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Art. -Nr.: HY-181841

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TLR8 agonist 10

TLR8 agonist 10 is a selective TLR8 agonist with an EC₅₀ of 0.019 μM in humans. TLR8 agonist 10 activates TLR8-mediated signaling pathways. As a latency-reversing agent, TLR8 agonist 10 reactivates latent HIV-1 reservoirs. TLR8 agonist 10 activates innate cytotoxic natural killer cells to target HIV-infected CD4⁺ T cells. TLR8 agonist 10 is applicable to research related to HIV-1 infection.

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CAS. Nr.: 2796210-93-8
Formel: C₂₀H₃₀N₄
Molecular Weight:326.48

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Please store the product under the recommended conditions in the Certificate of Analysis.

TLR8 agonist 10 Chemical Structure

CAS. Nr.: 2796210-93-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

HIV-1

hTLR8

0.019 μM (IC₅₀)

Alle Toll-like Receptor (TLR) Isoform-spezifische Produkte anzeigen :

Alle HIV Isoform-spezifische Produkte anzeigen :

In Vitro

TLR8 agonist 10 (Compound 23A) (0-10 μM) potently reactivates latent HIV-1 in U1 cells in vitro without significant cytotoxicity^[1].
TLR8 agonist 10 (0-10 μM) can indirectly activate latent HIV-1 in ACH-2 cells via cytokine signals produced by treated human PBMCs, and exhibits no significant cytotoxicity against ACH-2 cells^[1].
TLR8 agonist 10 (0-10 μM) potently reactivates latent HIV-1 in OM10.1 cells in a concentration-dependent manner, with no significant cytotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	CL	V_ss	AUC_0-∞	C_max	AUC_inf	Bioavailability
Rat^[1]	1 mg/kg	i.v.	29.9 h	16.1 mL/min/kg	27.6 L/kg	1641 ng·h/mL	/	/	/
Rat^[1]	5 mg/kg	p.o.	26.8 h	/	/	/	64.9 ng/mL	2468 ng·h/mL	35 %

In Vivo

TLR8 agonist 10 (1-5 mg/kg; i.v., p.o.; single dose) exhibits favorable pharmacokinetic properties in male SD rats, with a long half-life, low clearance, and 35% oral bioavailability after a 5 mg/kg oral dose^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2796210-93-8
Molecular Weight 326.48
Formel C₂₀H₃₀N₄
SMILES

CCCCNC1=CC(CC2=CC=C(C=C2)CN(C)C)=C(N=C1N)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Wang Z, et al. Rational Design and Identification of Highly Selective TLR8 Agonists as Potent HIV-1 Latency Reversal Agents. J Med Chem. 2026;69(5):5405-5424. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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TLR8 agonist 10

Alle Toll-like Receptor (TLR) Isoform-spezifische Produkte anzeigen

Alle HIV Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

TLR8 agonist 10 Related Classifications

HY-181841 Related Classifications