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Cat. No.: HY-122351AR

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Advantame (Standard)

Advantame (Standard) is the analytical standard of Advantame. This product is intended for research and analytical applications. Advantame is an N-substituted derivative of aspartame. Advantame is a high-intensity, low calorie sweetener. Advantame can interact with plasma protein. Advantame has the potential to produce hypotension and inhibit hERG K⁺ channel to produce carditoxicity. Advantame binds to T1R2/T1R3 taste GPCR to form an oligomeric functional selectivity of biased heteromers with NMBR to induce a significant sialidase activity in vitro. Advantame has maternal toxicity (gastrointestinal disturbances) in the prenatal developmental toxicity study in rabbits.

For research use only. We do not sell to patients.

Purity: 98%
CAS No.: 714229-20-6
Formula: C₂₄H₃₂N₂O₈
Molecular Weight:476.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Advantame (Standard) Chemical Structure

CAS No.: 714229-20-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 714229-20-6
Molecular Weight 476.52
Formula C₂₄H₃₂N₂O₈
SMILES

OC1=C(OC)C=CC(CCCN[C@@H](CC(O)=O)C(N[C@H](C(OC)=O)CC2=CC=CC=C2)=O)=C1.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Otabe, A., et al., (2011). Advantame--an overview of the toxicity data. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association, 49 Suppl 1, S2–S7. [Content Brief]

[2]. DENISA IOANA VOICULESCU, et al., (2021) COMPUTATIONAL ASSESSMENT OF THE PHARMACOKINETICS AND TOXICITY OF THE INTENSIVE SWEETENERS: Farmacia, 69, 6.

[3]. EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS), (2013), Scientific Opinion on the safety of advantame for the proposed uses as a food additive, 11(7).

[4]. Skapinker, E., et al., (2024). Artificial and Natural Sweeteners Biased T1R2/T1R3 Taste Receptors Transactivate Glycosylated Receptors on Cancer Cells to Induce Epithelial-Mesenchymal Transition of Metastatic Phenotype. Nutrients, 16(12), 1840. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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