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Cat. No.: HY-184739

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SMP-70067-L

SMP-70067-L (DL10) is a conjugate of a toxic molecule and a linker, in which the toxin moiety is Exatecan (HY-13631) and the linker moiety is SMP-93566-4-Leu-Cit-PAB-Glu (Ac) (HY-184740). SMP-70067-L can be used to synthesize the ADC SMP-70067-X.

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CAS No.: 3120799-14-3
Formule: C₆₇H₈₂FN₁₃O₁₉
Masse moléculaire:1392.44

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SMP-70067-L Chemical Structure

CAS No.: 3120799-14-3

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Drug-Linker Conjugates for ADC :

In Vitro

The drug-linker conjugates of antibody-drug conjugates (ADCs) consist of active cytotoxic drugs and appropriate linkers. After conjugation with monoclonal antibodies, these conjugates can be used to prepare ADCs, which are highly selective and cytotoxic targeted drugs against cancer cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

CAS No. 3120799-14-3
Masse moléculaire 1392.44
Formule C₆₇H₈₂FN₁₃O₁₉
SMILES

CC[C@]1(C(OCC2=C1C=C3C4=NC5=CC(F)=C(C6=C5C([C@H](CC6)NC(OCC7=CC=C(C=C7NC([C@@H](NC(C)=O)CCC(O)=O)=O)NC([C@@H](NC([C@H](C(C)C)NC(CN8CCOCCN(CCOCC8)C(CCN9C(C=CC9=O)=O)=O)=O)=O)CCCNC(N)=O)=O)=O)=C4CN3C2=O)C)=O)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Heng X, et al. An intrinsically hydrophilic linker enables a stable, high-DAR exatecan-based HER2 ADC with potent antitumor activity. European journal of medicinal chemistry. 2026 Oct 15;316:119054. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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