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Results for "

steroidal saponin

" in MedChemExpress (MCE) Product Catalog:

66

Inhibitors & Agonists

63

Natural
Products

Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-N0177
    Diosgenin
    5+ Cited Publications

    STAT MicroRNA Metabolic Disease
    Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway . Diosgenin is an exogenous activator of Pdia3/ERp57 . Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression .
    Diosgenin
  • HY-N0124
    Dioscin
    Maximum Cited Publications
    11 Publications Verification

    Collettiside III; CCRIS 4123

    Autophagy Apoptosis Cardiovascular Disease Cancer
    Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .
    Dioscin
  • HY-N0706
    Gracillin
    2 Publications Verification

    Apoptosis Autophagy Cancer
    Gracillin is a steroidal saponin that can be extracted from the roots of the plant and has anti-tumor properties. Gracillin can induce cancer cell apoptosis and autophagy .
    Gracillin
  • HY-N0799

    Endogenous Metabolite Cardiovascular Disease Cancer
    Protodioscin, a major steroidal saponin in Trigonella foenum-graecum Linn., has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties.
    Protodioscin
  • HY-N3584
    Paris saponin VII
    4 Publications Verification

    Chonglou saponin VII

    Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis Cancer
    Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .
    Paris saponin VII
  • HY-N8804

    Asparanin B

    Reactive Oxygen Species (ROS) Neurological Disease Cancer
    Shatavarin IV is a steroidal saponin, that can be isolated from the roots of Asparagus racemosus (Liliaceae). Shatavarin IV shows anticancer activity. Shatavarin IV elicits lifespan extension and alleviates Parkinsonism in Caenorhabditis elegans .
    Shatavarin IV
  • HY-N1422
    Hecogenin
    1 Publications Verification

    Fungal Infection Inflammation/Immunology
    Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects .
    Hecogenin
  • HY-N2078

    Neodiosgenin

    LXR Reactive Oxygen Species (ROS) Apoptosis Fatty Acid Synthase (FASN) Metabolic Disease
    Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes. Yamogenin is a steroidal saponin that can be obtained from plant species with in vitro cytotoxicity, antioxidant, and antimicrobial properties. Yamogenin induces cell death via the extrinsic and intrinsic way of apoptosis. Yamogenin inhibits protein denaturation with an IC50 of 1421.92 μg/mL. Yamogenin can be studied in research on gastric cancer .
    Yamogenin
  • HY-N5135
    Liriopesides B
    1 Publications Verification

    Nolinospiroside F

    Others Others
    Liriopesides B (Nolinospiroside F) is a steroidal saponin isolated from Ophiopogon japonicas. Liriopesides B has anti-oxidative and anti-aging effects .
    Liriopesides B
  • HY-N0863

    NSC-698790; Smilax saponin B

    Bcl-2 Family Apoptosis Akt c-Myc ERK p38 MAPK JNK FOXO Cancer
    Methyl protodioscin (NSC-698790; Smilax saponin B) is a multi-target, selective, steroidal diglycoside inhibitor with antitumor activity that induces cell cycle arrest. The mechanism of action of Methyl protodioscin is complex, involving the induction of G2/M cell cycle arrest, regulation of the Bcl-2/Bax apoptotic pathway, inhibition of the Akt1/c-Myc axis and MAPK/ERK signaling, while simultaneously downregulating ADAM15 and inducing FOXO1 to reduce cholesterol synthesis. It also inhibits the JNK/c-Jun pathway, reducing the production of inflammatory factors (IL-6, TNF-α). Methyl protodioscin exhibits significant antitumor (inhibiting proliferation, migration, invasion, and inducing apoptosis), anti-inflammatory, and anti-restenosis activities. Methyl protodioscin can be used in research on lung cancer, prostate cancer, pancreatic cancer, and other tumors, as well as inflammatory diseases such as airway inflammation and enteritis .
    Methyl protodioscin
  • HY-107284

    Others Others
    Officinalisinin I is a steroidal saponin, isolated from Anemarrhena asphodeloides.
    Officinalisinin I
  • HY-N2283
    Deltonin
    1 Publications Verification

    ERK Akt Endogenous Metabolite Cancer
    Deltonin, a steroidal saponin, isolated from Dioscorea zingiberensis, has antitumor activity; Deltonin inhibits ERK1/2 and AKT activation.
    Deltonin
  • HY-N0812
    Timosaponin BII
    2 Publications Verification

