1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. CNS-5161 hydrochloride

CNS-5161 hydrochloride (Synonyms: CNS 5161A)

Cat. No.: HY-101809
Handling Instructions

CNS-5161 hydrochloride is a novel NMDA ion-channel antagonist that interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.

For research use only. We do not sell to patients.

CNS-5161 hydrochloride Chemical Structure

CNS-5161 hydrochloride Chemical Structure

CAS No. : 160756-38-7

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Description

CNS-5161 hydrochloride is a novel NMDA ion-channel antagonist that interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.

IC50 & Target

NMDA receptor/ion channel[1]

In Vitro

CNS-5161 (CNS 5161) is a novel and selective noncompetitive antagonist of the NMDA subset of glutamate receptors in the mammalian brain. CNS-5161 has potent inhibitory activity in vitro at the NMDA ion channel and is able to displace [3H] MK-801 binding with a Ki of 1.8 nM in synaptosomal membrane preparations from rat brain[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In the neonatal rat NMDA excitotoxicity model in vivo, CNS-5161 (CNS 5161) protects against the necrotic effects of exogenous N-methyl-D-aspartate with an ED80 of 4 mg/kg by the intraperitoneal (i.p.) route. CNS-5161 also shows a 91% inhibition of audiogenic seizures in DBA/2 mice at 4 mg/kg i.p., and has a neuroprotective effect following hypoxix/ischaemic brain injury in neonatal rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

388.38

Formula

C16H19Cl2N3S2

CAS No.
Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
CNS-5161 hydrochloride
Cat. No.:
HY-101809
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