170 Results for "

tyrosine kinase 2

" in MedChemExpress (MCE) Product Catalog:
Products (170)

170 Results for "tyrosine kinase 2" in MCE Product Catalog:

36
36 Publications Verification
Cat. No.: HY-117287
CAS No.: 1609392-27-9
Purity:  99.87%
Synonyms: BMS-986165
Deucravacitinib (BMS-986165) is an orally active allosteric inhibitor of tyrosine kinase 2 (TYK2), with an IC50 of 0.2 nM and a Ki of 0.02 nM against the JH2 domain of TYK2, and it exhibits selectivity over other JAK subtypes and most of the kinome. Deucravacitinib blocks IL-23, IL-12, p-STAT1/3 and Type I IFN signaling, and inhibits Th17/Th1-mediated psoriasis inflammation . Deucravacitinib can be used in research related to moderate-to-severe plaque psoriasis, inflammatory bowel disease and systemic lupus erythematosus .
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6
6 Cited Publications
Cat. No.: HY-10460
CAS No.: 717906-29-1
Purity:  99.74%
Target:  

Pyk2 FAK

Research Areas:  

Cancer

PF-431396 is an orally active dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor, with IC50 values of 2 nM and 11 nM, respectively .
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4
4 Cited Publications
Cat. No.: HY-P80727
Synonyms: JAK2; tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2

Host:  

Rabbit

Application:  

WB

Reactivity:  

Human, Mouse

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3
3 Cited Publications
Cat. No.: HY-P7989
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: JAK2; JAK-2; Janus kinase 2; Janus kinase 2 (A Protein tyrosine kinase); JTK10; tyrosine-Protein kinase; tyrosine-Protein kinase JAK2; Janus kinase
Species:  
Human
Source:  
E. coli
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2
2 Cited Publications
Cat. No.: HY-P70178
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FLT3; CD135 Antigen; Fms Related Receptor tyrosine kinase 3; FLK-2; CD135; Growth Factor Receptor tyrosine kinase Type III; STK1; Receptor Protein-tyrosine kinase; FLK2; Fms-Related tyrosine kinase 3; Fms-Like tyrosine kinase 3; Fetal Liver kinase 2; Rece
Species:  
Human
Source:  
HEK293
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2
2 Cited Publications
Cat. No.: HY-13455
CAS No.: 184582-62-5
Purity:  99.58%
Target:  

Haspin Kinase DYRK

Research Areas:  

Cancer

LDN-192960 is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively .
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2
2 Cited Publications
Cat. No.: HY-13455A
CAS No.: 2309172-48-1
Purity:  99.78%
Target:  

Haspin Kinase DYRK

Research Areas:  

Cancer

LDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively .
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2
2 Cited Publications
Cat. No.: HY-111745
CAS No.: 1797432-62-2
Purity:  99.35%
Target:  

JAK

Research Areas:  

Inflammation/Immunology

Tyk2-IN-5 (compound 6) is a potent, selective and orally active tyrosine kinase 2 (Tyk2) inhibitor that acts on the JH2 structural domain. Tyk2-IN-5 shows a Ki value of 0.086 nM for Tyk2 JH2 and an IC50 value of 25 nM for IFNα. Tyk2-IN-5 efficiently inhibits the production of IFNγ in a pharmacodynamic rat model and is fully efficacious in a rat model of arthritis .
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2
2 Cited Publications
Cat. No.: HY-P73094
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ERBB2; P185erbB2; Prev. NGL; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 (Neuro/Glioblastoma Derived Oncogene Homolog); HER2; V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog; NEU; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2 Isoform C; Receptor tyrosine-Protein kinase ErbB-2; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2; Proto-Oncogene C-ErbB-2; Neuroblastoma/Glioblastoma Derived Oncogene Homolog; Proto-Oncogene Neu; Receptor tyrosine-Protein kinase ErbB-2 Variant; P185(ErbB2); Truncated HER2 Splice Variant P100; C-ERB-2; Receptor Protein-tyrosine kinase; C-ERB2; Metastatic Lymph Node Gene 19; MLN-19; Alternative Protein ERBB2; HER-2; C-Erb B2/Neu Protein; CD340; CD340 Antigen; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2; HER-2/Neu; tyrosine kinase-Type Cell Surface Receptor HER2; Herstatin; Neuro/Glioblastoma Derived Oncogene Homolog; VSCN2; Human Epidermal Growth Factor Receptor 2; MLN19; Metastatic Lymph Node Gene 19 Protein; TKR1; Erb-B2 Receptor tyrosine kinase 2; MLN 19
Species:  
Human
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P701102
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: JAK2; JAK-2; Janus kinase 2; Janus kinase 2 (A Protein tyrosine kinase); JTK10; tyrosine-Protein kinase; tyrosine-Protein kinase JAK2; Janus kinase
Species:  
Human
Source:  
E. coli
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1
1 Cited Publications
Cat. No.: HY-P75748
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: EPHB1; ELK; Prev. EPHT2; EK6; Hek6; Receptor Protein-tyrosine kinase; Neuronally-Expressed EPH-Related tyrosine kinase; Eph tyrosine kinase 2; tyrosine-Protein kinase Receptor EPH-2; EPH tyrosine kinase 2; Ephrin Type-B Receptor 1; EphB1; EPH-Like kinase
Species:  
Mouse
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P80829A
Synonyms: JAK2; tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IP, FC

