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Cat. No.: HY-163544

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δ-Tocotrienol prodrug-1

δ-Tocotrienol prodrug-1 (compound 5b) is a prodrug of δ-tocotrienol (HY-122778). δ-Tocotrienol prodrug-1 shows radioprotective efficacy. δ-Tocotrienol prodrug-1 promotes the hematopoietic progenitor and stem cell regeneration in murine bone marrow and spleen.

For research use only. We do not sell to patients.

CAS No.: 128254-90-0
Formula: C₃₁H₄₄O₅
Molecular Weight:496.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

δ-Tocotrienol prodrug-1 Chemical Structure

CAS No.: 128254-90-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vivo

δ-Tocotrienol prodrug-1 (compound 5b) (100 mg/kg; s.c.; once) shows radioprotective efficacy^[1].
Pharmacokinetic Parameters^[1].

Parameters	100 mg/kg (i.v./DT3)	100 mg/kg (s.c./DT3)
t_max (h)	0.083	0.67
C_max (ng/ml)	5.15 × 10⁵	2.02 × 10³
t_1/2 (h)	10.40	26.76
AUC_(0-t) (h ng/mL)	1.96×10⁵	0.27×10⁵
AUC_(0-∞) (h ng/ mL)	2.06×10⁵	0.54×10⁵
CL (mL/h/kg)	225.32	-
MRT_(0-t) (h)	1.36	11.89
MRT_(0-∞) (h)	3.47	38.38
V_(dss) (mL/kg)	336.58	-
F %	-	13.86

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

21-24 g C57BL/6J male mice^[1]
Dosage:

100 mg/kg
Administration:

S.c.;once; 24 h prior to 8.5 Gy or 9.5 Gy total-body irradiation (TBI)
Result:

showed 90 % survival rate at 30 days in mice.

Chemical Information

CAS No. 128254-90-0
Molecular Weight 496.68
Formula C₃₁H₄₄O₅
SMILES

CC1=C2C(CC[C@](C)(O2)CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)=CC(OC(CCC(O)=O)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zuo Z, et al. Radioprotective effectiveness of a novel delta-tocotrienol prodrug on mouse hematopoietic system against 60Co gamma-ray irradiation through inducing granulocyte-colony stimulating factor production. Eur J Med Chem. 2024 Apr 5;269:116346. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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