1. Cell Cycle/DNA Damage
    Anti-infection
  2. Nucleoside Antimetabolite/Analog
    DNA/RNA Synthesis
    CMV
  3. Enocitabine

Enocitabine 

Cat. No.: HY-123523 Purity: >98.0%
Handling Instructions

Enocitabine is a nucleoside analog, and is a potent DNA replication inhibitor, and a DNA chain terminator. Enocitabine inhibits the replication of human cytomegalovirus. Enocitabine has antileukemic and antiviral activities.

For research use only. We do not sell to patients.

Enocitabine Chemical Structure

Enocitabine Chemical Structure

CAS No. : 55726-47-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 705 In-stock
Estimated Time of Arrival: December 31
5 mg USD 566 In-stock
Estimated Time of Arrival: December 31
10 mg USD 965 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Enocitabine is a nucleoside analog, and is a potent DNA replication inhibitor, and a DNA chain terminator. Enocitabine inhibits the replication of human cytomegalovirus. Enocitabine has antileukemic and antiviral activities[1][2][3].

IC50 & Target

DNA replication[1]; CMV[3]

In Vitro

Enocitabine is resistant to deamination because Enocitabine bears a highly lipophilic group at the 4-amino position of the cytosine moiety of cytarabine[1].
The combined effects of Pirarubicin and Enocitabine on HeLa S3 human uterine cervix carcinoma and K562 human myelocytic leukemia cells are determined by enhancement of their cytotoxic activities. Enocitabine or etoposide shows synergistic effects on HeLa S3 and K562 cells[2].
In the presence of Enocitabine, triphosphate forms of the nucleoside analogs are detected in the human cytomegalovirus (HCMV)-infected cells, and synthesis of HCMV DNA is strongly suppressed[3].

Molecular Weight

565.78

Formula

C₃₁H₅₅N₃O₆

CAS No.

55726-47-1

SMILES

CCCCCCCCCCCCCCCCCCCCCC(NC(C=CN1[[email protected]]2[[email protected]@H](O)[[email protected]](O)[[email protected]](O2)CO)=NC1=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Keywords:

EnocitabineNucleoside Antimetabolite/AnalogDNA/RNA SynthesisCMVCytomegalovirusacute myelogenous leukaemiaAMLSunrabinInhibitorinhibitorinhibit

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Enocitabine
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