1. Metabolic Enzyme/Protease
  2. ROR
  3. 3-Oxo-5β-cholanoic acid

3-Oxo-5β-cholanoic acid (Synonyms: Dehydrolithocholic acid; 3-oxoLCA)

Cat. No.: HY-125801
Handling Instructions

3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM).

For research use only. We do not sell to patients.

3-Oxo-5β-cholanoic acid Chemical Structure

3-Oxo-5β-cholanoic acid Chemical Structure

CAS No. : 1553-56-6

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Description

3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM)[1].

In Vitro

Treatment with 3-Oxo-5β-cholanoic acid significantly reduced the activity of the RORγt reporter. These data suggest that 3-Oxo-5β-cholanoic acid probably inhibits TH17 cell differentiation by physically interacting with RORγt, and inhibiting its transcriptional activity[1].

In Vivo

3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (0.3% (w/w); p.o.; for 1 week) significantly reduces the percentage of ileal TH17 cells[1].

Animal Model: B6 Jax mice (with a faecal slurry containing SFB)[1]
Dosage: 0.3% (w/w)
Administration: Gavaged; for 1 week
Result: Significantly reduced the percentage of ileal TH17 cells.
Molecular Weight

374.56

Formula

C₂₄H₃₈O₃

CAS No.

1553-56-6

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Keywords:

3-Oxo-5β-cholanoic acidDehydrolithocholic acid3-oxoLCARORRAR-related orphan receptorTH17celldifferentiationbileacidtranscriptionfactorimmuneresponsesRORγtInhibitorinhibitorinhibit

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3-Oxo-5β-cholanoic acid
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HY-125801
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