Search Result
Results for "
steroidal saponin
" in MedChemExpress (MCE) Product Catalog:
| Cat. No. |
상품명 |
Target |
연구분야 |
Chemical Structure |
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- HY-N0177
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STAT
MicroRNA
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Metabolic Disease
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Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway . Diosgenin is an exogenous activator of Pdia3/ERp57 . Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression .
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- HY-N0124
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Dioscin
Maximum Cited Publications
11 Publications Verification
Collettiside III; CCRIS 4123
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Autophagy
Apoptosis
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Cardiovascular Disease
Cancer
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Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .
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- HY-N0706
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Apoptosis
Autophagy
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Cancer
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Gracillin is a steroidal saponin that can be extracted from the roots of the plant and has anti-tumor properties. Gracillin can induce cancer cell apoptosis and autophagy .
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- HY-N0799
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Endogenous Metabolite
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Cardiovascular Disease
Cancer
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Protodioscin, a major steroidal saponin in Trigonella foenum-graecum Linn., has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties.
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-
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- HY-N3584
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Chonglou saponin VII
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Akt
p38 MAPK
P-glycoprotein
Bcl-2 Family
Caspase
PARP
Autophagy
Apoptosis
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Cancer
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Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .
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- HY-N8804
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Asparanin B
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Reactive Oxygen Species (ROS)
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Neurological Disease
Cancer
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Shatavarin IV is a steroidal saponin, that can be isolated from the roots of Asparagus racemosus (Liliaceae). Shatavarin IV shows anticancer activity. Shatavarin IV elicits lifespan extension and alleviates Parkinsonism in Caenorhabditis elegans .
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- HY-N1422
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Fungal
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Infection
Inflammation/Immunology
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Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects .
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- HY-N2078
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Neodiosgenin
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LXR
Reactive Oxygen Species (ROS)
Apoptosis
Fatty Acid Synthase (FASN)
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Metabolic Disease
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Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes. Yamogenin is a steroidal saponin that can be obtained from plant species with in vitro cytotoxicity, antioxidant, and antimicrobial properties. Yamogenin induces cell death via the extrinsic and intrinsic way of apoptosis. Yamogenin inhibits protein denaturation with an IC50 of 1421.92 μg/mL. Yamogenin can be studied in research on gastric cancer .
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- HY-N5135
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Nolinospiroside F
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Others
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Others
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Liriopesides B (Nolinospiroside F) is a steroidal saponin isolated from Ophiopogon japonicas. Liriopesides B has anti-oxidative and anti-aging effects .
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- HY-N0863
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NSC-698790; Smilax saponin B
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Bcl-2 Family
Apoptosis
Akt
c-Myc
ERK
p38 MAPK
JNK
FOXO
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Cancer
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Methyl protodioscin (NSC-698790; Smilax saponin B) is a multi-target, selective, steroidal diglycoside inhibitor with antitumor activity that induces cell cycle arrest. The mechanism of action of Methyl protodioscin is complex, involving the induction of G2/M cell cycle arrest, regulation of the Bcl-2/Bax apoptotic pathway, inhibition of the Akt1/c-Myc axis and MAPK/ERK signaling, while simultaneously downregulating ADAM15 and inducing FOXO1 to reduce cholesterol synthesis. It also inhibits the JNK/c-Jun pathway, reducing the production of inflammatory factors (IL-6, TNF-α). Methyl protodioscin exhibits significant antitumor (inhibiting proliferation, migration, invasion, and inducing apoptosis), anti-inflammatory, and anti-restenosis activities. Methyl protodioscin can be used in research on lung cancer, prostate cancer, pancreatic cancer, and other tumors, as well as inflammatory diseases such as airway inflammation and enteritis .
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- HY-107284
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Others
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Others
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Officinalisinin I is a steroidal saponin, isolated from Anemarrhena asphodeloides.
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- HY-N2283
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ERK
Akt
Endogenous Metabolite
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Cancer
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Deltonin, a steroidal saponin, isolated from Dioscorea zingiberensis, has antitumor activity; Deltonin inhibits ERK1/2 and AKT activation.
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- HY-N0812
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- HY-N3504
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Sirtuin
OAT
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Cancer
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Ophiopogonin D' is a steroidal saponin and a SIRT1 activator. Ophiopogonin D' can also regulate the activities of transporters OATP1B1 and OATP1B3. Ophiopogonin D' exhibits certain toxicity to tumor cells. Ophiopogonin D' can be used in tumor research .
