5'-ODMT cEt G Phosphoramidite (Amidite)
Based on 1 Customer Validation
5'-ODMT cEt G Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt G Phosphoramidite Amidite shows excellent safety and antisense activity.
For research use only. We do not sell to patients.
- Purity: 99.43%
- CAS No.: 945628-66-0
- Formula: C46H56N7O9P
- Molecular Weight:881.95
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Storage:
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
5'-ODMT cEt G Phosphoramidite Amidite enhances the RNA-binding ability, affects the construction of antisense oligonucleotides (ASOs) and reduces the toxicity of ASOs through alternation of nucleotides conformation and 5'-alkyl DNA modification[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 945628-66-0
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Appearance Solid
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Molecular Weight 881.95
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Formula C46H56N7O9P
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Color White to off-white
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SMILES
CC(C)N(C(C)C)P(OCCC#N)O[C@@H]([C@](O[C@H]1C)([H])[C@H](N2C3=C(C(N=C(N3)NC(C(C)C)=O)=O)N=C2)O4)[C@@]41COC(C5=CC=C(C=C5)OC)(C6=CC=CC=C6)C7=CC=C(C=C7)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (113.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Vasquez G, et al. Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839. [Content Brief]
[2]. Seth PP, et al. Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues. J Org Chem. 2010 Mar 5;75(5):1569-81. [Content Brief]
[3]. Vasquez G, et al., Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1339 mL | 5.6693 mL | 11.3385 mL | 28.3463 mL |
| 5 mM | 0.2268 mL | 1.1339 mL | 2.2677 mL | 5.6693 mL | |
| 10 mM | 0.1134 mL | 0.5669 mL | 1.1339 mL | 2.8346 mL | |
| 15 mM | 0.0756 mL | 0.3780 mL | 0.7559 mL | 1.8898 mL | |
| 20 mM | 0.0567 mL | 0.2835 mL | 0.5669 mL | 1.4173 mL | |
| 25 mM | 0.0454 mL | 0.2268 mL | 0.4535 mL | 1.1339 mL | |
| 30 mM | 0.0378 mL | 0.1890 mL | 0.3780 mL | 0.9449 mL | |
| 40 mM | 0.0283 mL | 0.1417 mL | 0.2835 mL | 0.7087 mL | |
| 50 mM | 0.0227 mL | 0.1134 mL | 0.2268 mL | 0.5669 mL | |
| 60 mM | 0.0189 mL | 0.0945 mL | 0.1890 mL | 0.4724 mL | |
| 80 mM | 0.0142 mL | 0.0709 mL | 0.1417 mL | 0.3543 mL | |
| 100 mM | 0.0113 mL | 0.0567 mL | 0.1134 mL | 0.2835 mL |
5'-ODMT cEt G Phosphoramidite (Amidite) Related Classifications
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