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Cat. No.: HY-W507839

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4',5-Dihydroxy-3,3',7,8-tetramethoxyflavone

4',5-Dihydroxy-3,3',7,8-tetramethoxyflavone is a 3-methoxyflavonoid compound. 4',5-Dihydroxy-3,3',7,8-tetramethoxyflavone inhibits α-Amylase.

For research use only. We do not sell to patients.

CAS No.: 571-71-1
Formula: C₁₉H₁₈O₈
Molecular Weight:374.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

4',5-Dihydroxy-3,3',7,8-tetramethoxyflavone Chemical Structure

CAS No.: 571-71-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

4',5-Dihydroxy-3,3',7,8-tetramethoxyflavone is a 3-methoxyflavonoid compound. 4',5-Dihydroxy-3,3',7,8-tetramethoxyflavone inhibits α-Amylase^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Vero	ED₅₀	10 μM Compound: 3, Ternatin	Antiviral activity against 10'-2 MOI Human adenovirus 2 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect Antiviral activity against 10'-2 MOI Human adenovirus 2 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect	10.1021/np50070a036
Vero	ED₅₀	100 μM Compound: 3, Ternatin	Antiviral activity against 10'-2 MOI HSV2 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect Antiviral activity against 10'-2 MOI HSV2 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect	10.1021/np50070a036
Vero	ED₅₀	14 μM Compound: 3, Ternatin	Antiviral activity against 10'-3 MOI HSV2 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect Antiviral activity against 10'-3 MOI HSV2 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect	10.1021/np50070a036
Vero	ED₅₀	3 μM Compound: 3, Ternatin	Antiviral activity against 10'-3 MOI Poliovirus type 2 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect Antiviral activity against 10'-3 MOI Poliovirus type 2 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect	10.1021/np50070a036
Vero	ED₅₀	38 μM Compound: 3, Ternatin	Antiviral activity against 10'-3 MOI VSV infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect Antiviral activity against 10'-3 MOI VSV infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect	10.1021/np50070a036
Vero	ED₅₀	4 μM Compound: 3, Ternatin	Antiviral activity against 10'-2 MOI Poliovirus type 2 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect Antiviral activity against 10'-2 MOI Poliovirus type 2 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect	10.1021/np50070a036
Vero	ED₅₀	44 μM Compound: 3, Ternatin	Antiviral activity against 10'-3 MOI HSV1 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect Antiviral activity against 10'-3 MOI HSV1 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect	10.1021/np50070a036
Vero	ED₅₀	48 μM Compound: 3, Ternatin	Antiviral activity against 10'-2 MOI VSV infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect Antiviral activity against 10'-2 MOI VSV infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect	10.1021/np50070a036

In Vitro

4',5-Dihydroxy-3,3',7,8-tetramethoxyflavone (Compound 20) at concentrations of 100-500 μM inhibits porcine pancreatic α-amylase, with an inhibition rate ranging from 18% to 42% at 500 μM as determined by the iodine-starch method^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 571-71-1
Molecular Weight 374.35
Formula C₁₉H₁₈O₈
SMILES

O=C1C(OC)=C(OC2=C(OC)C(OC)=CC(O)=C12)C=3C=CC(O)=C(OC)C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tundis R, et al. Natural products as alpha-amylase and alpha-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: an update. Mini reviews in medicinal chemistry. 2010 Apr;10(4):315-31. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

4',5-Dihydroxy-3,3',7,8-tetramethoxyflavone

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Biological Activity
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4',5-Dihydroxy-3,3',7,8-tetramethoxyflavone

Biological Activity

Description

Cellular Effect

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

4',5-Dihydroxy-3,3',7,8-tetramethoxyflavone Related Classifications

HY-W507839 Related Classifications

Bioz

Keywords

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