1. Protein Tyrosine Kinase/RTK
    MAPK/ERK Pathway
    Apoptosis
  2. VEGFR
    Raf
    Apoptosis
  3. VEGFR-2/BRAF-IN-2

VEGFR-2/BRAF-IN-2 

Cat. No.: HY-146492
Handling Instructions

VEGFR-2/BRAF-IN-2 (Compound 4a) is a dual VEGFR-2 and BRAF kinases inhibitor with IC50 values of 0.111, 0.089 and 0.071 µM against VEGFR-2, BRAFV600E and BRAFWT, respectively. VEGFR-2/BRAF-IN-2 induces apoptosis and arrests the cell cycle mainly in the G1 phase.

For research use only. We do not sell to patients.

VEGFR-2/BRAF-IN-2 Chemical Structure

VEGFR-2/BRAF-IN-2 Chemical Structure

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Description

VEGFR-2/BRAF-IN-2 (Compound 4a) is a dual VEGFR-2 and BRAF kinases inhibitor with IC50 values of 0.111, 0.089 and 0.071 µM against VEGFR-2, BRAFV600E and BRAFWT, respectively. VEGFR-2/BRAF-IN-2 induces apoptosis and arrests the cell cycle mainly in the G1 phase[1].

IC50 & Target

BRAFWT

0.071 μM (IC50)

BRafV600E

0.089 μM (IC50)

VEGFR2

0.111 μM (IC50)

Molecular Weight

608.05

Formula

C26H21ClF3N5O3S2

SMILES

FC(F)(F)C1=CC=CC(NC(NNC(CSC2=NC3=C(C4=C(S3)CCCC4)C(N2C5=CC=C(C=C5)Cl)=O)=O)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
VEGFR-2/BRAF-IN-2
Cat. No.:
HY-146492
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