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Cat. No.: HY-137629

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Sp-8-pCPT-PET-cGMPS

Sp-8-pCPT-PET-cGMPS is an activator for PKG-I. Sp-8-pCPT-PET-cGMPS can be used for research of NO/NOS/sGC/PKG-I signaling pathway in cardiac differentiation.

For research use only. We do not sell to patients.

CAS No.: 1262749-63-2
Formula: C₂₄H₁₉ClN₅O₆PS₂
Molecular Weight:603.99

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Sp-8-pCPT-PET-cGMPS Chemical Structure

CAS No.: 1262749-63-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Sp-8-pCPT-PET-cGMPS is an activator for PKG-I. Sp-8-pCPT-PET-cGMPS can be used for research of NO/NOS/sGC/PKG-I signaling pathway in cardiac differentiation^[1].

Chemical Information

CAS No. 1262749-63-2
Molecular Weight 603.99
Formula C₂₄H₁₉ClN₅O₆PS₂
SMILES

O=C(N(C=C(C1=CC=CC=C1)N2)C2=N3)C4=C3N(C(SC5=CC=C(Cl)C=C5)=N4)[C@@H]6O[C@H](CO[P@@]7(S)=O)[C@@H](O7)[C@H]6O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Human pluripotent stem cell cardiomyocyte differentiation
Human pluripotent stem cell cardiomyocyte differentiation is commonly driven by timed modulation of developmental signaling: early Wnt/β-catenin activation through GSK3 inhibition promotes mesoderm induction, and subsequent Wnt inhibition promotes cardiac specification; this principle was demonstrated in defined, growth-factor-free monolayer systems that generated functional cardiomyocytes from multiple hPSC lines. The experimental readout is the emergence of cardiomyocyte identity and function, measured by spontaneous contraction, immunostaining or flow cytometry for cardiac proteins such as cTnT, α-actinin, MLC2a, or sarcomeric myosin, and functional assays such as electrophysiology or calcium/action-potential responses when required.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Spinelli V, et al., Role of Nitric Oxide, Nitric Oxide Synthase, Soluble Guanylyl Cyclase, and cGMP-Dependent Protein Kinase I in Mouse Stem Cell Cardiac Development. Stem Cells Int. 2016;2016:2868323. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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