PSMA targeting peptide
Based on 1 publication(s) in Google Scholar
PSMA targeting peptide (PSMA-1) is a PSMA-binding peptide that selectively binds to the PSMA receptor on prostate cancer cells and acts as a peptide-based siRNA delivery system by complexing and releasing siRNA. PSMA targeting peptide can be used in research on prostate cancer.
For research use only. We do not sell to patients.
- CAS No.: 2042750-71-8
- Formula: C70H122N24O19
- Molecular Weight:1603.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) PSMA targeting peptide
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Biological Activity
Description
IC50 & Target
IC50: PSMA[1]
In Vitro
PSMA-1-R6 forms large, anionic, polydisperse complexes with siRNA, with a zeta potential of -2.16 mV, effective diameters of 1450 nm (aggregates) and 878 nm (individual particles), and a tendency to aggregate[1].
PSMA-1-R6 (5 min; 1 week), when complexed with siRNA, formed large, polydisperse aggregated particles with an average size 200-300 nm larger than that of the siRNA:Trans-IT X2 control complexes[1].
PSMA-1-R6 peptide (625 pmol; 48 h) failed to mediate functional siRNA delivery and GRP78 knockdown at both mRNA and protein levels in both LNCaP and PC3 cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2042750-71-8
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Molecular Weight 1603.87
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Formula C70H122N24O19
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Synonyms
PSMA-1
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Sequence
Gly-Arg-Phe-Leu-Thr-Gly-Gly-Thr-Gly-Arg-Leu-Leu-Arg-Ile-Ser
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Sequence Shortening
GRFLTGGTGRLLRIS
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Control Release
Targeting polyamine metabolism induces oxidative/carbonyl stress to reinvigorate antitumor immunity in prostate cancer. [Abstract]2025 Sep 30;388(Pt 1):114283. PMID: 41038348
Protocols
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RNA interference technology
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing gene transcription or activating RNA degradation. This mechanism was discovered in plants in 1998 by Andrew Fire and Craig Mello. Today, this phenomenon can be observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PSMA targeting peptide Related Classifications
HY-P10055 Related Classifications
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