Trastuzumab duocarmazine
Based on 1 Customer Validation
Trastuzumab duocarmazine ((vic)-Trastuzumab duocarmazine) is a HER2-targeting ADC that is recognized and cleaved by histone B in tumor cells and selectively targets tumor cells. Trastuzumab duocarmazine has anti-tumor activity and can be used in cancer research related to uterine and ovarian sarcomas.
For research use only. We do not sell to patients.
- Purity : 99.87%
- CAS No.: 1642152-40-6
- Molecular Weight:149000 (average)
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Storage:
-80°C, protect from light
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Trastuzumab duocarmazine (SYD985) (0.0001-100 μg/mL, 24 h) is lethal to both HER2- and HER2+ cells, and is 7-fold more lethal to HER2/NEU3+ cell lines with the IC50 value of 0.013 μg/mL compared to T-DM1 with the IC50 value of 0.096 μg/mL. More importantly, in HER2/NEU1+ cells, it is 54 times more potent in killing cells compared to T-DM1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1642152-40-6
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Appearance Liquid
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Molecular Weight 149000 (average)
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Color Colorless to light yellow
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SMILES
[Trastuzumab duocarmazine]
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Synonyms
(vic)-Trastuzumab duocarmazine
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Shipping
Shipping with dry ice.
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Storage
-80°C, protect from light
Purity & Documentation
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trastuzumab duocarmazine Related Classifications
HY-P99547 Related Classifications
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