Reactivity:  

Human, Mouse, Rat

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1
1 Cited Publications
Cat. No.: HY-P75223
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MAPK1; MAPK 2; Prev. PRKM1; ERT1; Prev. PRKM2; Mitogen-Activated Protein kinase; ERK2; Protein tyrosine kinase ERK2; Extracellular Signal-Regulated kinase 2; MAP kinase Isoform P42; P41mapk; P42MAPK; MAPK2; MAPK 1; ERK; NS13; Mitogen-Activated Protein Kin
Species:  
Human
Source:  
Sf9 insect cells
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1
1 Cited Publications
Cat. No.: HY-P80467
Synonyms: tyrosine-protein kinase JAK2, Janus kinase 2, JAK-2, JAK2

Host:  

Rabbit

Application:  

WB, ICC/IF, IHC-P, IP

Reactivity:  

Human, Mouse, Rat

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1
1 Cited Publications
Cat. No.: HY-P80460
Synonyms: FAK, FAK1, PTK2, Focal adhesion kinase 1, FADK 1, Focal adhesion kinase-related nonkinase, Protein phosphatase 1 regulatory subunit 71, Protein-tyrosine kinase 2, p125FAK, pp125FAK, FRNK, PPP1R71

Host:  

Rabbit

Application:  

WB, ICC/IF

Reactivity:  

Human, Mouse

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Cat. No.: HY-P701672
Purity:  ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: DYRK2; Dual Specificity tyrosine-Phosphorylation-Regulated kinase 2; Dual Specificity tyrosine Phosphorylation Regulated kinase 2; Dual-Specificity tyrosine-(Y)-Phosphorylation Regulated kinase 2; Dual Specificity tyrosine-(Y)-Phosphorylation Regulated Ki
Species:  
Human
Source:  
E. coli
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Cat. No.: HY-P706035
Purity:  ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: DYRK2; Dual Specificity tyrosine-Phosphorylation-Regulated kinase 2; Dual Specificity tyrosine Phosphorylation Regulated kinase 2; Dual-Specificity tyrosine-(Y)-Phosphorylation Regulated kinase 2; Dual Specificity tyrosine-(Y)-Phosphorylation Regulated Ki
Species:  
Human
Source:  
Sf9 insect cells
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Cat. No.: HY-P704597
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: JAK2; JAK-2; Janus kinase 2; Janus kinase 2 (A Protein tyrosine kinase); JTK10; tyrosine-Protein kinase; tyrosine-Protein kinase JAK2; Janus kinase
Species:  
Human
Source:  
Sf9 insect cells
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Cat. No.: HY-P83132
Synonyms: EPHB3; ETK2; HEK2; TYRO6; Ephrin type-B receptor 3; EPH-like tyrosine kinase 2; EPH-like kinase 2; Embryonic kinase 2; EK2; hEK2; tyrosine-protein kinase TYRO6

Host:  

Rabbit

Application:  

WB, ICC/IF

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P85147
Synonyms: EPHB3; ETK2; HEK2; TYRO6; Ephrin type-B receptor 3; EPH-like tyrosine kinase 2; EPH-like kinase 2; Embryonic kinase 2; EK2; hEK2; tyrosine-protein kinase TYRO6

Host:  

Mouse

Application:  

WB, IHC-P, ICC/IF, ELISA

Reactivity:  

Human

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