17-Phenyl trinor PGF2α isopropyl ester
Based on 1 Customer Validation
17-Phenyl trinor PGF2α isopropyl ester is a FP receptor agonist and intraocular pressure-lowering agent. 17-Phenyl trinor PGF2α isopropyl ester induces iris sphincter contraction, reduces intraocular pressure and pupil diameter, causes no ocular irritation, and only leads to mild conjunctival hyperemia. 17-Phenyl trinor PGF2α isopropyl ester is applicable to relevant research on glaucoma.
For research use only. We do not sell to patients.
- Purity: 99.76%
- CAS No.: 130209-76-6
- Formula: C26H38O5
- Molecular Weight:430.58
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
17-Phenyl trinor PGF2α isopropyl ester (3 μg; ocular surface administration; single dose) induces mild ocular irritation in domestic female cats[1].
17-Phenyl trinor PGF2α isopropyl ester (0.03-3 μg; single ocular administration) induces dose-dependent mild conjunctival hyperemia in New Zealand albino rabbits[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Cynomolgus monkeys[1]
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Dosage:3 μg
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Administration:o.a.; single dose
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Result:Produced a maximum reduction in IOP of 2.9 mmHg.
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Animal Model:Domestic female cats (2-3 kg)[1]
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Dosage:3 μg
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Administration:o.a.; single dose
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Result:Caused a maximum irritation score of 0.2 arbitrary units, which was significantly lower than the irritation induced by PGF2α isopropyl ester (1b).
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Animal Model:New Zealand White albino rabbits (2-3 kg)[1]
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Dosage:0.03 μg, 0.1 μg, 0.3 μg, 1 μg, 3 μg
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Administration:o.a.; single dose
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Result:Induced mild conjunctival hyperemia, with maximum difference scores (experimental eye vs. control eye) of approximately 0.8, 1.0, 1.4, 1.5, and 1.7 arbitrary units at doses of 0.03 μg, 0.1 μg, 0.3 μg, 1 μg, and 3 μg, respectively; this hyperemia was significantly less pronounced than that induced by PGF2α isopropyl ester (1b).
Chemical Information
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CAS No. 130209-76-6
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Appearance Solid
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Molecular Weight 430.58
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Formula C26H38O5
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Color White to off-white
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SMILES
O=C(OC(C)C)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C[C@@H]1O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (232.24 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
References
[1]. Resul B, et al. Phenyl-substituted prostaglandins: potent and selective antiglaucoma agents. J Med Chem. 1993;36(2):243-248. [Content Brief]
[2]. Abramovitz M, et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000;1483(2):285-293. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3224 mL | 11.6122 mL | 23.2245 mL | 58.0612 mL |
| 5 mM | 0.4645 mL | 2.3224 mL | 4.6449 mL | 11.6122 mL | |
| 10 mM | 0.2322 mL | 1.1612 mL | 2.3224 mL | 5.8061 mL | |
| 15 mM | 0.1548 mL | 0.7741 mL | 1.5483 mL | 3.8707 mL | |
| 20 mM | 0.1161 mL | 0.5806 mL | 1.1612 mL | 2.9031 mL | |
| 25 mM | 0.0929 mL | 0.4645 mL | 0.9290 mL | 2.3224 mL | |
| 30 mM | 0.0774 mL | 0.3871 mL | 0.7741 mL | 1.9354 mL | |
| 40 mM | 0.0581 mL | 0.2903 mL | 0.5806 mL | 1.4515 mL | |
| 50 mM | 0.0464 mL | 0.2322 mL | 0.4645 mL | 1.1612 mL | |
| 60 mM | 0.0387 mL | 0.1935 mL | 0.3871 mL | 0.9677 mL | |
| 80 mM | 0.0290 mL | 0.1452 mL | 0.2903 mL | 0.7258 mL | |
| 100 mM | 0.0232 mL | 0.1161 mL | 0.2322 mL | 0.5806 mL |
17-Phenyl trinor PGF2α isopropyl ester Related Classifications
HY-116161A Related Classifications
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