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Cat. No.: HY-163137

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Telomerase-IN-6

Telomerase-IN-6（6f）is a telomerase inhibitor with antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 3032480-07-9
Formula: C₁₈H₁₂ClN₅O₂S
Molecular Weight:397.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Telomerase-IN-6 Chemical Structure

CAS No.: 3032480-07-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Telomerase-IN-6（6f）is a telomerase inhibitor with antitumor activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	87 μM Compound: 6f	Cytotoxicity against human A549 cells overexpressing telomerase assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Cytotoxicity against human A549 cells overexpressing telomerase assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38117230]
HepG2	IC₅₀	33 μM Compound: 6f	Cytotoxicity against human HepG2 cells overexpressing telomerase assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Cytotoxicity against human HepG2 cells overexpressing telomerase assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38117230]
Huh-7	IC₅₀	33 μM Compound: 6f	Cytotoxicity against human Huh-7 cells overexpressing telomerase assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Cytotoxicity against human Huh-7 cells overexpressing telomerase assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38117230]
NCI-H1299	IC₅₀	32 μM Compound: 6f	Cytotoxicity against human NCI-H1299 cells overexpressing telomerase assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Cytotoxicity against human NCI-H1299 cells overexpressing telomerase assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38117230]
NCI-H460	IC₅₀	48 μM Compound: 6f	Cytotoxicity against human NCI-H460 cells overexpressing telomerase assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Cytotoxicity against human NCI-H460 cells overexpressing telomerase assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38117230]

Chemical Information

CAS No. 3032480-07-9
Molecular Weight 397.84
Formula C₁₈H₁₂ClN₅O₂S
SMILES

OC1=NC(SCC(NC2=CC=C(C=C2)Cl)=O)=NC(C3=CC=CN=C3)=C1C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ahmed A Al-Karmalawy, et al. Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments. J Med Chem. 2024 Jan 11;67(1):492-512. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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