Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
zinc-finger protein degradation
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "zinc-finger protein degradation" in MCE Product Catalog:
Cat. No.: HY-160695
CAS No.: 2924858-25-1
Target:
Research Areas:
PT-179 is an orthogonal Thalidomide (HY-14658) derivative that targets cereblon without causing off-target degradation effects. PT-179 is able to specifically bind CRBN, form a ternary complex with a target protein fused to a zinc finger (ZF) degron, and mediate the degradation of the tagged protein. For example, PT-179 binds to the ubiquitin ligase substrate receptor cereblon by forming a complex with SD40 and efficiently degrades proteins N- or C-terminally fused to SD40 or SD36 (DC50 for eGFP: 4.5 nM and 14.3 nM). PT-179 can be used to develop compact protein degradation tagging platforms .
Cat. No.: HY-178683
CAS No.: 2438125-72-3
ALV-05-077-01 is a BCL6/BCL6B degrader. ALV-05-077-01 binds to CRBN and recruits specific zinc finger proteins as neo-substrates for ubiquitination and proteasomal degradation. ALV-05-077-01 induces the degradation of full-length endogenous BCL6 zinc finger protein. ALV-05-077-01 induces the degradation of full-length endogenous BCL6B zinc finger protein. ALV-05-077-01 can be used in the research of hematological malignancies .
Cat. No.: HY-178700
CAS No.: 2744249-11-2
ALV-05-151-02 is a BCL6B zinc finger protein degrader that selectively targets BCL6B over BCL6. ALV-05-151-02 redirects the E3 ubiquitin ligase CRL4CRBN to induce BCL6B degradation and interacts with the H357 residue of BCL6B .
Cat. No.: HY-182467A
Research Areas:
BMS-986482 acetate is a CRBN-mediated IKZF1-4 (Ikaros family zinc finger 1-4) molecular glue degrader. BMS-986482 acetate's activity is driven by a non-traditional CELMoD core that selectively degrades the IKZF protein family. BMS-986482 acetate can be used for the research of advanced solid tumors .
Cat. No.: HY-182467
CAS No.: 3062993-48-7
Research Areas:
BMS-986482 is a CRBN-mediated IKZF1-4 (Ikaros family zinc finger 1-4) molecular glue degrader. BMS-986482's activity is driven by a non-traditional CELMoD core that selectively degrades the IKZF protein family. BMS-986482 can be used for the research of advanced solid tumors .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