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- HY-N6806
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- HY-N2282
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Zingiberensis newsaponin
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Aldose Reductase
JAK
STAT
Autophagy
Apoptosis
NF-κB
SOD
Reactive Oxygen Species (ROS)
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Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
Cancer
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Zingiberen Newsaponin (Zingiberensis newsaponin) is an orally active type of steroid saponin compound. Zingiberen Newsaponin exerts anti-hepatocellular carcinoma (HCC) effects by inhibiting autophagy and the AKR1C1/JAK2/STAT3 pathway. Zingiberen Newsaponin activates oxidative stress (upregulates ROS and MDA) and mitochondrial pathways, promoting cancer cell apoptosis. Zingiberen Newsaponin alleviates cerebral ischemia-reperfusion (I/R) injury by decreasing the concentration of pro-inflammatory cytokines and inhibits NF-κB. Zingiberen Newsaponin can enhance the activity of SOD, eliminate free radicals and protect nerve cells. Zingiberen Newsaponin induces platelet aggregation .
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- HY-N6079
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- HY-N4271
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Others
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Cardiovascular Disease
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Protogracillin is a steroidal furostanol saponin. Protogracillin can be isolated from the rhizomes and tubers of Dioscorea zingiberensis C.H. Wright. Protogracillin is hydrolyzable to Prosapogenin A (HY-N6940). Protogracillin exhibits antithrombotic activity. Protogracillin can be used in research related to cardiovascular diseases .
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- HY-N2382
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Cytochrome P450
P-glycoprotein
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Metabolic Disease
Cancer
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Polyphyllin H is a steroidal saponin. Polyphyllin H is isolated from Paris polyphylla. Polyphyllin H potently inhibits the activities of CYP1A2 (IC50 = 6.44 μM, competitive), CYP2D6 (IC50 = 13.88 μM, competitive) and CYP3A4 (IC50 = 4.52 μM, non-competitive, time-dependent). Polyphyllin H downregulates the expression of ABCB1 and ABCC3. Polyphyllin H binds to membrane cholesterol and disrupts lipid raft structures. Polyphyllin H restores the sensitivity of paclitaxel-resistant breast cancer cells to paclitaxel .
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- HY-N0124R
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Collettiside III (Standard); CCRIS 4123 (Standard)
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Reference Standards
Autophagy
Apoptosis
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Cardiovascular Disease
Cancer
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Dioscin (Standard) is the analytical standard of Dioscin. This product is intended for research and analytical applications. Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .
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- HY-126941
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ERK
MMP
Reactive Oxygen Species (ROS)
NF-κB
p38 MAPK
NOD-like Receptor (NLR)
TRP Channel
TNF Receptor
Interleukin Related
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Infection
Neurological Disease
Inflammation/Immunology
Endocrinology
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Hecogenin acetate is an orally active steroid saponin aglycone with extensive biological activities. Hecogenin acetate inhibits the phosphorylation of NF-κB and p38 MAPK signaling pathways, antagonizes TRPA1/TRPM8 channels, inhibits the production of pro-inflammatory cytokines, and has anti-inflammatory and analgesic effects. Hecogenin acetate inhibits the production of ROS and the activation of NLRP3 inflammasome; downregulates the expression of MMP-2, and has neuroprotective and anti-tumor activities. Hecogenin acetate enhances gastric mucosal defense and promotes ulcer healing. Hecogenin acetate can be used in combination with certain antibiotics to regulate bacterial efflux pumps and restore antibiotic sensitivity .
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- HY-N7614
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Schidigerasaponin F2; Timosaponin AII
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Others
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Cardiovascular Disease
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Anemarrhenasaponin A2 (Schidigerasaponin F2) is a steroidal saponin isolated from the rhizomes of Anemarrhena asphodeloides. Anemarrhenasaponin A2 inhibits ADP-induced platelet aggregation .
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- HY-N0811
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NO Synthase
COX
NF-κB
MEK
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Inflammation/Immunology
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Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect .
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- HY-N4270
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Others
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Others
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Pseudoprotogracillin is a steroidal saponin isolated Dioscoreae species .
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- HY-N13104
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Others
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Others
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Dracaenoside F is a steroidal saponin that can be isolated from Dracaena cochinchinensis .
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- HY-N12355
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Others
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Others
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Disporoside C is a steroidal saponin can be isolated from Disporopsis pernyi .
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- HY-N12065
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Others
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Others
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Parisyunnanoside H is a steroidal saponin isolated from Paris polyphylla Smith var. yunnanensis .
