TAK-637
TAK-637 is an orally active neurokinin-1 receptor antagonist. TAK-637 increases bladder storage capacity. TAK-637 can be used for research of functional bowel diseases such as irritable bowel syndrome.
For research use only. We do not sell to patients.
- CAS No.: 217185-75-6
- Formula: C30H25F6N3O2
- Molecular Weight:573.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| IM-9 | IC50 |
0.45 nM
Compound: 19, TAK-637
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Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
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[PMID: 21807525] |
Chemical Information
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CAS No. 217185-75-6
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Molecular Weight 573.53
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Formula C30H25F6N3O2
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SMILES
O=C1C2=C(C(C3=CC=C(C)C=C3)=C4C(N(CC(CCN14)C)CC5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=O)C=CC=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Okano S, et al. Effects of TAK-637, a novel neurokinin-1 receptor antagonist, on colonic function in vivo. J Pharmacol Exp Ther. 2001 Aug;298(2):559-64. [Content Brief]
[2]. Kamo I, Doi T. Effect of TAK-637, a tachykinin NK1-receptor antagonist, on lower urinary tract function in cats. Jpn J Pharmacol. 2001 Jun;86(2):165-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TAK-637 Related Classifications
HY-105534 Related Classifications
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