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Cat. No.: HY-181841

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TLR8 agonist 10

TLR8 agonist 10 is a selective TLR8 agonist with an EC₅₀ of 0.019 μM in humans. TLR8 agonist 10 activates TLR8-mediated signaling pathways. As a latency-reversing agent, TLR8 agonist 10 reactivates latent HIV-1 reservoirs. TLR8 agonist 10 activates innate cytotoxic natural killer cells to target HIV-infected CD4⁺ T cells. TLR8 agonist 10 is applicable to research related to HIV-1 infection.

For research use only. We do not sell to patients.

CAS No.: 2796210-93-8
Formula: C₂₀H₃₀N₄
Molecular Weight:326.48

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Please store the product under the recommended conditions in the Certificate of Analysis.

TLR8 agonist 10 Chemical Structure

CAS No.: 2796210-93-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

IC₅₀ & Target

HIV-1

hTLR8

0.019 μM (IC₅₀)

All Toll-like Receptor (TLR) Isoforms :

All HIV Isoforms :

In Vitro

TLR8 agonist 10 (Compound 23A) (0-10 μM) potently reactivates latent HIV-1 in U1 cells in vitro without significant cytotoxicity^[1].
TLR8 agonist 10 (0-10 μM) can indirectly activate latent HIV-1 in ACH-2 cells via cytokine signals produced by treated human PBMCs, and exhibits no significant cytotoxicity against ACH-2 cells^[1].
TLR8 agonist 10 (0-10 μM) potently reactivates latent HIV-1 in OM10.1 cells in a concentration-dependent manner, with no significant cytotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	CL	V_ss	AUC_0-∞	C_max	AUC_inf	Bioavailability
Rat^[1]	1 mg/kg	i.v.	29.9 h	16.1 mL/min/kg	27.6 L/kg	1641 ng·h/mL	/	/	/
Rat^[1]	5 mg/kg	p.o.	26.8 h	/	/	/	64.9 ng/mL	2468 ng·h/mL	35 %

In Vivo

TLR8 agonist 10 (1-5 mg/kg; i.v., p.o.; single dose) exhibits favorable pharmacokinetic properties in male SD rats, with a long half-life, low clearance, and 35% oral bioavailability after a 5 mg/kg oral dose^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2796210-93-8
Molecular Weight 326.48
Formula C₂₀H₃₀N₄
SMILES

CCCCNC1=CC(CC2=CC=C(C=C2)CN(C)C)=C(N=C1N)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang Z, et al. Rational Design and Identification of Highly Selective TLR8 Agonists as Potent HIV-1 Latency Reversal Agents. J Med Chem. 2026;69(5):5405-5424. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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TLR8 agonist 10

All Toll-like Receptor (TLR) Isoforms

All HIV Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TLR8 agonist 10 Related Classifications

HY-181841 Related Classifications