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- HY-N0177R
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Reference Standards
STAT
MicroRNA
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Metabolic Disease
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Diosgenin (Standard) is the analytical standard of Diosgenin. This product is intended for research and analytical applications. Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway . Diosgenin is an exogenous activator of Pdia3/ERp57 . Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression .
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- HY-N11983
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Others
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Others
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(25R)-Ruscogenin-3-yl α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-glucopyranoside (compound 1) is a steroidal saponin , can be isolated from the roots of Ophiopogon japonicus .
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- HY-N3323
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Others
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Inflammation/Immunology
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Mannioside A is a steroidal saponin. Mannioside A is a nature product that could be isolated from Dracaena mannii. Mannioside A has anti-inflammatory effect .
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- HY-N5135R
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Nolinospiroside F (Standard)
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Reference Standards
Others
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Others
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Liriopesides B (Standard) is the analytical standard of Liriopesides B. This product is intended for research and analytical applications. Liriopesides B (Nolinospiroside F) is a steroidal saponin isolated from Ophiopogon japonicas. Liriopesides B has anti-oxidative and anti-aging effects .
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- HY-N12128
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Others
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Cancer
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Ophiopogonin R (compound 3) is a steroid saponin. Ophiopogonin R was isolated and purified from natural ophiopogonin. Ophiopogonin R was not cytotoxic to five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela) .
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- HY-N16469
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Ruscoponticoside D; Neoruscine
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Others
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Cardiovascular Disease
Inflammation/Immunology
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Ruscin (Ruscoponticoside D; Neoruscine) is steroidal saponin found in Butcher’s Broom. Ruscin has multiple bioactivities and possesses a variety of pharmacological activities, including anti-inflammatory properties, platelet aggregation inhibition, pulmonary hypertension lowering properties, acute lung injury alleviation .
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- HY-N12002
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Others
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Others
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Diosgenin-3-O-rhamnosyl(1→2)[glucosyl(1→6)]glucoside (compound 9) is a steroidal saponin, which can be obtained from Paris polyphylla var., Yunnan pine (yunnanensis) Isolated .
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- HY-121593
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Others
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Others
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Ruizgenin is a new steroidal saponin diol extracted from Agave lecheguilla.
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- HY-133237
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Others
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Others
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Anemarrhenasaponin III is a steroidal saponin isolated from the rhizome of Anemarrhena asphodeloides Bunge (Liliaceae) .
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- HY-N12424
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Others
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Others
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Elephanoside D (compound 8) is a steroidal saponin isolated from the stems of Yucca elephantipes Regel.
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- HY-N5078
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Others
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Cardiovascular Disease
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Terrestrosin K, a steroidal saponin from Tribulus terrestris L., has potential to treat cardiovascular and cerebrovascular diseases .
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- HY-N13137
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Glycosidase
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Metabolic Disease
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Timosaponin N is a natural steroidal saponin that inhibits the activity of α-Glucosidase. Timosaponin N can be used in diabetes-related research .
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- HY-N3584R
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Chonglou saponin VII (Standard)
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Reference Standards
Akt
p38 MAPK
P-glycoprotein
Bcl-2 Family
Caspase
PARP
Autophagy
Apoptosis
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Cancer
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Paris saponin VII (Standard) is the analytical standard of Paris saponin VII. This product is intended for research and analytical applications. Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .
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- HY-16958R
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Antibiotic
Dimethylargininase (DDAH)
Reference Standards
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Inflammation/Immunology
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Paris saponin VII (Standard) is the analytical standard of Paris saponin VII. This product is intended for research and analytical applications. Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .
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- HY-N0706R
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Reference Standards
Apoptosis
Autophagy
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Cancer
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Gracillin (Standard) is the analytical standard of Gracillin. This product is intended for research and analytical applications. Gracillin is a steroidal saponin that can be extracted from the roots of the plant and has anti-tumor properties. Gracillin can induce cancer cell apoptosis and autophagy .
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- HY-W046906R
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Reference Standards
Endogenous Metabolite
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Metabolic Disease
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Timosaponin BII (Standard) is the analytical standard of Timosaponin BII. This product is intended for research and analytical applications. Timosaponin BII (Prototimosaponin A III) is a steroid saponin found in the rhizomes of Anemarrhena asphodeloides. Timosaponin BII has neuronal protective, anti-inflammatory and antioxidant activities .
