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Cat. No.: HY-187730

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STOCK3S-30866

STOCK3S-30866 is a blood-brain barrier-permeable ligand of human serotonin transporter (hSERT) and leucine transporter (LeuT). STOCK3S-30866 has gastrointestinal absorption capacity and no mutagenic potential. STOCK3S-30866 can be used in research related to major depressive disorder.

For research use only. We do not sell to patients.

CAS No.: 684238-05-9
Formula: C₂₈H₂₃FN₄O₂S
Molecular Weight:498.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

STOCK3S-30866 Chemical Structure

CAS No.: 684238-05-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

STOCK3S-30866 meets Lipinski's Rule of Five, exhibits high human intestinal absorption, and has favorable pharmacokinetic and non-mutagenic toxicological profiles, with predicted hepatotoxicity and hERG II inhibition requiring experimental validation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 684238-05-9
Molecular Weight 498.58
Formula C₂₈H₂₃FN₄O₂S
SMILES

N#CC1=C(SCC(=O)NC2=CC=C3C(=C2)C=4C=CC=CC4N3CC)NC(=O)CC1C=5C=CC=CC5F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Genotoxicity/Mutagenicity Study
The bacterial reverse mutation assay detects point mutations that restore amino-acid prototrophy in auxotrophic Salmonella typhimurium or Escherichia coli tester strains; after exposure to a test article, mutagenic activity is read out as an increased number of revertant colonies on minimal agar compared with the vehicle control. The assay uses tester strains with different mutation targets so that base-substitution and frameshift mutagens can be detected, and testing is performed with and without exogenous mammalian metabolic activation because some chemicals require biotransformation to become mutagenic.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ayipo YO, et al. Carbazole derivatives as promising competitive and allosteric inhibitors of human serotonin transporter: computational pharmacology. Journal of biomolecular structure & dynamics. 2024;42(2):993-1014.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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