SJF-1521

Cat. No.: HY-131865 Purity: 99.65%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

SJF-1521 is a selective EGFR PROTAC degrader. SJF-1521 is capable of inducing EGFR degradation in OVCAR8 cells. SJF-1521 can be used for tumor research.
(Pink: EGFR ligand (HY-177379); Blue: VHL ligand (HY-125845); Black: linker (HY-128804)).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

SJF-1521 화학구조

CAS No. : 2230821-40-4

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

View All PROTACs Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

Biological Activity
순도&문서
References
고객리뷰

제품 설명

SJF-1521 is a selective EGFR PROTAC degrader. SJF-1521 is capable of inducing EGFR degradation in OVCAR8 cells. SJF-1521 can be used for tumor research^[1]. (Pink: EGFR ligand (HY-177379); Blue: VHL ligand (HY-125845); Black: linker (HY-128804)).

IC₅₀ & Target^[1]

VHL

In Vitro

SJF-1521 (25 nM-10 μM; 24 h) selectively degrades EGFR in OVCAR8 cells, while it has no effect on HER2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	OVCAR8 cells
Concentration:	25 nM, 100 nM, 250 nM, 1 μM, 2.5 μM, 10 μM
Incubation Time:	24 h
Result:	Significantly reduced the levels of EGFR, and did not affect the levels of HER2.

분자량

1074.65

화학식

C₅₇H₆₁ClFN₇O₉S

CAS No.

2230821-40-4

Appearance

Solid

Color

Light green to yellow

SMILES

O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCOCCOCCOC(C=C4)=CC=C4C5=CC(C(NC6=CC(Cl)=C(C=C6)OCC7=CC(F)=CC=C7)=NC=N8)=C8C=C5)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : ≥ 200 mg/mL (186.11 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9305 mL	4.6527 mL	9.3054 mL
5 mM	0.1861 mL	0.9305 mL	1.8611 mL
10 mM	0.0931 mL	0.4653 mL	0.9305 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.65%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (249 KB) HNMR (344 KB) RP-HPLC (250 KB) MS (69 KB) Elemental Analysis Report (106 KB)

Handling Instructions (2659 KB)

References

[1]. Burslem GM,et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.9305 mL	4.6527 mL	9.3054 mL	23.2634 mL
	5 mM	0.1861 mL	0.9305 mL	1.8611 mL	4.6527 mL
	10 mM	0.0931 mL	0.4653 mL	0.9305 mL	2.3263 mL
	15 mM	0.0620 mL	0.3102 mL	0.6204 mL	1.5509 mL
	20 mM	0.0465 mL	0.2326 mL	0.4653 mL	1.1632 mL
	25 mM	0.0372 mL	0.1861 mL	0.3722 mL	0.9305 mL
	30 mM	0.0310 mL	0.1551 mL	0.3102 mL	0.7754 mL
	40 mM	0.0233 mL	0.1163 mL	0.2326 mL	0.5816 mL
	50 mM	0.0186 mL	0.0931 mL	0.1861 mL	0.4653 mL
	60 mM	0.0155 mL	0.0775 mL	0.1551 mL	0.3877 mL
	80 mM	0.0116 mL	0.0582 mL	0.1163 mL	0.2908 mL
	100 mM	0.0093 mL	0.0465 mL	0.0931 mL	0.2326 mL

SJF-1521 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJF-15212230821-40-4SJF1521SJF 1521EGFRPROTACsEpidermal growth factor receptorErbB-1HER1PROTACTargeted DegradationReceptor Tyrosine KinasesHER2c-MetVHLOVCAR8 cellsInhibitorinhibitorinhibit

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