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- HY-N0799R
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Reference Standards
Endogenous Metabolite
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Cancer
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Protodioscin (Standard) is the analytical standard of Protodioscin. This product is intended for research and analytical applications. Protodioscin, a major steroidal saponin in Trigonella foenum-graecum Linn., has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties.
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-
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- HY-N0812R
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Prototimosaponin A III (Standard)
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Amyloid-β
Reference Standards
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Neurological Disease
Inflammation/Immunology
Cancer
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Timosaponin BII (Standard) is the analytical standard of Timosaponin BII. This product is intended for research and analytical applications. Timosaponin BII (Prototimosaponin A III) is a steroid saponin found in the rhizomes of Anemarrhena asphodeloides. Timosaponin BII has neuronal protective, anti-inflammatory and antioxidant activities .
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- HY-N1654
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Bacterial
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Infection
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2',3'-Dehydrosalannol is a potent antibacterial agent. 2',3'-Dehydrosalannol shows antibacterial activity against K. pneumonia ATCC 13883, P. aeruginosa ATCC 27853, S. aureus ATCC 25922, E. coli ATCC 11775, and E. faecalis ATCC 10541, with MIC values of 0.78, 1.56, 1.56, 6.25, and 25 μg/mL, respectively .
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- HY-N13136
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Others
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Cancer
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Timosaponin D, a natural steroid saponin, can be obtained from the rhizome of Anemarrhena asphodeloides. The IC50 values of Timosaponin D against HepG2 and SGC7901 cells are 43.90 and 57.90 μM, respectively. Timosaponin D can be used in anticancer research .
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- HY-N1422R
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Reference Standards
Fungal
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Infection
Inflammation/Immunology
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Hecogenin (Standard) is the analytical standard of Hecogenin. This product is intended for research and analytical applications. Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects .
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- HY-N7576
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Others
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Cardiovascular Disease
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Anemarrhenasaponin Ia is a steroidal saponin that can be isolated from the rhizomes of Anemarrhena asphodeloides Bunge. Anemarrhenasaponin Ia inhibits platelet aggregation. Anemarrhenasaponin Ia induces mild concentration-dependent hemolysis. Anemarrhenasaponin Ia inhibits fMLP- and AA-induced superoxide anion production, while enhancing PMA-induced superoxide anion production. Anemarrhenasaponin Ia can be used in studies related to thrombosis .
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- HY-16445BR
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Reference Standards
Nucleoside Antimetabolite/Analog
Drug Metabolite
Apoptosis
DNA/RNA Synthesis
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Cancer
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Dioscin (Standard) is the analytical standard of Dioscin. This product is intended for research and analytical applications. Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .
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- HY-N18325
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Others
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Others
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Terrestrosin H (Compound 3) is a steroidal saponin that can be isolated from the fruits of Tribulus terrestris .
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- HY-N18045
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- HY-N2078R
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Neodiosgenin (Standard)
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Reference Standards
LXR
Apoptosis
Fatty Acid Synthase (FASN)
Reactive Oxygen Species (ROS)
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Metabolic Disease
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Yamogenin (Standard) is the analytical standard of Yamogenin. This product is intended for research and analytical applications. Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes. Yamogenin is a steroidal saponin that can be obtained from plant species with in vitro cytotoxicity, antioxidant, and antimicrobial properties. Yamogenin induces cell death via the extrinsic and intrinsic way of apoptosis. Yamogenin inhibits protein denaturation with an IC50 of 1421.92 μg/mL. Yamogenin can be studied in research on gastric cancer .
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- HY-N9692
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Others
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Others
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Diosgenyl-3-di-β-O-glucopyranoside (Compound 7a) is a steroidal saponin that can be found in the bulbs of Triteleia lactea .
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- HY-N18255
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Drug Derivative
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Others
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Timosaponin G is a steroidal saponin found in the rhizomes of Anemarrhena asphodeloides .
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- HY-N19427A
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Others
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Others
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Anguivioside XV is a steroidal saponin. Anguivioside XV can be isolated from the fruits of Solanum anguivi .
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- HY-N7964
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- HY-N19118
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Drug Intermediate
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Others
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Ceparoside C is a steroidal saponin found in the seeds of Allium cepa L. Ceparoside C contains a furostanol aglycone (3β,26-dihydroxyfurosta-5,20(22)-diene) and a galactose sugar unit.
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- HY-N19714
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Drug Derivative
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Inflammation/Immunology
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Aspacochinoside N is a pregnane glycoside (steroidal saponin) found in the roots of Asparagus cochinchinensis with an IC50 > 100 μM for NO production inhibition. Aspacochinoside N can be used in research on neuroinflammation .
