68422-00-4
Chemical Structure
Timosaponin A1
- CAS No.: 68422-00-4
- Formula:C33H54O8
- Molecular Weight:578.78
IUPAC Name: (2R,3R,4S,5R,6R)-2-(hydroxymethyl)-6-(((2aR,4S,5'S,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bR)-5',6a,8a,9-tetramethyldocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy)tetrahydro-2H-pyran-3,4,5-triol
InChIKey: ZNEIIZNXGCIAAL-MYNIFUFOSA-N
SMILES: C[C@@]12[C@]3([H])[C@](O[C@]4(CC[C@H](C)CO4)[C@H]3C)([H])C[C@@]1([H])[C@@]5([H])[C@]([C@@]6([C@](C[C@@H](O[C@]7([H])O[C@@H]([C@H](O)[C@H](O)[C@H]7O)CO)CC6)([H])CC5)C)([H])CC2
Biological Activity: Timosaponin A1, a natural steroidal saponin, is a 5-lipoxygenase (5-LO), COX-2, and dipeptidyl peptidase 4 (DPP-4) inhibitor with IC50s of 3.29 µM, 36.43 µM, and 33.25 µM, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Timosaponin A1 | 99.70% | Timosaponin A1, a natural steroidal saponin, is a 5-lipoxygenase (5-LO), COX-2, and dipeptidyl peptidase 4 (DPP-4) inhibitor with IC50s of 3.29 µM, 36.43 µM, and 33.25 µM, respectively. | ||||||||||||||||||||
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- [1]. Linlin Xie, et al. Characterization of spirostanol glycosides and furostanol glycosides from anemarrhenae rhizoma as dual targeted inhibitors of 5-lipoxygenase and Cyclooxygenase-2 by employing a combination of affinity ultrafiltration and HPLC/MS. Phytomedicine. 2020 Oct:77:153284. [Content Brief]
- [2]. Shumin Jiang, et al. The potential DPP-4 inhibitors from Xiao-Ke-An improve the glucolipid metabolism via the activation of AKT/GSK-3β pathway. Eur J Pharmacol. 2020 Sep 5:882:173272. [Content Brief]
Keywords
