ERK p38 MAPK JNK FOXO

Methyl protodioscin (NSC-698790; Smilax saponin B) is a multi-target, selective, steroidal diglycoside inhibitor with antitumor activity that induces cell cycle arrest. The mechanism of action of Methyl protodioscin is complex, involving the induction of G2/M cell cycle arrest, regulation of the Bcl-2/Bax apoptotic pathway, inhibition of the Akt1/c-Myc axis and MAPK/ERK signaling, while simultaneously downregulating ADAM15 and inducing FOXO1 to reduce cholesterol synthesis. It also inhibits the JNK/c-Jun pathway, reducing the production of inflammatory factors (IL-6, TNF-α). Methyl protodioscin exhibits significant antitumor (inhibiting proliferation, migration, invasion, and inducing apoptosis), anti-inflammatory, and anti-restenosis activities. Methyl protodioscin can be used in research on lung cancer, prostate cancer, pancreatic cancer, and other tumors, as well as inflammatory diseases such as airway inflammation and enteritis .
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Officinalisinin I
Officinalisinin I
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Cat. No.: HY-107284
CAS No.: 57944-18-0
Purity:  99.33%
Category:  

Liliaceae Other Diseases Anemarrhena asphodeloides Bunge Plants Disease Research Fields Steroids

Target:  

Others

Officinalisinin I is a steroidal saponin, isolated from Anemarrhena asphodeloides.
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Ophiopogonin D'
Ophiopogonin D'
0 Images
Cat. No.: HY-N3504
CAS No.: 65604-80-0
Category:  

Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Plants Disease Research Fields Cancer Steroids

Target:  

Sirtuin OAT

Ophiopogonin D' is a steroidal saponin and a SIRT1 activator. Ophiopogonin D' can also regulate the activities of transporters OATP1B1 and OATP1B3. Ophiopogonin D' exhibits certain toxicity to tumor cells. Ophiopogonin D' can be used in tumor research .
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Timosaponin B III
Timosaponin B III
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Cat. No.: HY-N6806
CAS No.: 142759-74-8
Category:  

Liliaceae Anemarrhena asphodeloides Bunge Plants Steroids

Target:  

Others

Timosaponin B III is a major bioactive steroidal saponin isolated from Anemarrhena asphodeloides Bge, and exhibits anti-inflammatory, anti-platelet aggregative and anti-depressive effects .
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Zingiberen newsaponin
Zingiberen newsaponin
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Cat. No.: HY-N2282
CAS No.: 91653-50-8
Synonyms: Zingiberensis newsaponin
Category:  

Cardiovascular Disease Triterpenes Terpenoids Dioscorea Zingiberensis C.H.Wright Plants Disease Research Fields Dioscoreaceae

Zingiberen Newsaponin (Zingiberensis newsaponin) is an orally active type of steroid saponin compound. Zingiberen Newsaponin exerts anti-hepatocellular carcinoma (HCC) effects by inhibiting autophagy and the AKR1C1/JAK2/STAT3 pathway. Zingiberen Newsaponin activates oxidative stress (upregulates ROS and MDA) and mitochondrial pathways, promoting cancer cell apoptosis. Zingiberen Newsaponin alleviates cerebral ischemia-reperfusion (I/R) injury by decreasing the concentration of pro-inflammatory cytokines and inhibits NF-κB. Zingiberen Newsaponin can enhance the activity of SOD, eliminate free radicals and protect nerve cells. Zingiberen Newsaponin induces platelet aggregation .
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Timosaponin A1
Timosaponin A1
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Cat. No.: HY-N6079
CAS No.: 68422-00-4
Category:  

Liliaceae Other Diseases Anemarrhena asphodeloides Bunge Plants Disease Research Fields Steroids

Target:  

Lipoxygenase Dipeptidyl Peptidase COX

Timosaponin A1, a natural steroidal saponin, is a 5-lipoxygenase (5-LO), COX-2, and dipeptidyl peptidase 4 (DPP-4) inhibitor with IC50s of 3.29 µM, 36.43 µM, and 33.25 µM, respectively .
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Protogracillin
Protogracillin
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Cat. No.: HY-N4271
CAS No.: 54848-30-5
Category:  

Cardiovascular Disease other families Plants Disease Research Fields Steroids

Target:  

Others

Protogracillin is a steroidal furostanol saponin. Protogracillin can be isolated from the rhizomes and tubers of Dioscorea zingiberensis C.H. Wright. Protogracillin is hydrolyzable to Prosapogenin A (HY-N6940). Protogracillin exhibits antithrombotic activity. Protogracillin can be used in research related to cardiovascular diseases .
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