ADCY4 - adenylate cyclase 4 Gene

Also Known as AC4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 196883

About ADCY4

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,318,359-24,335,071 (from NCBI)

This gene has 19 transcripts (splice variants), 1 gene allele, 181 orthologues and 17 paralogues. Broad expression in placenta (RPKM 14.4), fat (RPKM 11.6) and 23 other tissues.

Summary

This gene encodes a member of the family of adenylate cyclases, which are membrane-associated Enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that Adenylate Cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

ADCY4 Products (3)

mRNA	Protein	Name
NM_001198568.2	NP_001185497.1	adenylate cyclase type 4
NM_001198592.2	NP_001185521.1	adenylate cyclase type 4
NM_139247.4	NP_640340.2	adenylate cyclase type 4

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17081159	GOA
enables protein kinase C binding	IDA IDA: Inferred from direct assay	17081159	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11549699	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADCY4 Protein Structure

Guanylate_cyc

DUF1053

Guanylate_cyc

0
200
400
600
800
1000
1077 a.a.

Protein Preferred Names	Protein Names
adenylate cyclase type 4	ATP pyrophosphate-lyase 4

ADCY4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ADCY4	Q8NFM4	ESRRG	Homo sapiens	P62508-3	Y2H Prey Pooling	32296183
Intra	ADCY4	Q8NFM4	ESRRG	Homo sapiens	P62508-3	Y2H Array	32296183
Intra	ADCY4	Q8NFM4	C1orf50	Homo sapiens	Q9BV19	Validated Y2H	32296183
Intra	ADCY4	Q8NFM4	C1orf50	Homo sapiens	Q9BV19	Y2H Array	32296183
Intra	ADCY4	Q8NFM4	C1orf50	Homo sapiens	Q9BV19	Y2H Prey Pooling	32296183
Intra	ADCY4	Q8NFM4	PPARG	Homo sapiens	P37231	Y2H Array	32296183
Intra	ADCY4	Q8NFM4	PPARG	Homo sapiens	P37231	Y2H Prey Pooling	32296183
Intra	ADCY4	Q8NFM4	TTC23	Homo sapiens	Q5W5X9-3	Y2H Array	32296183
Intra	ADCY4	Q8NFM4	TTC23	Homo sapiens	Q5W5X9-3	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Amelogenesis Imperfecta, Type Iiic	AI3C Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Recessive Amelogenesis Imperfecta Type 3c Amelogenesis Imperfecta, Type 3c Amelogenesis Imperfecta Type Iiic Autosomal Recessive Amelogenesis Imperfecta Hypocalcification Type Amelogenesis Imperfecta 3c
Angiostrongyliasis	A. Cantonensis Angiostrongyliasis
Eosinophilic Meningitis	Eosinophilic Meningoencephalitis Due To Angiostrongylus Cantonensis
Gnathomiasis	Gnathostomiasis Infectious Disease By Gnathostoma Gnathostomosis Wandering Swelling
Amelogenesis Imperfecta, Type Iv	AI4 Aihht Amelogenesis Imperfecta Type 4 Hypomaturation-Hypoplastic Amelogenesis Imperfecta With Taurodontism Amelogenesis Imperfecta, Hypomaturation-Hypoplastic Type, With Taurodontism Amelogenesis Imperfecta Hypomaturation-Hypoplastic Type With Taurodontism Amelogenesis Imperfecta 4 Ait Amelogenesis Imperfecta 2 Hypocalcification Type Amelogenesis Imperfecta Hypomineralization Type Amelogenesis Imperfecta Type Iv Amelogenesis Imperfecta With Taurodontism
Chronic Meningitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00330	ADCY4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ADCY4	VGNC	VGNC:110581
Mus musculus	ADCY4	MGD	MGI:99674
Bos taurus	ADCY4	VGNC	VGNC:25645
Rattus norvegicus	ADCY4	RGD	RGD:2034
Felis catus	ADCY4	VGNC	VGNC:59617
Canis familiaris	ADCY4	VGNC	VGNC:37621
Others	ADCY4	NCBI