217185-75-6
217185-75-6
Chemical Structure
TAK-637
- CAS No.: 217185-75-6
- Formula:C30H25F6N3O2
- Molecular Weight:573.53
IUPAC Name: 7-(3,5-bis(trifluoromethyl)benzyl)-9-methyl-5-(p-tolyl)-8,9,10,11-tetrahydro-7H-[1,4]diazocino[2,1-g][1,7]naphthyridine-6,13-dione
InChIKey: LDXQLWNPGRANTO-UHFFFAOYSA-N
SMILES: O=C1C2=C(C(C3=CC=C(C)C=C3)=C4C(N(CC(CCN14)C)CC5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=O)C=CC=N2
Biological Activity: TAK-637 is an orally active neurokinin-1 receptor antagonist. TAK-637 increases bladder storage capacity. TAK-637 can be used for research of functional bowel diseases such as irritable bowel syndrome[1][2].
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TAK-637 | TAK-637 is an orally active neurokinin-1 receptor antagonist. TAK-637 increases bladder storage capacity. TAK-637 can be used for research of functional bowel diseases such as irritable bowel syndrome. | |||||||||||||||||||||
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References
- [1]. Okano S, et al. Effects of TAK-637, a novel neurokinin-1 receptor antagonist, on colonic function in vivo. J Pharmacol Exp Ther. 2001 Aug;298(2):559-64. [Content Brief]
- [2]. Kamo I, Doi T. Effect of TAK-637, a tachykinin NK1-receptor antagonist, on lower urinary tract function in cats. Jpn J Pharmacol. 2001 Jun;86(2):165-9. [Content Brief]
Keywords