    Prototimosaponin A III

    Amyloid-β Neurological Disease Inflammation/Immunology Cancer
    Timosaponin BII (Prototimosaponin A III) is a steroid saponin found in the rhizomes of Anemarrhena asphodeloides. Timosaponin BII has neuronal protective, anti-inflammatory and antioxidant activities .
    Timosaponin BII
  • HY-N3504

    Sirtuin OAT Cancer
    Ophiopogonin D' is a steroidal saponin and a SIRT1 activator. Ophiopogonin D' can also regulate the activities of transporters OATP1B1 and OATP1B3. Ophiopogonin D' exhibits certain toxicity to tumor cells. Ophiopogonin D' can be used in tumor research .
    Ophiopogonin D'
  • HY-N6806

    Others Neurological Disease Inflammation/Immunology
    Timosaponin B III is a major bioactive steroidal saponin isolated from Anemarrhena asphodeloides Bge, and exhibits anti-inflammatory, anti-platelet aggregative and anti-depressive effects .
    Timosaponin B III
  • HY-N2282

    Zingiberensis newsaponin

    Aldose Reductase JAK STAT Autophagy Apoptosis NF-κB SOD Reactive Oxygen Species (ROS) Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
    Zingiberen Newsaponin (Zingiberensis newsaponin) is an orally active type of steroid saponin compound. Zingiberen Newsaponin exerts anti-hepatocellular carcinoma (HCC) effects by inhibiting autophagy and the AKR1C1/JAK2/STAT3 pathway. Zingiberen Newsaponin activates oxidative stress (upregulates ROS and MDA) and mitochondrial pathways, promoting cancer cell apoptosis. Zingiberen Newsaponin alleviates cerebral ischemia-reperfusion (I/R) injury by decreasing the concentration of pro-inflammatory cytokines and inhibits NF-κB. Zingiberen Newsaponin can enhance the activity of SOD, eliminate free radicals and protect nerve cells. Zingiberen Newsaponin induces platelet aggregation .
    Zingiberen newsaponin
  • HY-N6079

    Lipoxygenase Dipeptidyl Peptidase COX Metabolic Disease Cancer
    Timosaponin A1, a natural steroidal saponin, is a 5-lipoxygenase (5-LO), COX-2, and dipeptidyl peptidase 4 (DPP-4) inhibitor with IC50s of 3.29 µM, 36.43 µM, and 33.25 µM, respectively .
    Timosaponin A1
  • HY-N4271

    Others Cardiovascular Disease
    Protogracillin is a steroidal furostanol saponin. Protogracillin can be isolated from the rhizomes and tubers of Dioscorea zingiberensis C.H. Wright. Protogracillin is hydrolyzable to Prosapogenin A (HY-N6940). Protogracillin exhibits antithrombotic activity. Protogracillin can be used in research related to cardiovascular diseases .
    Protogracillin
  • HY-N2382
    Polyphyllin H
    1 Publications Verification

    Cytochrome P450 P-glycoprotein Metabolic Disease Cancer
    Polyphyllin H is a steroidal saponin. Polyphyllin H is isolated from Paris polyphylla. Polyphyllin H potently inhibits the activities of CYP1A2 (IC50 = 6.44 μM, competitive), CYP2D6 (IC50 = 13.88 μM, competitive) and CYP3A4 (IC50 = 4.52 μM, non-competitive, time-dependent). Polyphyllin H downregulates the expression of ABCB1 and ABCC3. Polyphyllin H binds to membrane cholesterol and disrupts lipid raft structures. Polyphyllin H restores the sensitivity of paclitaxel-resistant breast cancer cells to paclitaxel .
    Polyphyllin H
  • HY-N0124R

    Collettiside III (Standard); CCRIS 4123 (Standard)

    Reference Standards Autophagy Apoptosis Cardiovascular Disease Cancer
    Dioscin (Standard) is the analytical standard of Dioscin. This product is intended for research and analytical applications. Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .
    Dioscin (Standard)
  • HY-126941

    ERK MMP Reactive Oxygen Species (ROS) NF-κB p38 MAPK NOD-like Receptor (NLR) TRP Channel TNF Receptor Interleukin Related Infection Neurological Disease Inflammation/Immunology Endocrinology
    Hecogenin acetate is an orally active steroid saponin aglycone with extensive biological activities. Hecogenin acetate inhibits the phosphorylation of NF-κB and p38 MAPK signaling pathways, antagonizes TRPA1/TRPM8 channels, inhibits the production of pro-inflammatory cytokines, and has anti-inflammatory and analgesic effects. Hecogenin acetate inhibits the production of ROS and the activation of NLRP3 inflammasome; downregulates the expression of MMP-2, and has neuroprotective and anti-tumor activities. Hecogenin acetate enhances gastric mucosal defense and promotes ulcer healing. Hecogenin acetate can be used in combination with certain antibiotics to regulate bacterial efflux pumps and restore antibiotic sensitivity .
    Hecogenin acetate
  • HY-N7614
    Anemarrhenasaponin A2
    1 Publications Verification

