FGFR4-IN-1

Name: FGFR4-IN-1
Brand: MedChemExpress
SKU: HY-100631
Rating: 5.0 (1 reviews)

Cat. No.: HY-100631 Purity: 99.43%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

FGFR4-IN-1 (example 98) is a potent inhibitor of FGFR4 with IC₅₀ of 0.4 nM.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

FGFR4-IN-1 화학구조

CAS No. : 1708971-72-5

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE FGFR4-IN-1

•Heliyon. 2024 May 13.

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Biological Activity
Protocol
순도&문서
References
고객리뷰

제품 설명

FGFR4-IN-1 (example 98) is a potent inhibitor of FGFR4 with IC₅₀ of 0.4 nM.

IC₅₀ & Target^[1]

FGFR4

0.7 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
Hep 3B2	IC₅₀	8.9 nM Compound: 6a	Antiproliferative activity against human Hep3B cells with high FGFR4 expression assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiter-Glo method Antiproliferative activity against human Hep3B cells with high FGFR4 expression assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiter-Glo method	[PMID: 30987781]
Huh-7	IC₅₀	17.3 nM Compound: 6a	Antiproliferative activity against human HuH7 cells with high FGFR4 expression assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiter-Glo method Antiproliferative activity against human HuH7 cells with high FGFR4 expression assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiter-Glo method	[PMID: 30987781]
Huh-7	IC₅₀	25 nM Compound: 69	Antiproliferative activity against human HuH7 cells assessed as reduction in cell viability incubated for 3 days by cell proliferation assay Antiproliferative activity against human HuH7 cells assessed as reduction in cell viability incubated for 3 days by cell proliferation assay	[PMID: 32930584]
SK-HEP1	IC₅₀	>10000 nM Compound: 6a	Antiproliferative activity against human SKHEP1 cells without FGFR4 gene amplification assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiter-Glo method Antiproliferative activity against human SKHEP1 cells without FGFR4 gene amplification assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiter-Glo method	[PMID: 30987781]

In Vitro

FGFR4-IN-1 significantly inhibits the proliferation of HuH-7 hepatocellular carcinoma cells with IC₅₀ of 13 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

493.52

화학식

C₂₄H₂₇N₇O₅

CAS No.

1708971-72-5

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCCC2=C1N=C(C=O)C(CN3C(COCC3)=O)=C2)NC4=NC=C(C#N)C(NCCOC)=C4

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

용액&용해도

In Vitro:

DMSO : 6.4 mg/mL (12.97 mM; Need warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0263 mL	10.1313 mL	20.2626 mL
5 mM	0.4053 mL	2.0263 mL	4.0525 mL
10 mM	0.2026 mL	1.0131 mL	2.0263 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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(per animal)

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.43%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (251 KB) HNMR (291 KB) RP-HPLC (258 KB)

Handling Instructions (2659 KB)

References

[1]. Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors. WO 2015059668A1.

Cell Assay
^[1]

Methylene blue staining proliferation assay (MBS): The effect of compounds on cell proliferation is assessed using HuH-7 hepatocellular carcinoma cells are cultured in the vendor-recommended medium. Specifically, 5000 cells/well are seeded in 96-well tissue culture plates in a total media volume of 100 μL/well and increasing compound dilutions or DMSO are added 24 hours thereafter in triplicates. 72 hours after compound addition, cells are fixed by adding 25 and incubated for 10 minutes at room temperature. Cells are washed three times with H₂O. Cells are washed 3 times with H₂O, 200 mL/well and then lysed by adding 200 mL/well of 3% HCl for 30 minutes at room temperature with shaking. Optical density is measured at A650 nm. The concentration of compound providing 50% of proliferation inhibition with respect to DMSO-treated cells is determined (IC₅₀) using XLFit software.

MCE 는 독립적으로 이러한 방법들의 정확성을 확인하지 않았습니다. 참고용으로만 봐주십시오.

References

[1]. Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors. WO 2015059668A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0263 mL	10.1313 mL	20.2626 mL	50.6565 mL
	5 mM	0.4053 mL	2.0263 mL	4.0525 mL	10.1313 mL
	10 mM	0.2026 mL	1.0131 mL	2.0263 mL	5.0657 mL

FGFR4-IN-1 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGFR4-IN-11708971-72-5FGFRFibroblast growth factor receptorInhibitorinhibitorinhibit

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FGFR4-IN-1

고객리뷰

FGFR4-IN-1 Related Antibodies

1 Publications Citing Use of MCE FGFR4-IN-1

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Protocol

순도&문서

References

고객리뷰

FGFR4-IN-1 Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

FGFR4-IN-1 Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report