1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. Nucleoside Antimetabolite/Analog
    DNA/RNA Synthesis
    Endogenous Metabolite
  3. 3'-Deoxyuridine-5'-triphosphate

3'-Deoxyuridine-5'-triphosphate (Synonyms: 3'-dUTP)

Cat. No.: HY-135780
Handling Instructions

3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM.

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3'-Deoxyuridine-5'-triphosphate Chemical Structure

3'-Deoxyuridine-5'-triphosphate Chemical Structure

CAS No. : 69199-40-2

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Description

3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM[1].

In Vitro

3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is synthesized starting from cordycepin in good yield. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA by the RNA polymerases. 3'-Deoxyuridine-5'-triphosphate will be useful in studies at the molecular level on the relationship of template and substrate in RNA synthesis with chromatin, isolated nuclei or permeable cells, because it does not have any effect on poly (rA) synthesis[1].

Molecular Weight

468.14

Formula

C₉H₁₅N₂O₁₄P₃

CAS No.

69199-40-2

SMILES

O[[email protected]@H]([[email protected]](N1C(NC(C=C1)=O)=O)O2)C[[email protected]]2COP(O)(OP(O)(OP(O)(O)=O)=O)=O

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Keywords:

3'-Deoxyuridine-5'-triphosphate3'-dUTPNucleoside Antimetabolite/AnalogDNA/RNA SynthesisEndogenous MetaboliteDNA-dependentRNApolymerases Ipolymerases IIUTPInhibitorinhibitorinhibit

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3'-Deoxyuridine-5'-triphosphate
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