(25S)-Δ7-Dafachronic acid
Based on 1 Customer Validation
(25S)-Δ7-Dafachronic acid is a ligand and activator of DAF-12 receptor. DAF-12 is a nuclear hormone receptor that regulates larval diapause, developmental age, and adult longevity in Caenorhabditis elegans.
For research use only. We do not sell to patients.
- Purity: 96.92%
- CAS No.: 949004-12-0
- Formula: C27H42O3
- Molecular Weight:414.62
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
(25S)-Δ7-Dafachronic acid is a potent transcriptional activator in a Gal4-transactivation assay using HEK-293 cells (EC50: 33 nM)[2].
(25S)-Δ7-Dafachronic acid (10 μM, 48 h) stimulates larval growth and development[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 949004-12-0
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Appearance Solid
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Molecular Weight 414.62
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Formula C27H42O3
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Color White to off-white
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SMILES
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC[C@H](C)C(O)=O)([H])C3=CC[C@](CC(CC4)=O)([H])[C@@]4(C)[C@@]3([H])CC1
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Synonyms
Dafachronic acid A; Δ7-Dafachronic acid
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[3]. Sharma KK, et al. Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor. Mol Endocrinol. 2009 May;23(5):640-8. [Content Brief]
[4]. Ma G, et al. Dafachronic acid promotes larval development in Haemonchus contortus by modulating dauer signalling and lipid metabolism. PLoS Pathog. 2019 Jul 23;15(7):e1007960. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(25S)-Δ7-Dafachronic acid Related Classifications
HY-130221 Related Classifications
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