2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. 3α,21-Dihydroxy-5α-pregnan-20-one

3α,21-Dihydroxy-5α-pregnan-20-one  (Synonyms: THDOC)

Cat. No.: HY-123489 Purity: 98.0%
COA
SDS
Handling Instructions Technical Support

3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro.

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3α,21-Dihydroxy-5α-pregnan-20-one

3α,21-Dihydroxy-5α-pregnan-20-one 화학구조

CAS No. : 567-02-2

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

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Other Forms of 3α,21-Dihydroxy-5α-pregnan-20-one:

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제품 설명

3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro.

분자량

334.49

화학식

C21H34O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@H](CC[C@]1([C@@]3(CC[C@]4(C[C@@H](CC[C@@]4([C@]3(CC2)[H])C)O)[H])[H])[H])C(CO)=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 100 mg/mL (298.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9896 mL 14.9481 mL 29.8963 mL
5 mM 0.5979 mL 2.9896 mL 5.9793 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
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순도&문서

Purity: 98.0%

SDS (480 KB)

COA (251 KB) HNMR (254 KB) MS (81 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9896 mL 14.9481 mL 29.8963 mL 74.7407 mL
5 mM 0.5979 mL 2.9896 mL 5.9793 mL 14.9481 mL
10 mM 0.2990 mL 1.4948 mL 2.9896 mL 7.4741 mL
15 mM 0.1993 mL 0.9965 mL 1.9931 mL 4.9827 mL
20 mM 0.1495 mL 0.7474 mL 1.4948 mL 3.7370 mL
25 mM 0.1196 mL 0.5979 mL 1.1959 mL 2.9896 mL
30 mM 0.0997 mL 0.4983 mL 0.9965 mL 2.4914 mL
40 mM 0.0747 mL 0.3737 mL 0.7474 mL 1.8685 mL
50 mM 0.0598 mL 0.2990 mL 0.5979 mL 1.4948 mL
60 mM 0.0498 mL 0.2491 mL 0.4983 mL 1.2457 mL
80 mM 0.0374 mL 0.1869 mL 0.3737 mL 0.9343 mL
100 mM 0.0299 mL 0.1495 mL 0.2990 mL 0.7474 mL
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3α,21-Dihydroxy-5α-pregnan-20-one Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3α,21-Dihydroxy-5α-pregnan-20-one567-02-2THDOCGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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상품명:
3α,21-Dihydroxy-5α-pregnan-20-one
Cat. No.:
HY-123489
수량:
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