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Cat. No.: HY-187109

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6-(Cyclobutylamino)-3-pyridinecarboxylic acid

6-(Cyclobutylamino)-3-pyridinecarboxylic acid is a highly selective GPR109b agonist (pEC₅₀ = 7.14) that reverses the Forskolin (HY-15371)-induced elevation of cAMP in stably transfected mammalian cells. 6-(Cyclobutylamino)-3-pyridinecarboxylic acid can be used for the research of dyslipidemia.

For research use only. We do not sell to patients.

CAS No.: 960060-89-3
Formula: C₁₀H₁₂N₂O₂
Molecular Weight:192.22

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Please store the product under the recommended conditions in the Certificate of Analysis.

6-(Cyclobutylamino)-3-pyridinecarboxylic acid Chemical Structure

CAS No.: 960060-89-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

6-(Cyclobutylamino)-3-pyridinecarboxylic acid (compound 6k) acts as a full agonist of GPR109b in stably transfected CHO-K1 cells with a pEC₅₀ of 7.14, and is selective over GPR109a^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 960060-89-3
Molecular Weight 192.22
Formula C₁₀H₁₂N₂O₂
SMILES

O=C(O)C1=CN=C(C=C1)NC2CCC2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Skinner PJ, et al. 3-Nitro-4-amino benzoic acids and 6-amino nicotinic acids are highly selective agonists of GPR109b. Bioorganic & medicinal chemistry letters. 2007 Dec 01;17(23):6619-22. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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6-(Cyclobutylamino)-3-pyridinecarboxylic acid

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6-(Cyclobutylamino)-3-pyridinecarboxylic acid

Biological Activity

Description

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

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6-(Cyclobutylamino)-3-pyridinecarboxylic acid Related Classifications

HY-187109 Related Classifications

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