    Schidigerasaponin F2; Timosaponin AII

    Others Cardiovascular Disease
    Anemarrhenasaponin A2 (Schidigerasaponin F2) is a steroidal saponin isolated from the rhizomes of Anemarrhena asphodeloides. Anemarrhenasaponin A2 inhibits ADP-induced platelet aggregation .
    Anemarrhenasaponin A2
  • HY-N0811

    NO Synthase COX NF-κB MEK Inflammation/Immunology
    Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect .
    Anemarsaponin B
  • HY-N4270

    Others Others
    Pseudoprotogracillin is a steroidal saponin isolated Dioscoreae species .
    Pseudoprotogracillin
  • HY-N13104

    Others Others
    Dracaenoside F is a steroidal saponin that can be isolated from Dracaena cochinchinensis .
    Dracaenoside F
  • HY-N12355

    Others Others
    Disporoside C is a steroidal saponin can be isolated from Disporopsis pernyi .
    Disporoside C
  • HY-N12065

    Others Others
    Parisyunnanoside H is a steroidal saponin isolated from Paris polyphylla Smith var. yunnanensis .
    Parisyunnanoside H
  • HY-N0177R

    Reference Standards STAT MicroRNA Metabolic Disease
    Diosgenin (Standard) is the analytical standard of Diosgenin. This product is intended for research and analytical applications. Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway . Diosgenin is an exogenous activator of Pdia3/ERp57 . Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression .
    Diosgenin (Standard)
  • HY-N11983

    Others Others
    (25R)-Ruscogenin-3-yl α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-glucopyranoside (compound 1) is a steroidal saponin , can be isolated from the roots of Ophiopogon japonicus .
    (25R)-Ruscogenin-3-yl α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-glucopyranoside
  • HY-N3323

    Others Inflammation/Immunology
    Mannioside A is a steroidal saponin. Mannioside A is a nature product that could be isolated from Dracaena mannii. Mannioside A has anti-inflammatory effect .
    Mannioside A
  • HY-N5135R

    Nolinospiroside F (Standard)

    Reference Standards Others Others
    Liriopesides B (Standard) is the analytical standard of Liriopesides B. This product is intended for research and analytical applications. Liriopesides B (Nolinospiroside F) is a steroidal saponin isolated from Ophiopogon japonicas. Liriopesides B has anti-oxidative and anti-aging effects .
    Liriopesides B (Standard)
  • HY-N12128

    Others Cancer
    Ophiopogonin R (compound 3) is a steroid saponin. Ophiopogonin R was isolated and purified from natural ophiopogonin. Ophiopogonin R was not cytotoxic to five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela) .
    Ophiopogonin R
  • HY-N16469

    Ruscoponticoside D; Neoruscine

    Others Cardiovascular Disease Inflammation/Immunology
    Ruscin (Ruscoponticoside D; Neoruscine) is steroidal saponin found in Butcher’s Broom. Ruscin has multiple bioactivities and possesses a variety of pharmacological activities, including anti-inflammatory properties, platelet aggregation inhibition, pulmonary hypertension lowering properties, acute lung injury alleviation .
    Ruscin
  • HY-N12002

    Others Others
    Diosgenin-3-O-rhamnosyl(1→2)[glucosyl(1→6)]glucoside (compound 9) is a steroidal saponin, which can be obtained from Paris polyphylla var., Yunnan pine (yunnanensis) Isolated .
    Diosgenin-3-O-rhamnosyl(1→2)[glucosyl(1→6)]glucoside
  • HY-121593

    Others Others
    Ruizgenin is a new steroidal saponin diol extracted from Agave lecheguilla.
    Ruizgenin
  • HY-133237

    Others Others
    Anemarrhenasaponin III is a steroidal saponin isolated from the rhizome of Anemarrhena asphodeloides Bunge (Liliaceae) .
    Anemarrhenasaponin III
  • HY-N12424

    Others Others
    Elephanoside D (compound 8) is a steroidal saponin isolated from the stems of Yucca elephantipes Regel.
    Elephanoside D
  • HY-N5078