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- HY-N19080
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Bacterial
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Infection
Inflammation/Immunology
Cancer
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Smilax glabra extract possesses a variety of benefits, including anti-inflammatory, antioxidant, antibacterial, and anticancer properties. It contains numerous active ingredients, such as dihydroflavonol glycosides (e.g., asstebin and neo-asstebin), flavonol glycosides, and steroidal saponins, including smilax saponin.
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- HY-N16989
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Others
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Others
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Neochlorogenin is a spirostan-type steroidal saponin aglycone that can be naturally extracted from the dried leaves of Solanum torvum Sw. (Indian nightshade) .
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- HY-N7920
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Others
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Cancer
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Protobioside is a steroidal saponin found in the dry bulbs of Fritillaria pallidiflora Schrenk. Protobioside shows no significant cytotoxic activity against human cancer cells .
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- HY-N18755
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- HY-N17760
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Fungal
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Others
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(25RS)-Schidigera-saponin E1 is a steroidal saponin with anti-yeast activity, which can be isolated from the stems of Yucca schidigera (Mojave yucca). (25RS)-Schidigera-saponin E1 exerts weak anti-yeast activity by affecting the integrity of microbial cell membranes, with a MIC≥100 μg/mL against some food spoilage yeasts. (25RS)-Schidigera-saponin E1 can be used in the field of food preservation to extend the shelf life of foods containing cooked rice, beans, fermented condiments, etc.
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- HY-N19055
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Others
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Inflammation/Immunology
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Asparagus racemosus extract, derived from the roots of Asparagus racemosus (also known as Satavali), contains bioactive components such as saponins, steroidal glycosides, polyphenols, vitamins, flavonoids, and alkaloids. Asparagus racemosus extract is renowned for its anti-inflammatory and immunomodulatory properties.
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- HY-N18376
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Drug Derivative
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Cancer
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25(S)-Ruscogenin-1-O-β-D-xylopyranoside-3-O-α-L-rhamnopyranoside is a steroidal saponin with antitumor effects. 25(S)-Ruscogenin-1-O-β-D-xylopyranoside-3-O-α-L-rhamnopyranoside shows an IC50 value of 13.3 μg/mL against human cervical carcinoma cells. 25(S)-Ruscogenin-1-O-β-D-xylopyranoside-3-O-α-L-rhamnopyranoside can be used for the research of cervical carcinoma .
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| Cat. No. |
상품명 |
Category |
Target |
Chemical Structure |
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- HY-N0177
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- HY-N0124
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- HY-N0706
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- HY-N0799
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- HY-N3584
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- HY-N8804
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- HY-N1422
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- HY-N2078
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- HY-N5135
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- HY-N0863
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NSC-698790; Smilax saponin B
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Structural Classification
other families
Classification of Application Fields
Plants
Disease Research Fields
Steroids
Source Classification
Cancer
|
Bcl-2 Family
Apoptosis
Akt
c-Myc
ERK
p38 MAPK
JNK
FOXO
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Methyl protodioscin (NSC-698790; Smilax saponin B) is a multi-target, selective, steroidal diglycoside inhibitor with antitumor activity that induces cell cycle arrest. The mechanism of action of Methyl protodioscin is complex, involving the induction of G2/M cell cycle arrest, regulation of the Bcl-2/Bax apoptotic pathway, inhibition of the Akt1/c-Myc axis and MAPK/ERK signaling, while simultaneously downregulating ADAM15 and inducing FOXO1 to reduce cholesterol synthesis. It also inhibits the JNK/c-Jun pathway, reducing the production of inflammatory factors (IL-6, TNF-α). Methyl protodioscin exhibits significant antitumor (inhibiting proliferation, migration, invasion, and inducing apoptosis), anti-inflammatory, and anti-restenosis activities. Methyl protodioscin can be used in research on lung cancer, prostate cancer, pancreatic cancer, and other tumors, as well as inflammatory diseases such as airway inflammation and enteritis .
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- HY-107284
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- HY-N2283
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- HY-N0812
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- HY-N3504
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- HY-N6806
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- HY-N2282
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- HY-N6079
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- HY-N4271
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- HY-N2382
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Structural Classification
other families
Plants
Steroids
Source Classification
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Cytochrome P450
P-glycoprotein
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Polyphyllin H is a steroidal saponin. Polyphyllin H is isolated from Paris polyphylla. Polyphyllin H potently inhibits the activities of CYP1A2 (IC50 = 6.44 μM, competitive), CYP2D6 (IC50 = 13.88 μM, competitive) and CYP3A4 (IC50 = 4.52 μM, non-competitive, time-dependent). Polyphyllin H downregulates the expression of ABCB1 and ABCC3. Polyphyllin H binds to membrane cholesterol and disrupts lipid raft structures. Polyphyllin H restores the sensitivity of paclitaxel-resistant breast cancer cells to paclitaxel .
