5-HT7R antagonist 4
5-HT7R antagonist 4 (Compound 4) is a potent 5-HT7 receptor antagonist (Ki=2.6 nM) with low binding affinity for the 5-HT1A receptor (Ki= 476 nM). 5-HT7R antagonist 4 is promising for research of neurological diseases.
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- No. CAS: 1386927-90-7
- Fòrmula: C17H20N2O
- Peso molecular:268.35
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
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5-HT7 Receptor 2.6 nM (Ki) |
5-HT1A Receptor 476 nM (Ki) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
438 nM
Compound: 9a
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Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA
Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA
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[PMID: 22738316] |
Chemical Information
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No. CAS 1386927-90-7
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Peso molecular 268.35
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Fòrmula C17H20N2O
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SMILES
COC1=CC=C(C=C1)C2=CC=CC=C2N3CCNCC3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)