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Cat. No.: HY-187353

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5-HT2A agonist-12

5-HT2A agonist-12 is a human 5-HT2A receptor agonist with an EC₅₀ of 0.78 μM (in Chinese hamster ovary cells). 5-HT2A agonist-12 modulates intracellular calcium mobilization in cells expressing the human 5-HT2A receptor. 5-HT2A agonist-12 can be used in research related to depression.

For research use only. We do not sell to patients.

CAS No.: 3129083-71-9
Formula: C₂₄H₂₁FN₄O₂S
Molecular Weight:448.51

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Please store the product under the recommended conditions in the Certificate of Analysis.

5-HT2A agonist-12 Chemical Structure

CAS No.: 3129083-71-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

IC₅₀ & Target

^[1]

5-HT_2A Receptor

All 5-HT Receptor Isoforms :

In Vitro

5-HT2A agonist-12 (Compound 4) acts as both an agonist (EC₅₀ = 0.78 μM, E_max = 68%) and a positive allosteric modulator (EC₅₀ = 0.074 μM, E_max = 53%) for the human 5-HT2A receptor. This assay is performed via a calcium mobilization experiment in Chinese hamster ovary cells expressing the receptor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3129083-71-9
Molecular Weight 448.51
Formula C₂₄H₂₁FN₄O₂S
SMILES

FC1=CC=C(C2=CC=C(S(=O)(C)=NC3=CN=C(OC4=CC(C)=NC(C)=C4)N=C3)C=C2)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Anna C. Renner, et al. Kargbo; Advancing Next-Generation Psychedelic Therapeutics through Selective 5-HT2A Activation, Precision Aerosol Delivery, and Optimized 5-MeO-DMT Treatment Paradigms. ACS Med. Chem. Lett. 2026;

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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5-HT2A agonist-12

All 5-HT Receptor Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

5-HT2A agonist-12 Related Classifications

HY-187353 Related Classifications

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