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- HY-N0124R
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Collettiside III (Standard); CCRIS 4123 (Standard)
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Structural Classification
other families
Plants
Steroids
Source Classification
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Reference Standards
Autophagy
Apoptosis
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Dioscin (Standard) is the analytical standard of Dioscin. This product is intended for research and analytical applications. Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .
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- HY-126941
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- HY-N7614
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- HY-N0811
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- HY-N4270
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- HY-N13104
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- HY-N12355
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- HY-N12065
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- HY-N0177R
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- HY-N11983
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- HY-N3323
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- HY-N5135R
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- HY-N12128
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- HY-N16469
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- HY-N12002
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- HY-133237
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- HY-N12424
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- HY-N5078
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- HY-N13137
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- HY-N3584R
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Chonglou saponin VII (Standard)
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Structural Classification
Liliaceae
Trillium tschonoskii Maxim.
Plants
Steroids
Source Classification
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Reference Standards
Akt
p38 MAPK
P-glycoprotein
Bcl-2 Family
Caspase
PARP
Autophagy
Apoptosis
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Paris saponin VII (Standard) is the analytical standard of Paris saponin VII. This product is intended for research and analytical applications. Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .
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- HY-N0706R
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- HY-W046906R
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- HY-N0799R
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- HY-N0812R
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- HY-N1654
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Infection
Natural Products
Classification of Application Fields
Azadirachta indica A. Juss.
Plants
Meliaceae
Disease Research Fields
Source Classification
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Bacterial
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2',3'-Dehydrosalannol is a potent antibacterial agent. 2',3'-Dehydrosalannol shows antibacterial activity against K. pneumonia ATCC 13883, P. aeruginosa ATCC 27853, S. aureus ATCC 25922, E. coli ATCC 11775, and E. faecalis ATCC 10541, with MIC values of 0.78, 1.56, 1.56, 6.25, and 25 μg/mL, respectively .
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- HY-N13136
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- HY-N1422R
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- HY-N7576
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- HY-N18325
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- HY-N18045
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-
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- HY-N2078R
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Neodiosgenin (Standard)
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Structural Classification
other families
Plants
Steroids
Source Classification
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Reference Standards
LXR
Apoptosis
Fatty Acid Synthase (FASN)
Reactive Oxygen Species (ROS)
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Yamogenin (Standard) is the analytical standard of Yamogenin. This product is intended for research and analytical applications. Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes. Yamogenin is a steroidal saponin that can be obtained from plant species with in vitro cytotoxicity, antioxidant, and antimicrobial properties. Yamogenin induces cell death via the extrinsic and intrinsic way of apoptosis. Yamogenin inhibits protein denaturation with an IC50 of 1421.92 μg/mL. Yamogenin can be studied in research on gastric cancer .
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- HY-N9692
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- HY-N18255
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- HY-N19427A
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- HY-N7964
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- HY-N19118
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- HY-N19714
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- HY-N19080
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Structural Classification
Extract
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Bacterial
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Smilax glabra extract possesses a variety of benefits, including anti-inflammatory, antioxidant, antibacterial, and anticancer properties. It contains numerous active ingredients, such as dihydroflavonol glycosides (e.g., asstebin and neo-asstebin), flavonol glycosides, and steroidal saponins, including smilax saponin.
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- HY-N16989
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- HY-N7920
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- HY-N18755
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Structural Classification
Extract
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Bacterial
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Solanum xanthocarpum extract possesses anti-inflammatory, analgesic, antibacterial, and antiviral properties, and is rich in various bioactive compounds, such as alkaloids, triterpenoids, saponins, steroidal glycoalkaloids, and flavonoids.
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- HY-N17760
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- HY-N19055
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Structural Classification
Extract
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Others
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Asparagus racemosus extract, derived from the roots of Asparagus racemosus (also known as Satavali), contains bioactive components such as saponins, steroidal glycosides, polyphenols, vitamins, flavonoids, and alkaloids. Asparagus racemosus extract is renowned for its anti-inflammatory and immunomodulatory properties.
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- HY-N18376
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