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  3. Prostaglandin Receptor
  4. 17-Phenyl trinor PGF2α isopropyl ester

17-Phenyl trinor PGF2α isopropyl ester 

Cat. No.: HY-116161A Purity: 99.76%
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17-Phenyl trinor PGF2α isopropyl ester is a FP receptor agonist and intraocular pressure-lowering agent. 17-Phenyl trinor PGF2α isopropyl ester induces iris sphincter contraction, reduces intraocular pressure and pupil diameter, causes no ocular irritation, and only leads to mild conjunctival hyperemia. 17-Phenyl trinor PGF2α isopropyl ester is applicable to relevant research on glaucoma.

For research use only. We do not sell to patients.

17-Phenyl trinor PGF2α isopropyl ester

17-Phenyl trinor PGF2α isopropyl ester Chemical Structure

CAS No. : 130209-76-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

Other Forms of 17-Phenyl trinor PGF2α isopropyl ester:

17-Phenyl trinor PGF2α isopropyl ester Related Antibodies

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Description

17-Phenyl trinor PGF2α isopropyl ester is a FP receptor agonist and intraocular pressure-lowering agent. 17-Phenyl trinor PGF2α isopropyl ester induces iris sphincter contraction, reduces intraocular pressure and pupil diameter, causes no ocular irritation, and only leads to mild conjunctival hyperemia. 17-Phenyl trinor PGF2α isopropyl ester is applicable to relevant research on glaucoma[1][2].

In Vivo

17-Phenyl trinor PGF2α isopropyl ester (Compound 3b) (3 μg; single topical ocular administration) induces a statistically significant maximum IOP reduction of 2.9 mmHg in normotensive cynomolgus monkeys[1].
17-Phenyl trinor PGF2α isopropyl ester (3 μg; ocular surface administration; single dose) induces mild ocular irritation in domestic female cats[1].
17-Phenyl trinor PGF2α isopropyl ester (0.03-3 μg; single ocular administration) induces dose-dependent mild conjunctival hyperemia in New Zealand albino rabbits[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkeys[1]
Dosage: 3 μg
Administration: o.a.; single dose
Result: Produced a maximum reduction in IOP of 2.9 mmHg.
Animal Model: Domestic female cats (2-3 kg)[1]
Dosage: 3 μg
Administration: o.a.; single dose
Result: Caused a maximum irritation score of 0.2 arbitrary units, which was significantly lower than the irritation induced by PGF2α isopropyl ester (1b).
Animal Model: New Zealand White albino rabbits (2-3 kg)[1]
Dosage: 0.03 μg, 0.1 μg, 0.3 μg, 1 μg, 3 μg
Administration: o.a.; single dose
Result: Induced mild conjunctival hyperemia, with maximum difference scores (experimental eye vs. control eye) of approximately 0.8, 1.0, 1.4, 1.5, and 1.7 arbitrary units at doses of 0.03 μg, 0.1 μg, 0.3 μg, 1 μg, and 3 μg, respectively; this hyperemia was significantly less pronounced than that induced by PGF2α isopropyl ester (1b).
Molecular Weight

430.58

Formula

C26H38O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OC(C)C)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C[C@@H]1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (232.24 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3224 mL 11.6122 mL 23.2245 mL
5 mM 0.4645 mL 2.3224 mL 4.6449 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3224 mL 11.6122 mL 23.2245 mL 58.0612 mL
5 mM 0.4645 mL 2.3224 mL 4.6449 mL 11.6122 mL
10 mM 0.2322 mL 1.1612 mL 2.3224 mL 5.8061 mL
15 mM 0.1548 mL 0.7741 mL 1.5483 mL 3.8707 mL
20 mM 0.1161 mL 0.5806 mL 1.1612 mL 2.9031 mL
25 mM 0.0929 mL 0.4645 mL 0.9290 mL 2.3224 mL
30 mM 0.0774 mL 0.3871 mL 0.7741 mL 1.9354 mL
40 mM 0.0581 mL 0.2903 mL 0.5806 mL 1.4515 mL
50 mM 0.0464 mL 0.2322 mL 0.4645 mL 1.1612 mL
60 mM 0.0387 mL 0.1935 mL 0.3871 mL 0.9677 mL
80 mM 0.0290 mL 0.1452 mL 0.2903 mL 0.7258 mL
100 mM 0.0232 mL 0.1161 mL 0.2322 mL 0.5806 mL
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17-Phenyl trinor PGF2α isopropyl ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

17-Phenyl trinor PGF2α isopropyl ester130209-76-6Prostaglandin Receptorglaucomairis sphincter musclenormotensive cynomolgus monkeysdomestic female catsNew Zealand White albino rabbitsFP receptorintraocular pressureInhibitorinhibitorinhibit

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