RBM15 - RNA binding motif protein 15 Gene

Also Known as OTT; OTT1; SPEN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64783

About RBM15

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:110,339,377-110,346,677 (from NCBI)

This gene has 9 transcripts (splice variants), 259 orthologues, 7 paralogues and is associated with 58 phenotypes. Broad expression in bone marrow (RPKM 6.3), testis (RPKM 2.8) and 24 other tissues.

Summary

Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]

RBM15 Products (2)

mRNA Protein Name
NM_001201545.2 NP_001188474.1 RNA-binding protein 15 isoform 2
NM_022768.5 NP_073605.4 RNA-binding protein 15 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
27602518 GOA
enables mRNA binding IDA
IDA: Inferred from direct assay
26575292 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16129689 GOA
Biological Process GO Annotation Evidence References Source
involved in RNA methylation IDA
IDA: Inferred from direct assay
27602518 GOA
involved in dosage compensation by inactivation of X chromosome IDA
IDA: Inferred from direct assay
27602518 GOA
NOT involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16129689 GOA
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
26575292 GOA
involved in regulation of megakaryocyte differentiation IDA
IDA: Inferred from direct assay
26575292 GOA
Cellular Component GO Annotation Evidence References Source
part of RNA N6-methyladenosine methyltransferase complex IDA
IDA: Inferred from direct assay
27602518 GOA
located in nuclear speck IDA
IDA: Inferred from direct assay
24100041 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
24100041 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM15 Protein Structure

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (190 - 248)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (376 - 444)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (471 - 527)

SPOC

SPOC: SPOC domain (788 - 924)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 977 a.a.
Protein Preferred Names Protein Names

RNA-binding protein 15

  • one twenty two protein

RBM15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RBM15 Q96T37 CALCOCO2 Homo sapiens Q13137
Validated Y2H
25416956
Intra
RBM15 Q96T37 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
Intra
RBM15 Q96T37 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
Intra
RBM15 Q96T37 NAV2 Homo sapiens Q8IVL1
Validated Y2H
25416956
Intra
RBM15 Q96T37 NAV2 Homo sapiens Q8IVL1
Y2H Prey Pooling
25416956
Intra
RBM15 Q96T37 CEP44 Homo sapiens Q9C0F1
Validated Y2H
25416956
Intra
RBM15 Q96T37 CEP44 Homo sapiens Q9C0F1
Y2H Prey Pooling
25416956
Intra
RBM15 Q96T37 CEP44 Homo sapiens Q9C0F1
Y2H Array
25416956
Intra
RBM15 Q96T37 DDX17 Homo sapiens Q92841
Y2H Array
25416956
Intra
RBM15 Q96T37 DDX17 Homo sapiens Q92841
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Megakaryoblastic Acute Myeloid Leukemia With T(1;22)(P13;Q13)

  • Megakaryoblastic Aml With T(1

  • 22)(P13

  • Q13)
Acute Megakaryocytic Leukemia

  • Acute Megakaryoblastic Leukemia

  • Acute Megakaryoblastic Leukaemia

  • Megakaryocytic Myelosis

  • Thrombocytic Leukaemia

  • Amkl

  • Aml M7

  • Acute Myeloblastic Leukemia Type 7

  • Acute Myeloid Leukemia M7

  • Megakaryoblastic Leukemia Acute

  • Leukemia, Megakaryoblastic, Acute

  • Acute Myeloid Leukaemia, M7

  • Acute Megakaryocytic Leukaemia

  • Acute Megakaryoblastic Leukaemia, Fab M7

  • Fab M7

  • Malignant Megakaryocytosis

  • M7 - Acute Megakaryoblastic Leukaemia

  • Megakaryoblastic Leukaemia

  • Megakaryocytic Leukaemia

  • Acute Megakaryoblastic Leukaemia, Nos

  • Acute Megakaryoblastic Leukaemia Without Mention Of Remission
Neonatal Leukemia
Myeloproliferative Syndrome, Transient

  • Transient Abnormal Myelopoiesis

  • Transient Myeloproliferative Syndrome

  • Transient Myeloproliferative Disease

  • Mst

  • Tam

  • Leukemia, Transient, Of Down Syndrome

  • Tmd

  • Leukemia, Transient

  • Transient Leukemia

  • Transient Leukemia Of Down Syndrome
Chromosome 1p36 Deletion Syndrome

  • 1p36 Deletion Syndrome

  • Deletion 1p36

  • Monosomy 1p36

  • Subtelomeric 1p36 Deletion

  • Monosomy 1p36 Syndrome

  • Distal Monosomy 1p36

  • Del(1)(P36)

  • Deletion 1pter

  • Monosomy 1pter
Wilms Tumor 1

  • Nephroblastoma

  • Wilms Tumor

  • WT1

  • Wilms' Tumor

  • Bilateral Wilms Tumor

  • Wilms Tumor, Type 1

  • Wilms Tumor, Somatic

  • Adult Nephroblastoma

  • Wt1 Disorder

  • Renal Embryonic Tumor

  • Adult Kidney Wilms Tumor

  • Childhood Kidney Wilms Tumor

  • Nonanaplastic Kidney Wilms Tumor
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11735 RBM15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11736 RBM15B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19032 Rbm15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25521 Rbm15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RBM15 RGD RGD:1592713
Felis catus RBM15 VGNC VGNC:64521
Macaca mulatta RBM15 VGNC VGNC:76481
Mus musculus RBM15 MGD MGI:2443205
Canis familiaris RBM15 VGNC VGNC:45409
Bos taurus RBM15 VGNC VGNC:33787
Others RBM15 NCBI