    Others Cardiovascular Disease
    Terrestrosin K, a steroidal saponin from Tribulus terrestris L., has potential to treat cardiovascular and cerebrovascular diseases .
    Terrestrosin K
  • HY-N13137

    Glycosidase Metabolic Disease
    Timosaponin N is a natural steroidal saponin that inhibits the activity of α-Glucosidase. Timosaponin N can be used in diabetes-related research .
    Timosaponin N
  • HY-N3584R

    Chonglou saponin VII (Standard)

    Reference Standards Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis Cancer
    Paris saponin VII (Standard) is the analytical standard of Paris saponin VII. This product is intended for research and analytical applications. Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .
    Paris saponin VII (Standard)
  • HY-16958R

    Antibiotic Dimethylargininase (DDAH) Reference Standards Inflammation/Immunology
    Paris saponin VII (Standard) is the analytical standard of Paris saponin VII. This product is intended for research and analytical applications. Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .
    PD 404182 (Standard)
  • HY-N0706R

    Reference Standards Apoptosis Autophagy Cancer
    Gracillin (Standard) is the analytical standard of Gracillin. This product is intended for research and analytical applications. Gracillin is a steroidal saponin that can be extracted from the roots of the plant and has anti-tumor properties. Gracillin can induce cancer cell apoptosis and autophagy .
    Gracillin (Standard)
  • HY-W046906R

    Reference Standards Endogenous Metabolite Metabolic Disease
    Timosaponin BII (Standard) is the analytical standard of Timosaponin BII. This product is intended for research and analytical applications. Timosaponin BII (Prototimosaponin A III) is a steroid saponin found in the rhizomes of Anemarrhena asphodeloides. Timosaponin BII has neuronal protective, anti-inflammatory and antioxidant activities .
    (E)-Oct-2-enoic acid (Standard)
  • HY-N0799R

    Reference Standards Endogenous Metabolite Cancer
    Protodioscin (Standard) is the analytical standard of Protodioscin. This product is intended for research and analytical applications. Protodioscin, a major steroidal saponin in Trigonella foenum-graecum Linn., has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties.
    Protodioscin (Standard)
  • HY-N0812R

    Prototimosaponin A III (Standard)

    Amyloid-β Reference Standards Neurological Disease Inflammation/Immunology Cancer
    Timosaponin BII (Standard) is the analytical standard of Timosaponin BII. This product is intended for research and analytical applications. Timosaponin BII (Prototimosaponin A III) is a steroid saponin found in the rhizomes of Anemarrhena asphodeloides. Timosaponin BII has neuronal protective, anti-inflammatory and antioxidant activities .
    Timosaponin BII (Standard)
  • HY-N1654

    Bacterial Infection
    2',3'-Dehydrosalannol is a potent antibacterial agent. 2',3'-Dehydrosalannol shows antibacterial activity against K. pneumonia ATCC 13883, P. aeruginosa ATCC 27853, S. aureus ATCC 25922, E. coli ATCC 11775, and E. faecalis ATCC 10541, with MIC values of 0.78, 1.56, 1.56, 6.25, and 25 μg/mL, respectively .
    2',3'-Dehydrosalannol
  • HY-N13136

    Others Cancer
    Timosaponin D, a natural steroid saponin, can be obtained from the rhizome of Anemarrhena asphodeloides. The IC50 values ​​of Timosaponin D against HepG2 and SGC7901 cells are 43.90 and 57.90 μM, respectively. Timosaponin D can be used in anticancer research .
    Timosaponin D
  • HY-N1422R

    Reference Standards Fungal Infection Inflammation/Immunology
    Hecogenin (Standard) is the analytical standard of Hecogenin. This product is intended for research and analytical applications. Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects .
    Hecogenin (Standard)
  • HY-N7576

    Others Cardiovascular Disease
    Anemarrhenasaponin Ia is a steroidal saponin that can be isolated from the rhizomes of Anemarrhena asphodeloides Bunge. Anemarrhenasaponin Ia inhibits platelet aggregation. Anemarrhenasaponin Ia induces mild concentration-dependent hemolysis. Anemarrhenasaponin Ia inhibits fMLP- and AA-induced superoxide anion production, while enhancing PMA-induced superoxide anion production. Anemarrhenasaponin Ia can be used in studies related to thrombosis .
    Anemarrhenasaponin Ia
  • HY-16445BR

    Reference Standards Nucleoside Antimetabolite/Analog Drug Metabolite Apoptosis DNA/RNA Synthesis Cancer
    Dioscin (Standard) is the analytical standard of Dioscin. This product is intended for research and analytical applications. Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .
    CNDAC hydrochloride (Standard)

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